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linagliptin

Pronunciation: LIN a GLIP tin

Brand: Tradjenta

What is the most important information I should know about linagliptin?

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Do not use this medication if you are allergic to linagliptin or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

Before you take linagliptin, tell your doctor if you have high cholesterol or triglycerides, or a history of pancreatitis.

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Stop taking linagliptin and call your doctor at once if you have severe pain in your upper stomach spreading to your back, nausea and vomiting, loss of appetite, or fast heart rate.

Linagliptin is only part of a complete program of treatment that may also include diet, exercise, weight control, foot care, eye care, dental care, and testing your blood sugar. Follow your diet, medication, and exercise routines very closely. Changing any of these factors can affect your blood sugar levels.

Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office.

What is linagliptin?

Linagliptin is an oral diabetes medicine that helps control blood sugar levels. It works by regulating the levels of insulin your body produces after eating.

Linagliptin is used together with diet and exercise to treat type 2 diabetes. Linagliptin is not for treating type 1 diabetes.

Linagliptin may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking linagliptin?

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Do not use this medication if you are allergic to linagliptin, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

To make sure you can safely take linagliptin, tell your doctor if you have any of these other conditions:

  • high cholesterol or triglycerides (a type of fat in the blood);
  • a history of pancreatitis; or
  • if you are using insulin or taking another oral diabetes medication.

FDA pregnancy category B. Linagliptin is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

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It is not known whether linagliptin passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

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Do not give this medication to anyone under 18 years old without medical advice.

How should I take linagliptin?

Follow the directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Your doctor may occasionally change your dose to make sure you get the best results.

Linagliptin is usually taken once per day. You may take this medicine with or without food. Follow your doctor's instructions.

Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office. Visit your doctor regularly.

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Low blood sugar (hypoglycemia) can happen to everyone who has diabetes. Symptoms include headache, hunger, sweating, pale skin, irritability, dizziness, feeling shaky, or trouble concentrating. Carry hard candy or glucose tablets with you in case you have low blood sugar. Other sugar sources include fruit juice, crackers, raisins, and non-diet soda. Be sure your family and close friends know how to help you in an emergency.

If you have severe hypoglycemia and cannot eat or drink, use an injection of glucagon. Your doctor can give you a prescription for a glucagon emergency injection kit and tell you how to give the injection.

Check your blood sugar carefully during a time of stress or illness, if you travel, exercise more than usual, drink alcohol, or skip meals. These things can affect your glucose levels and your dose needs may also change.

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Your doctor may want you to stop taking linagliptin for a short time if you become ill, have a fever or infection, or if you have surgery or a medical emergency.

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Ask your doctor how to adjust your linagliptin dose if needed. Do not change your medication dose or schedule without your doctor's advice.

Linagliptin is only part of a complete program of treatment that may also include diet, exercise, weight control, foot care, eye care, dental care, and testing your blood sugar. Follow your diet, medication, and exercise routines very closely. Changing any of these factors can affect your blood sugar levels.

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Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

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Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking linagliptin?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of linagliptin?

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Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

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Stop taking linagliptin and call your doctor at once if you have a serious side effect such as:

  • pancreatitis - severe pain in your upper stomach spreading to your back, nausea and vomiting, loss of appetite, fast heart rate; or
  • fever, sore throat, and headache with a severe blistering, peeling, and red skin rash.

Less serious side effects may include:

  • runny or stuffy nose, sore throat;
  • cough;
  • weight gain;
  • muscle or joint pain;
  • headache; or
  • back pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect linagliptin?

Tell your doctor about all medications you use, and those you start or stop using during your treatment with linagliptin, especially:

  • bosentan (Tracleer);
  • dexamethasone (Cortastat, Dexasone, Solurex, DexPak);
  • ketoconazole (Nizoral);
  • quinidine (Quin-G) or verapamil (Calan, Covera, Isoptin, Verelan);
  • rifabutin (Mycobutin), rifampin (Rifadin, Rifater, Rifamate), or rifapentine (Priftin);
  • St. John's wort;
  • phenobarbital (Solfoton) and other barbiturates;
  • medication to treat HIV or AIDS;
  • medicines to treat narcolepsy;
  • medicines used to prevent organ transplant rejection; or
  • seizure medication.

Although linagliptin is not as likely to cause hypoglycemia (low blood sugar) as some other oral diabetes medications, tell your doctor if you are taking any other drugs that can potentially lower blood sugar, such as:

  • probenecid (Benemid);
  • nonsteroidal anti-inflammatory drugs (NSAIDs);
  • aspirin or other salicylates (including Pepto-Bismol);
  • sulfa drugs (Bactrim and others);
  • a monoamine oxidase inhibitor (MAOI);
  • beta-blockers (Tenormin and others); or
  • another oral diabetes medication such as glipizide (Glucotrol, Metaglip), glimepiride (Amaryl, Avandaryl, Duetact), glyburide (DiaBeta, Micronase, Glucovance), and others.

This list is not complete. Other drugs may interact with linagliptin, including prescription, over-the-counter, vitamin, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

Your pharmacist can provide more information about linagliptin.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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