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fluocinolone, hydroquinone, and tretinoin topical

Pronunciation: FLOO oh SIN oh lone, HYE droe KWIN one, TRET in oin

Brand: Tri-Luma

What is the most important information I should know about fluocinolone, hydroquinone, and tretinoin topical?

Multum nosun

Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). This medication can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun.

Multum donot

Avoid getting this medication in your mouth, eyes, or nose, and avoid applying it to your lips or in the creases of your nose. If it does get into any of these areas, rinse with water. Do not use the medication on sunburned, windburned, dry, chapped, irritated, or broken skin. Wait until these areas have healed.

Your skin may be more sensitive to weather extremes such as cold and wind. Protect your skin with clothing and use a moisturizing cream or lotion as needed.

Avoid using skin products that can cause irritation, such as harsh soaps, shampoos, or skin cleansers, hair coloring or permanent chemicals, hair removers or waxes, or skin products with alcohol, spices, astringents, or lime. Do not use other medicated skin products unless your doctor has told you to.

What is fluocinolone, hydroquinone, and tretinoin topical?

Fluocinolone is a steroid. It reduces inflammation or swelling.

Hydroquinone topical is a skin bleaching agent.

Tretinoin topical is a form of vitamin A. It helps the skin to renew itself more quickly.

The combination of fluocinolone, hydroquinone, and tretinoin topical is used to treat melasma (dark skin patches) of the face.

Fluocinolone, hydroquinone, and tretinoin topical may also be used for other purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using fluocinolone, hydroquinone, and tretinoin topical?

Before using this medication, tell your doctor if you are allergic to sulfites or if you have asthma.

Multum nopreg

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

The pill form of tretinoin is known to cause birth defects. Although your skin does not absorb as much tretinoin as if you were taking the medication by mouth, it may be best not to use fluocinolone, hydroquinone, and tretinoin topical if you are pregnant. Talk to your doctor first.

Multum nobrfeed

Fluocinolone, hydroquinone, and tretinoin can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use fluocinolone, hydroquinone, and tretinoin topical?

Use this medication exactly as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Fluocinolone, hydroquinone, and tretinoin topical is usually applied nightly, at least 30 minutes before bedtime. Follow your doctor's instructions.

Multum finish

Using use this medication in larger amounts or applying it more often than prescribed will not make it work any faster, and it may increase side effects.

Gently wash your face with a mild cleanser before applying this medication. Rinse and pat dry the skin.

Use only your fingers to apply the medication. Put a pea-sized amount of cream on your fingertip. Apply a thin layer to the discolored skin spots and spread it out to about one-half inch of the skin around the discolored spot. Rub in gently and completely.

Multum donot

Avoid getting this medication in your mouth, eyes, or nose, and avoid applying it to your lips or in the creases of your nose. If it does get into any of these areas, rinse with water. Do not use the medication on sunburned, windburned, dry, chapped, irritated, or broken skin. Wait until these areas have healed.

Multum donot

Do not use fluocinolone, hydroquinone, and tretinoin topical on skin that is sunburned, windburned, dry, chapped, or irritated. Also avoid using this medication in wounds or on areas of eczema. Wait until these conditions have healed before using fluocinolone, hydroquinone, and tretinoin topical.

Do not apply skin moisturizers or cosmetics after applying this medication. Ask your doctor about using skin moisturizers or cosmetics during the day.

Fluocinolone, hydroquinone, and tretinoin topical should be used as part of a complete skin care program that includes avoiding sunlight, using an effective sunscreen (minimum SPF of 30), and wearing protective clothing.

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Store fluocinolone, hydroquinone, and tretinoin topical at room temperature away from moisture and heat.

What happens if I miss a dose?

Use the missed dose as soon as you remember, or wait until the next night to apply the medication. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

An overdose of fluocinolone, hydroquinone, and tretinoin topical applied to the skin is not likely to cause life-threatening symptoms.

What should I avoid while using fluocinolone, hydroquinone, and tretinoin topical?

Multum nosun

Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). This medication can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun.

Your skin may be more sensitive to weather extremes such as cold and wind. Protect your skin with clothing and use a moisturizing cream or lotion as needed.

Avoid using skin products that can cause irritation, such as harsh soaps, shampoos, or skin cleansers, hair coloring or permanent chemicals, hair removers or waxes, or skin products with alcohol, spices, astringents, or lime. Do not use other medicated skin products unless your doctor has told you to.

What are the possible side effects of fluocinolone, hydroquinone, and tretinoin topical?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Multum emt

Stop using this medication and call your doctor if you have any of these serious side effects:

  • darkening of the treated skin;
  • severe skin irritation, blistering, oozing, scaling, or crusting;
  • severe burning or swelling of the skin; or
  • irritation of your eyes, nose, or mouth.

Less serious side effects may include:

  • mild redness, burning, stinging, tingling, itching, swelling, dryness, or peeling of your skin;
  • rash;
  • acne;
  • skin bumps or blisters; or
  • more noticeable red lines or blood vessels showing through your skin.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect fluocinolone, hydroquinone, and tretinoin topical?

Before using this medication, tell your doctor if you also use other medications that can make you more sensitive to sunlight, including:

  • a diuretic (water pill);
  • a tetracycline antibiotic, including minocycline (Dynacin, Minocin, Vectrin), doxycycline (Doryx, Monodox, Vibramycin, Vibra-Tabs), demeclocycline (Declomycin), and others;
  • a fluoroquinolone antibiotic such as ciprofloxacin (Cipro), levofloxacin (Levaquin), and others;
  • a sulfa drug such as Bactrim, Septra, Cotrim, and others;
  • phenothiazines such as chlorpromazine (Thorazine), fluphenazine (Prolixin), mesoridazine (Serentil), perphenazine (Trilafon), prochlorperazine (Compazine), thioridazine (Mellaril), or trifluperazine (Stelazine); or
  • birth control pills or hormone replacement therapy.

This list is not complete and there may be other drugs that can interact with fluocinolone, hydroquinone, and tretinoin. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about fluocinolone, hydroquinone, and tretinoin topical.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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