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hydrochlorothiazide and propranolol

Pronunciation: HYE droe klor oh THYE a zide and proe PRAN oh lol

Brand: Inderide

HCTZ-Propranolol 40 mg-25 mg-MYL

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HCTZ-Propranolol 80 mg-25 mg-MYL

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What is the most important information I should know about hydrochlorothiazide and propranolol?

Multum donot

You should not use this medication if you have asthma, severe or uncontrolled heart failure, a heart condition called "sick sinus syndrome" or "AV block," or if you are unable to urinate.

Before using this medication, tell your doctor if you have congestive heart failure, kidney or liver disease, cirrhosis, glaucoma, bronchospastic lung disease, gout, lupus, diabetes, a thyroid disorder, or if you are allergic to sulfa drugs or penicillin.

If you are diabetic, check your blood sugar carefully. Using propranolol can make it harder for you to tell when you have low blood sugar. Your insulin or diabetic medication needs may change while you are taking hydrochlorothiazide and propranolol. Talk with your doctor before changing any doses.

Multum noalcohol

Drinking alcohol can further lower your blood pressure and may increase your blood levels of propranolol.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

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Keep using this medication even if you feel fine. High blood pressure often has no symptoms.

There are many other medicines that can interact with hydrochlorothiazide and propranolol. Tell your doctor about all the prescription and over-the-counter medications you use.

What is hydrochlorothiazide and propranolol?

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Propranolol is a beta-blocker. Beta-blockers affect the heart and circulation (blood flow through arteries and veins).

The combination of hydrochlorothiazide and propranolol is used to treat high blood pressure (hypertension).

Hydrochlorothiazide and propranolol may also be used for purposes not listed in this medication guide.

What should I discuss with my doctor before taking hydrochlorothiazide and propranolol?

Multum donot

You should not use this medication if you are allergic to hydrochlorothiazide or propranolol, or if you have:

  • asthma;
  • severe or uncontrolled heart failure;
  • a heart condition called "sick sinus syndrome" or "AV block" (2nd or 3rd degree); or
  • if you are unable to urinate.

To make sure you can safely take hydrochlorothiazide and propranolol, tell your doctor if you have any of these other conditions:

  • congestive heart failure;
  • kidney disease;
  • liver disease (or cirrhosis);
  • glaucoma;
  • bronchospastic lung disease;
  • a thyroid disorder;
  • lupus;
  • gout;
  • diabetes; or
  • if you are allergic to sulfa drugs or penicillin.
Multum nopreg

FDA pregnancy category C. It is not known whether hydrochlorothiazide and propranolol will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

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Hydrochlorothiazide and propranolol can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take hydrochlorothiazide and propranolol?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results.

Multum donot

Do not stop using hydrochlorothiazide and propranolol suddenly, or you could have a serious or life-threatening heart problem. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication.

Your blood pressure will need to be checked often. Your blood and urine may both be tested if you have been vomiting or are dehydrated. Visit your doctor regularly.

If you are diabetic, check your blood sugar carefully. Using propranolol can make it harder for you to tell when you have low blood sugar. Your insulin or diabetic medication needs may change while you are taking hydrochlorothiazide and propranolol. Talk with your doctor before changing any doses.

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If you need surgery or medical tests, tell the doctor ahead of time that you are taking medication that contains hydrochlorothiazide. You may need to stop using the medicine for a short time.

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Keep using hydrochlorothiazide and propranolol even if you feel fine. High blood pressure often has no symptoms.

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Store this medication in a tightly closed container at room temperature, away from heat and moisture.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

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Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include slow heart rate, feeling like you might pass out, trouble breathing, or increased urination.

What should I avoid while taking hydrochlorothiazide and propranolol?

Avoid using antacids without your doctor's advice. Use only the specific type of antacid your doctor recommends. Antacids contain different medicines and some types can make it harder for your body to absorb hydrochlorothiazide and propranolol.

Multum noalcohol

Drinking alcohol can further lower your blood pressure and may increase your blood levels of propranolol.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

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Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

What are the possible side effects of hydrochlorothiazide and propranolol?

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Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

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Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • eye pain, vision problems;
  • swelling, rapid weight gain, feeling short of breath, even with mild exertion;
  • fast, slow, or uneven heartbeat;
  • easy bruising or bleeding;
  • numbness or tingly feeling in your hands or feet;
  • feeling weak, drowsy, restless, or light-headed;
  • nausea, vomiting, dry mouth, extreme thirst, headache, confusion, hallucinations, seizure (convulsions);
  • increased urination, leg discomfort, muscle pain or weakness or limp feeling;
  • urinating less than usual or not at all;
  • fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or
  • upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

  • diarrhea, constipation, upset stomach;
  • dizziness, spinning sensation;
  • sore throat, body aches;
  • blurred vision;
  • depressed mood; or
  • sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect hydrochlorothiazide and propranolol?

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Tell your doctor if you regularly use other medicines that make you light-headed (especially narcotic pain medication or barbiturates). They can add to the side effects of hydrochlorothiazide and propranolol.

Many drugs can interact with hydrochlorothiazide and propranolol. Below is just a partial list. Tell your doctor if you are using:

  • chlorpromazine (Thorazine);
  • cimetidine (Tagamet);
  • haloperidol (Haldol);
  • insulin or oral diabetes medication;
  • phenytoin (Dilantin);
  • rifampin (Rifadin, Rifamate, Rimactane);
  • theophylline (Elixophyllin, Respbid, Slo-Bid, Theo-Dur, Uniphyl, and others);
  • steroids (prednisone and others);
  • other blood pressure medications, (especially reserpine);
  • a calcium channel blocker such as amlodipine (Norvasc, Caduet, Exforge, Lotrel, Tekamlo, Tribenzor, Twynsta, Amturnide), diltiazem (Cartia, Cardizem), nifedipine (Nifedical, Procardia), verapamil (Calan, Covera, Isoptin, Verelan), and others; or
  • NSAIDs (non-steroidal anti-inflammatory drugs) such as aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others.

This list is not complete and other drugs may interact with hydrochlorothiazide and propranolol. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about hydrochlorothiazide and propranolol.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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