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naloxone and pentazocine (oral)

Pronunciation: nal OX one and pen TAZ oh seen

Brand: Talwin NX

Naloxone-Pentazocine 50 mg-WAT

oblong, green, imprinted with 395 50 0 .5, WATSON

Image of Naloxone-Pentazocine 50 mg-WAT
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What is the most important information I should know about naloxone and pentazocine?

Multum donot

You should not use this medication if you are allergic to naloxone (Narcan, Suboxone) or pentazocine (Talacen).

Never crush a naloxone and pentazocine tablet to mix into a liquid for injecting the drug into your vein. This practice has resulted in death with the misuse of pentazocine and similar prescription drugs.

Multum habit

Naloxone and pentazocine may be habit-forming and should be used only by the person for whom it was prescribed. Keep this medication in a secure place where others cannot get to it.

Multum donot

Never take naloxone and pentazocine in larger amounts, or for longer than recommended by your doctor. Tell your doctor if the medicine seems to stop working as well in relieving your pain.

Multum noalcohol

Do not drink alcohol while you are using this medication. Dangerous side effects or death can occur when alcohol is combined with naloxone and pentazocine. Check your food and medicine labels to be sure these products do not contain alcohol.

Multum dizzy

This medication may impair your thinking or reactions. Avoid driving or operating machinery until you know how naloxone and pentazocine will affect you.

Multum donot

Do not stop using naloxone and pentazocine suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using naloxone and pentazocine.

What is naloxone and pentazocine?

Naloxone is an special narcotic drug that reverses the effects of other narcotic medicines.

Pentazocine is an opioid pain medication. An opioid is sometimes called a narcotic.

The combination of naloxone and pentazocine is used to treat moderate-to-severe pain. Naloxone is included in this medication to prevent the misuse of the narcotic ingredient.

Naloxone and pentazocine may also be used for purposes not listed in this medication guide.

What should I discuss with my health care provider before taking naloxone and pentazocine?

Multum donot

You should not use this medication if you are allergic to naloxone (Narcan, Suboxone) or pentazocine (Talacen).

To make sure you can safely take naloxone and pentazocine, tell your doctor if you have any of these other conditions:

  • asthma, COPD, sleep apnea, or other breathing disorders;
  • liver or kidney disease;
  • heart disease or history of heart attack;
  • underactive thyroid;
  • a blockage in your digestive tract (stomach or intestines);
  • a history of head injury or brain tumor;
  • epilepsy or other seizure disorder;
  • Addison's disease or other adrenal gland disorder;
  • low blood pressure;
  • gallbladder or pancreas problems:
  • porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system);
  • enlarged prostate, urination problems;
  • mental illness;
  • a history of drug or alcohol addiction; or
  • if you have recently received other narcotic pain medicine or methadone.
Multum habit

Naloxone and pentazocine may be habit forming and should be used only by the person for whom it was prescribed. Never share naloxone and pentazocine with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.

Multum nopreg

FDA pregnancy category C. It is not known whether naloxone and pentazocine will harm an unborn baby. Naloxone and pentazocine may cause addiction or withdrawal symptoms in a newborn if the mother takes the medication during pregnancy. Tell your doctor if you are pregnant or plan to become pregnant while using naloxone and pentazocine.

Multum nobrfeed

Naloxone and pentazocine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Multum nochild

Naloxone and pentazocine should not be given to a child younger than 12 years old.

How should I take naloxone and pentazocine?

Multum emt

Take exactly as prescribed. Never take naloxone and pentazocine in larger amounts, or for longer than recommended by your doctor. Follow the directions on your prescription label. Tell your doctor if the medicine seems to stop working as well in relieving your pain.

Naloxone and pentazocine is usually taken as 1 or 2 tablets every 3 to 4 hours. Follow your doctor's instructions. Do not take more than 12 tablets in a 24-hour period.

Never crush a naloxone and pentazocine tablet to mix into a liquid for injecting the drug into your vein. This practice has resulted in death with the misuse of pentazocine and similar prescription drugs.

Multum donot

Do not stop using naloxone and pentazocine suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication.

Multum rt

Store at room temperature away from moisture and heat.

Keep track of the amount of medicine used from each new bottle. Naloxone and pentazocine is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

What happens if I miss a dose?

Since naloxone and pentazocine is taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Multum emt

Do not take more than 12 tablets in a 24-hour period.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include extreme drowsiness, cold and clammy skin, pinpoint pupils, shallow breathing, slow heart rate, fainting, seizure (convulsions), or coma.

What should I avoid while taking naloxone and pentazocine?

Multum noalcohol

Do not drink alcohol while you are taking naloxone and pentazocine. Alcohol can increase some of the side effects of narcotic pain medicine.

Multum dizzy

Naloxone and pentazocine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Multum smoking

Avoid smoking, which can make this medication less effective in relieving your pain.

What are the possible side effects of naloxone and pentazocine?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Multum donot

Stop using this medication and call your doctor at once if you have a serious side effect such as:

  • weak or shallow breathing, slow heartbeats;
  • confusion, hallucinations, unusual thoughts or behavior;
  • severe weakness or dizziness;
  • seizure (convulsions);
  • feeling like you might pass out; or
  • severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Less serious side effects may include:

  • dizziness, drowsiness;
  • headache, weakness;
  • feeling restless or irritable;
  • diarrhea, constipation;
  • dry mouth, nausea, vomiting, loss of appetite;
  • tremor, chills, sweating;
  • flushing (warmth, redness, or tingly feeling);
  • sleep problems (insomnia), strange dreams;
  • blurred vision; or
  • ringing in your ears.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect naloxone and pentazocine?

Multum dizzy

You should not take naloxone and pentazocine with any other narcotic pain medications, sedatives, tranquilizers, sleeping pills, muscle relaxers, or other medicines that can make you sleepy or slow your breathing. Dangerous side effects may result. Tell your doctor if you regularly use any of these medications, or medicine for seizures, depression, or anxiety.

Multum donot

If you are using any other opioid pain medication, the pain-relieving effects of the narcotic will be reversed while you are also receiving naloxone and pentazocine. Opioid medicines include:

  • codeine (Tylenol #3);
  • fentanyl (Abstral, Actiq, Fentora, Duragesic, Lazanda, Onsolis);
  • hydrocodone (Lortab, Vicodin, Vicoprofen);
  • hydromorphone (Dilaudid, Palladone);
  • methadone (Methadose, Dolophine);
  • morphine (Kadian, MS Contin, Oramorph);
  • oxycodone (OxyContin, Combunox, Roxicodone, Percocet); or
  • and many others.

Tell your doctor about all other medicines you use, especially:

  • an antidepressant such as amitriptyline (Elavil, Vanatrip, Limbitrol), doxepin (Sinequan, Silenor), nortriptyline (Pamelor), and others;
  • an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate); or
  • a phenothiazine such as chlorpromazine (Thorazine), fluphenazine (Permitil, Prolixin), perphenazine (Trilafon), prochlorperazine (Compazine, Compro), promethazine (Pentazine, Phenergan, Anergan, Antinaus), thioridazine (Mellaril), or trifluoperazine (Stelazine).

This list is not complete and other drugs may interact with naloxone and pentazocine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about naloxone and pentazocine.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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