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mirabegron

Pronunciation: MIR a BEG ron

Brand: Myrbetriq

What is the most important information I should know about mirabegron?

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You should not use mirabegron if you are allergic to it, or if you have severe kidney disease, severe liver disease, or untreated or uncontrolled hypertension (high blood pressure).

Before you take mirabegron, tell your doctor if you have kidney or liver disease, high blood pressure, glaucoma, an enlarged prostate or trouble urinating, or a blockage in your digestive tract (stomach or intestines).

Your blood pressure will need to be checked often. Visit your doctor regularly.

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It may take up to 8 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve after 8 weeks of treatment.

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Serious side effects may include fast or pounding heartbeats, pain or burning when you urinate, or increased blood pressure (severe headache, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

Tell your doctor about all other medicines you use, especially blood pressure medication, an antidepressant or medicine to treat a psychiatric disorder, cancer medicine, cough medicine, heart rhythm medication, prescription pain medicine, or other drugs to treat overactive bladder.

What is mirabegron?

Mirabegron reduces muscle spasms of the bladder and urinary tract.

Mirabegron is used to treat overactive bladder with symptoms of frequent or urgent urination and urinary incontinence.

Mirabegron may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking mirabegron?

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You should not use mirabegron if you are allergic to it, or if you have severe kidney disease, severe liver disease, or untreated or uncontrolled hypertension (high blood pressure).

To make sure you can safely use mirabegron, tell your doctor if you have any of these other conditions:

  • kidney disease;
  • liver disease;
  • high blood pressure;
  • glaucoma;
  • enlarged prostate or trouble urinating; or
  • a blockage in your digestive tract (stomach or intestines).
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FDA pregnancy category C. It is not known whether mirabegron will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

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Mirabegron can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using mirabegron.

How should I take mirabegron?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

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Take this medicine with a full glass of water.

Mirabegron is usually taken once per day. Follow your doctor's instructions.

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Do not crush, chew, or break an extended-release tablet. Swallow it whole. Breaking the pill may cause too much of the drug to be released at one time.

Your blood pressure will need to be checked often. Visit your doctor regularly.

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It may take up to 8 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve after 8 weeks of treatment.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

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Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include rapid pulse, and pounding heartbeats or fluttering in your chest.

What should I avoid while taking mirabegron?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of mirabegron?

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Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

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Stop using mirabegron and call your doctor at once if you have a serious side effect such as:

  • fast or pounding heartbeats;
  • pain or burning when you urinate;
  • painful or difficult urinatinn, trouble emptying your bladder; or
  • dangerously high blood pressure (severe headache, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure);

Less serious side effects may include:

  • headache, joint pain;
  • dizziness, blurred vision;
  • tired feeling;
  • dry mouth, stomach pain, nausea;
  • diarrhea, constipation, bloating; or
  • sinus pain, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect mirabegron?

Tell your doctor about all other medicines you use, especially:

  • digoxin (Lanoxin, Lanoxicaps);
  • an antidepressant (Elavil, Vanatrip, Norpramin, Sinequan, Cymbalta, Prozac, Tofranil, Paxil, Zoloft, Effexor, and others);
  • blood pressure medication (Captopril, Coreg, Normodyne, Lopressor, Toprol, Inderal, and others);
  • cancer medicine such as doxorubicin (Adriamycin, Doxil), lomustine (CeeNU), tamoxifen (Soltamox);
  • cough medicine that contains dextromethorphan (a cough suppressant);
  • drugs to treat enlarged prostate with urinary problems, such as tamsulosin (Flomax, Jalyn);
  • a heart rhythm medication such as flecainide (Tambocor), procainamide (Procan, Pronestyl), or propafenone (Rythmol);
  • medicine to treat psychiatric disorders (Haldol, Thorazine, Permitil, Risperdal, Mellaril, and others);
  • other drugs to treat overactive bladder, such as hyoscyamine (Anaspaz, Cystospaz, Hyospaz, Levbid, Symax, and others), oxybutynin (Ditropan, Urotrol, Oxytrol, Anturol, Gelnique), solifenacin (VESIcare), or tolterodine (Detrol); or
  • prescription pain medicine (Vicodin, OxyContin, Percocet, Ultram, Ultracet, and others).

There may be other drugs that can interact with mirabegron. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about mirabegron.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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