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paroxetine

Pronunciation: pa ROX a teen

Brand: Paxil, Paxil CR, Pexeva

Paroxetine 10 mg-AND

round, white, imprinted with P1, G

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Paroxetine 10 mg-APO

oblong, white, imprinted with APO, 097

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Paroxetine 10 mg-MYL

oblong, blue, imprinted with N 1, M

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Paroxetine 10 mg-PAR

oval, white, imprinted with par 876

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Paroxetine 10 mg-TEV

round, yellow, imprinted with 7114, 9 3

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Paroxetine 12.5 mg ER-MYL

round, white, imprinted with M P3

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Paroxetine 20 mg-AND

round, white, imprinted with P 2, G

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Paroxetine 20 mg-APO

oblong, white, imprinted with APO, 083

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Paroxetine 20 mg-MYL

oval, blue, imprinted with N 2, M

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Paroxetine 20 mg-PAR

oval, white, imprinted with par 877

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Paroxetine 20 mg-TEV

round, pink, imprinted with 7115, 9 3

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Paroxetine 25 mg ER-MYL

round, lavender, imprinted with M P4

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Paroxetine 30 mg-APO

oblong, white, imprinted with APO, 084

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Paroxetine 30 mg-MYL

round, blue, imprinted with M N3

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Paroxetine 30 mg-PAR

oval, white, imprinted with par 878

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Paroxetine 30 mg-TEV

round, blue, imprinted with 7116, 93

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Paroxetine 40 mg-APO

oval, white, imprinted with 101, APO

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Paroxetine 40 mg-MYL

round, blue, imprinted with M N4

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Paroxetine 40 mg-PAR

oval, white, imprinted with par 879

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Paroxetine 40 mg-TEV

round, green, imprinted with 7121, 93

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Paroxetine ER 12.5 mg-APO

round, yellow, imprinted with GSK, 12.5

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Paroxetine ER 25 mg-APO

round, pink, imprinted with GSK, 25

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Paroxetine ER 37.5 mg-APO

round, blue, imprinted with GSK, 37 5

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Paxil 10 mg

oblong, yellow, imprinted with PAXIL, 10

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Paxil 10 mg-APO

oval, yellow, imprinted with PAXIL, 1 0

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Paxil 20 mg

oval, pink, imprinted with PAXIL, 2 0

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Paxil 30 mg

oblong, blue, imprinted with PAXIL, 30

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Paxil 30 mg-APO

oval, blue, imprinted with PAXIL, 30

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Paxil 40 mg

oblong, green, imprinted with PAXIL, 40

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Paxil 40 mg-APO

oval, green, imprinted with PAXIL, 40

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Paxil CR 12.5 mg

round, yellow, imprinted with PAXIL CR, 12.5

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Paxil CR 12.5 mg-APO

round, yellow, imprinted with GSK, 12.5

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Paxil CR 25 mg

round, pink, imprinted with PAXIL CR, 25

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Paxil CR 25 mg-APO

round, pink, imprinted with GSK, 25

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Paxil CR 37.5 mg

round, blue, imprinted with PAXIL CR, 37.5

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Paxil CR 37.5 mg-APO

round, blue, imprinted with GSK, 37 5

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Pexeva 10 mg

oval, white, imprinted with POT 10

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Pexeva 20 mg

oval, orange, imprinted with POT 20

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Pexeva 30 mg

oval, yellow, imprinted with POT 30

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Pexeva 40 mg

oval, pink, imprinted with POT 40

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What is the most important information I should know about paroxetine?

Multum donot

Do not take paroxetine together with pimozide (Orap), thioridazine (Mellaril), linezolid (Zyvox), methylene blue (Urolene Blue), or a monoamine oxidase inhibitor (MAOI) such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate). A dangerous drug interaction could occur, leading to serious side effects.

Before you take paroxetine, tell your doctor if you have liver or kidney disease, a bleeding or blood clotting disorder, seizures, glaucoma, bipolar disorder, or a history of drug abuse or suicidal thoughts.

Multum emt

There are many other drugs that can interact with paroxetine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products.

Paroxetine may cause harm to an unborn baby. Tell your doctor right away if you become pregnant while taking paroxetine.

Paroxetine may cause heart defects or serious lung problems in a newborn if you take the medication during pregnancy. However, you may have a relapse of depression if you stop taking your antidepressant during pregnancy.

Multum donot

Do not start or stop taking paroxetine during pregnancy without your doctor's advice.

You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

Multum emt

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

What is paroxetine?

Paroxetine is an antidepressant in a group of drugs called selective serotonin reuptake inhibitors (SSRIs). Paroxetine affects chemicals in the brain that may become unbalanced.

Paroxetine is used to treat depression, obsessive-compulsive disorder, anxiety disorders, post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD).

Paroxetine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking paroxetine?

Multum donot

Do not take paroxetine together with pimozide (Orap), thioridazine (Mellaril), linezolid (Zyvox), methylene blue (Urolene Blue), or a monoamine oxidase inhibitor (MAOI) such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate). A dangerous drug interaction could occur, leading to serious side effects.

Multum donot

You must wait at least 14 days after stopping an MAO inhibitor before you can take paroxetine. After you stop taking paroxetine, you must wait at least 14 days before you start taking an MAOI.

Multum emt

Tell your doctor about all other antidepressants you take, especially Celexa, Cymbalta, Desyrel, Effexor, Lexapro, Luvox, Oleptro, Prozac, Sarafem, Symbyax, Viibryd, or Zoloft.

To make sure you can safely take paroxetine, tell your doctor if you have any of these other conditions:

  • liver or kidney disease;
  • a bleeding or blood clotting disorder;
  • seizures or epilepsy;
  • narrrow-angle glaucoma; or
  • bipolar disorder (manic depression), or a history of drug abuse or suicidal thoughts.

You may have thoughts about suicide while taking an antidepressant, especially if you are younger than 24 years old. Tell your doctor if you have worsening depression or suicidal thoughts during the first several weeks of treatment, or whenever your dose is changed.

Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

FDA pregnancy category D. Paroxetine may cause heart defects or serious lung problems in a newborn if you take the medication during pregnancy. However, you may have a relapse of depression if you stop taking your antidepressant during pregnancy. Tell your doctor right away if you become pregnant while taking paroxetine.

Multum donot

Do not start or stop taking paroxetine during pregnancy without your doctor's advice.

Multum nobrfeed

Paroxetine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take paroxetine?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results.

Multum nocrush

Do not crush, chew, or break an extended-release tablet. Swallow it whole. Breaking or opening the pill may cause too much of the drug to be released at one time.

Multum shake

Shake the oral suspension (liquid) well just before you measure a dose. Measure the liquid with a special dose measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose measuring device, ask your pharmacist for one.

Multum finish

It may take up to 4 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve after 4 weeks of treatment.

You may have withdrawal symptoms (such as agitation, dizziness, numbness or tingling, ringing in your ears, confusion, or behavior changes) after you stop taking paroxetine. Do not stop taking this medication suddenly without first talking to your doctor.

Multum rt

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of paroxetine can be fatal. Overdose symptoms may include extreme drowsiness, vomiting, tremor, confusion, decreased urination, blurred vision, rapid heartbeat, aggression, seizures, and coma.

What should I avoid while taking paroxetine?

Multum noalcohol

Drinking alcohol can increase some of the side effects of paroxetine.

Multum dizzy

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

What are the possible side effects of paroxetine?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: skin rash or hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Multum donot

Call your doctor at once if you have a serious side effect such as:

  • unusual bone pain or tenderness, swelling or bruising;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), coughing up blood;
  • agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, feeling unsteady, loss of coordination, fainting;
  • very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, overactive reflexes, feeling like you might pass out;
  • headache, trouble concentrating, memory problems, weakness, confusion, hallucinations, fainting, seizure, shallow breathing or breathing that stops; or
  • severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Less serious side effects may include:

  • mild headache, drowsiness, dizziness, sleep problems (insomnia), feeling restless or nervous;
  • mild nausea, constipation, weight changes;
  • decreased sex drive, impotence, or difficulty having an orgasm; or
  • dry mouth, yawning, or ringing in your ears.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect paroxetine?

Multum dizzy

Cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures or anxiety can add to sleepiness caused by paroxetine. Tell your doctor if you regularly use any of these medicines, or any other antidepressant.

Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) for pain, arthritis, fever, or swelling. This includes aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Cataflam, Voltaren), indomethacin (Indocin), meloxicam (Mobic), and others. Taking an NSAID with paroxetine may cause you to bruise or bleed easily.

Many drugs can interact with paroxetine. Below is just a partial list. Tell your doctor if you are using:

  • a blood thinner such as warfarin (Coumadin, Jantoven);
  • cimetidine (Tagamet);
  • fentanyl (Abstral, Actiq, Duragesic, Fentora, Onsolis);
  • fosamprenavir (Lexiva) or ritonavir (Norvir, Kaletra);
  • St. John's wort;
  • tamoxifen (Nolvadex, Soltamox);
  • theophylline (Elixophyllin, Theo-24, Theochron, Uniphyl);
  • tramadol (Ultram, Ultracet);
  • tryptophan (also called L-tryptophan);
  • heart medication such as digoxin (digitalis, Lanoxin), quinidine (Quin-G), procainamide (Pronestyl), disopyramide (Norpace), flecaininde (Tambocor), mexiletine (Mexitil), propafenone, (Rythmol), and others;
  • any other antidepressant such as amitriptyline (Elavil, Vanatrip, Limbitrol), citalopram (Celexa), desipramine (Norpramin), doxepin (Sinequan), fluoxetine (Prozac, Sarafem, Symbyax), nortriptyline (Pamelor), sertraline (Zoloft), and others;
  • medicine to treat psychiatric disorders, such as chlorpromazine (Thorazine), fluphenazine (Permitil, Prolixin), haloperidol (Haldol), lithium (Lithobid, Eskalith), perphenazine (Trilafon), or risperidone (Risperdal); or
  • almotriptan (Axert), frovatriptan (Frova), sumatriptan (Imitrex, Treximet), naratriptan (Amerge), rizatriptan (Maxalt), or zolmitriptan (Zomig).

This list is not complete and other drugs may interact with paroxetine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about paroxetine.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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