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piperacillin and tazobactam

Pronunciation: pi PER a sil in and tay zoe BAK tam

Brand: Zosyn

What is the most important information I should know about piperacillin and tazobactam?

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You should not use this medication if you are allergic to piperacillin and tazobactam or to any other penicillin antibiotic, such as amoxicillin (Amoxil, Augmentin, Dispermox, Moxatag), ampicillin (Principen, Unasyn), dicloxacillin (Dycill, Dynapen), oxacillin (Bactocill), ticarcillin (Timentin), or penicillin (Bicillin L-A, PC Pen VK, Pfizerpen), and others.

Before using piperacillin and tazobactam tell your doctor if you have kidney disease, a bleeding or blood clotting disorder, low levels of potassium in your blood, cystic fibrosis, a history of allergies, if you are on a low-salt diet, or if you are allergic to a cephalosporin antibiotic such as cefdinir (Omnicef), cefprozil (Cefzil), cefuroxime (Ceftin), cephalexin (Keflex), and others.

Use this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Piperacillin and tazobactam will not treat a viral infection such as the common cold or flu.

Piperacillin and tazobactam may cause bleeding, especially in people with kidney disease or using certain medicines. Tell your doctor if you are using any medication to prevent blood clots such as alteplase (Activase), bivalirudin (Angiomax), clopidogrel (Plavix), dabigatran (Pradaxa), dipyridamole (Persantine, Aggrenox), enoxaparin (Lovenox), fondaparinux (Arixtra), heparin, tenecteplase (TNKase), ticlopidine (Ticlid), tinzaparin (Innohep), warfarin (Coumadin, Jantoven), and others.

What is piperacillin and tazobactam?

Piperacillin is a penicillin antibiotic that fights bacteria in the body.

Tazobactam is an antibiotic similar to a penicillin that fights bacteria in the body.

The combination of piperacillin and tazobactam is used to treat many different infections caused by bacteria, such as urinary tract infections, bone and joint infections, severe vaginal infections, stomach infections, skin infections, and pneumonia.

This medication is sometimes given together with other antibiotics.

Piperacillin and tazobactam may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using piperacillin and tazobactam?

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You should not use this medication if you are allergic to piperacillin and tazobactam or to any other penicillin antibiotic, such as:

  • amoxicillin (Amoxil, Augmentin, Dispermox, Moxatag);
  • ampicillin (Principen, Unasyn);
  • dicloxacillin (Dycill, Dynapen);
  • oxacillin (Bactocill);
  • ticarcillin (Timentin); or
  • penicillin (Bicillin L-A, PC Pen VK, Pfizerpen), and others.

To make sure you can safely use piperacillin and tazobactam, tell your doctor if you have any of these other conditions:

  • kidney disease (or if you are on dialysis);
  • a bleeding or blood clotting disorder;
  • an electrolyte imbalance such as low levels of potassium in your blood;
  • cystic fibrosis;
  • a history of any type of allergy;
  • if you are on a low-salt diet; or
  • if you are allergic to a cephalosporin antibiotic such as cefdinir (Omnicef), cefprozil (Cefzil), cefuroxime (Ceftin), cephalexin (Keflex), and others.

FDA pregnancy category B. Piperacillin and tazobactam is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

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Piperacillin and tazobactam may pass into breast milk and could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use piperacillin and tazobactam?

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Piperacillin and tazobactam is injected into a vein through an IV. You may be shown how to use an IV at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.

Piperacillin and tazobactam must be given slowly, and the IV infusion can take at least 30 minutes to complete.

Piperacillin and tazobactam must be mixed with a liquid (diluent) before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medication.

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Prepare your dose in a syringe, IV bag, or infusion pump only when you are ready to give yourself an injection. Do not use the medication if it has changed colors or has particles in it. Call your doctor for a new prescription.

Piperacillin and tazobactam is usually given for 7 to 10 days, depending on the infection being treated. Follow your doctor's instructions.

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If you use this medication long-term, your blood will need to be tested often. Visit your doctor regularly.

Use a disposable needle only once. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

Use this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Piperacillin and tazobactam will not treat a viral infection such as the common cold or flu.

This medication can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using piperacillin and tazobactam.

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Store unmixed medicine and the liquid diluent at cool room temperature.

Medicine mixed in an IV bag must be used within 24 hours if you keep it at room temperature.

Mixed medicine in an infusion pump must be used within 12 hours if you keep it at room temperature.

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Mixed medication in an IV bag can also be stored in the refrigerator for up to 7 days. Do not freeze. Throw away any unused mixture that has not been used within that time.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

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Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe anxiety, agitation, feeling restless or nervous, or seizure (convulsions).

What should I avoid while using piperacillin and tazobactam?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

What are the possible side effects of piperacillin and tazobactam?

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Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

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Call your doctor at once if you have a serious side effect such as:

  • diarrhea that is watery or bloody;
  • pale or yellowed skin, dark colored urine, fever, confusion or weakness;
  • feeling light-headed or short of breath, rapid heart rate, trouble concentrating;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • dry mouth, increased thirst, confusion, increased urination, muscle pain or weakness, fast heart rate, feeling light-headed, fainting;
  • fever, chills, body aches, flu symptoms;
  • white patches or sores inside your mouth or on your lips; or
  • seizure (convulsions).

Less serious side effects may include:

  • nausea, vomiting, stomach pain or upset;
  • constipation, mild diarrhea;
  • headache, dizziness, agitation;
  • runny nose;
  • anxiety, sleep problems (insomnia);
  • skin rash or itching;
  • pain, swelling, or other irritation where the injection was given; or
  • vaginal itching or discharge.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect piperacillin and tazobactam?

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Piperacillin and tazobactam may cause bleeding, especially in people with kidney disease or using certain medicines. Tell your doctor if you are using any medication to prevent blood clots, such as:

  • abciximab (ReoPro);
  • alteplase (Activase);
  • anagrelide (Agrylin);
  • argatroban (Acova);
  • bivalirudin (Angiomax);
  • cilostazol (Pletal);
  • clopidogrel (Plavix);
  • dipyridamole (Persantine);
  • dabigatran (Pradaxa);
  • dalteparin (Fragmin);
  • dipyridamole (Persantine, Aggrenox);
  • enoxaparin (Lovenox);
  • eptifibatide (Integrelin);
  • fondaparinux (Arixtra);
  • heparin;
  • lepirudin (Refludan);
  • prasugrel (Effient);
  • tenecteplase (TNKase);
  • ticlopidine (Ticlid);
  • tinzaparin (Innohep);
  • tirofiban (Aggrastat);
  • urokinase (Abbokinase); or
  • warfarin (Coumadin, Jantoven).

Tell your doctor about all other medicines you use, especially:

  • probenecid (Benemid); or
  • another antibiotic such as kanamycin (Kantrex), neomycin (Mycifradin, Neo Fradin, Neo Tab), paromomycin (Humatin, Paromycin), streptomycin, tobramycin (Nebcin, Tobi).

This list is not complete and other drugs may interact with piperacillin and tazobactam. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your doctor or pharmacist can provide more information about piperacillin and tazobactam.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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