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posaconazole

Pronunciation: poe sa KONE a zole

Brand: Noxafil

What is the most important information I should know about posaconazole?

Multum donot

You should not use this medication if you are allergic to posaconazole or similar antifungals such as clotrimazole (Mycelex Troche), fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), miconazole (Oravig, Monistat), voriconazole (Vfend), and others.

Multum donot

You should not take posaconazole together with cimetidine (Tagamet), phenytoin (Dilantin), pimozide (Orap), quinidine (Quin-G), rifabutin (Mycobutin), sirolimus (Rapamune), atorvastatin (Lipitor, Caduet), lovastatin (Mevacor, Altoprev, Advicor), simvastatin (Zocor, Simcor, Vytorin, Juvisync), or an ergot medicine such as ergotamine (Ergomar), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), or methylergonovine (Methergine).

Multum finish

Take this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Posaconazole will not treat a viral infection such as the common cold or flu.

Multum emt

Call your doctor if you have ongoing vomiting or diarrhea. Posaconazole may not work as well while during this time.

What is posaconazole?

Posaconazole is an antifungal medication that fights certain infections caused by fungus.

Posaconazole is used to prevent fungal infections in people with weak immune systems resulting from certain treatments or conditions (such as chemotherapy, stem cell transplantation, HIV infection, and others).

Posaconazole is also used to treat oral thrush (yeast infection of the mouth).

Posaconazole may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using posaconazole?

Multum donot

You should not use this medication if you are allergic to posaconazole or similar antifungals such as clotrimazole (Mycelex Troche), fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), miconazole (Oravig, Monistat), voriconazole (Vfend), and others.

Many drugs can interact with posaconazole and some should not be used at the same time. Tell your doctor about all other medications you use, especially:

  • cimetidine (Tagamet);
  • phenytoin (Dilantin);
  • pimozide (Orap);
  • quinidine (Quin-G);
  • rifabutin (Mycobutin);
  • sirolimus (Rapamune);
  • cholesterol lowering medicines such as atorvastatin (Lipitor, Caduet), lovastatin (Mevacor, Altoprev, Advicor), or simvastatin (Zocor, Simcor, Vytorin, Juvisync); or
  • ergot medicine such as ergotamine (Ergomar), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), or methylergonovine (Methergine).

To make sure you can safely take posaconazole, tell your doctor if you have any of these other conditions:

  • a personal or family history of Long QT syndrome;
  • liver disease; or
  • a heart rhythm disorder.
Multum nopreg

FDA pregnancy category C. It is not known whether posaconazole will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

Multum nobrfeed

It is not known whether posaconazole passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using posaconazole.

Multum nochild

Do not give this medication to a child younger than 13 years old.

How should I take posaconazole?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Multum food

Posaconazole works best if you take it within 20 minutes after a full meal or a nutritional supplement (such as Ensure).

Multum shake

Shake the oral suspension (liquid) well just before you measure a dose. Measure the liquid with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Multum emt

Call your doctor if you have ongoing vomiting or diarrhea. Posaconazole may not work as well while during this time.

To be sure this medication is not causing harmful effects, your blood may need to be tested often. Your liver function may also need to be tested. Visit your doctor regularly.

Multum finish

Take this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Posaconazole will not treat a viral infection such as the common cold or flu.

Multum rt

Store at room temperature away from moisture and heat. Do not freeze. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking posaconazole?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of posaconazole?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Multum donot

Call your doctor at once if you have a serious side effect such as:

  • headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;
  • slow heartbeats;
  • signs of an infection such as fever, chills, sore throat, flu symptoms, vomiting, mouth sores;
  • pale skin, easy bruising or bleeding, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;
  • low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling);
  • feeling like you might pass out;
  • nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or
  • dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, chest pain, shortness of breath, seizure).

Less serious side effects may include:

  • mild headache, dizziness;
  • tired feeling
  • swelling of your ankles or feet;
  • diarrhea, constipation, stomach pain;
  • joint or muscle pain; or
  • sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect posaconazole?

Many drugs can interact with posaconazole. Below is just a partial list. Tell your doctor if you are using:

  • cyclosporine (Neoral, Sandimmune, Gengraf);
  • digoxin (digitalis, Lanoxin);
  • esomeprazole (Nexium);
  • glipizide (Glucotrol, Metaglip);
  • metoclopramide (Reglan, Metozolv);
  • tacrolimus (Prograf);
  • an antibiotic such as azithromycin (Zithromax, Zmax, Z-Pack), clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), levofloxacin (Levaquin), moxifloxacin (Avelox), or pentamidine (NebuPent, Pentam);
  • an antidepressant;
  • cancer medicines such as vinblastine (Velban), vincristine (Oncovin, Vincasar), vindesine (Eldisine), or vinorelbine (Navelbine);
  • cholesterol lowering medication such as fluvastatin (Lescol), pitavastatin (Livalo), pravastatin (Pravachol), or rosuvastatin (Crestor);
  • heart or blood pressure medicine such as amlodipine (Norvasc, Caduet, Exforge, Lotrel, Tekamlo, Tribenzor, Twynsta, Amturnide), diltiazem (Cardizem, Cartia, Dilacor, Diltia, Diltzac, Taztia, Tiazac), felodipine (Plendil), nicardipine (Cardene), nifedipine (Nifedical, Procardia), verapamil (Calan, Covera, Isoptin, Verelan, Tarka), and others;
  • heart rhythm medication such as amiodarone (Cordarone, Pacerone) or disopyramide (Norpace);
  • HIV or AIDS medications such as atazanavir (Reyataz), efavirenz (Sustiva, Atripla), fosamprenavir (Lexiva), or ritonavir (Norvir, Kaletra);
  • medicines to treat psychiatric disorders;
  • migraine headache medicine such as sumatriptan (Imitrex) or zolmitriptan (Zomig);
  • narcotic medication; or
  • a sedative such as alprazolam (Xanax), midazolam (Versed), or triazolam (Halcion).
Multum donot

This list is not complete and there are many other drugs that can interact with posaconazole. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

Where can I get more information?

Your pharmacist can provide more information about posaconazole.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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