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American Family Children's Hospital


Pronunciation: tel A pre vir

Brand: Incivek

What is the most important information I should know about telaprevir?

Multum donot

Telaprevir must be used in combination with peginterferon alfa and ribavirin.

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Do not use this combination of drugs if you are pregnant, or if you are a man and your sexual partner is pregnant.

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Telaprevir with peginterferon alfa and ribavirin may cause a life-threatening skin reaction. Stop taking these medicines and call your doctor right away if you have a skin rash with other symptoms such as: fever, swelling in your face, redness in your eyes, mouth ulcers, skin sores, or blistering and peeling.

Certain other drugs may interact with telaprevir or should not be used at the same time. Tell each of your healthcare providers about all medicines you use now, and any medicine you start or stop using.

What is telaprevir?

Telaprevir is an antiviral medicine that prevents certain virus cells from multiplying in your body.

Telaprevir is used in combination with peginterferon alfa and ribavirin to treat hepatitis C in adults.

Telaprevir may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking telaprevir?

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You should not use telaprevir if you are allergic to it.

Do not take telaprevir as your only hepatitis medicine. Telaprevir must be used in combination with peginterferon alfa and ribavirin. Read the medication guide or patient instructions provided with each medicine you take. In some cases, you may not be able to use this drug combination.

To make sure telaprevir is safe for you, tell your doctor if you have:

  • liver problems other than hepatitis C (including hepatitis B);
  • kidney disease (or if you are on dialysis);
  • anemia (lack of red blood cells);
  • HIV or AIDS;
  • a history of gout;
  • if you have had an organ transplant; or
  • if you have ever used medicine to treat hepatitis in the past and it did not work.
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Some medicines can cause unwanted or dangerous effects when used with telaprevir. Your doctor may need to change your treatment plan if you use any of the following drugs:

  • alfuzosin;
  • cisapride;
  • pimozide;
  • rifampin;
  • St. John's wort;
  • lovastatin, simvastatin;
  • oral midazolam or triazolam;
  • ergonovine, ergotamine, dihydroergotamine, methylergonovine;
  • the seizure medications carbamazepine, phenobarbital, or phenytoin; or
  • sildenafil (Revatio) or tadalafil (Adcirca) when used to treat pulmonary arterial hypertension.
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FDA pregnancy category X. Telaprevir is given together with peginterferon alfa and ribavirin. Although telaprevir is not expected to harm an unborn baby, ribavirin is known to cause birth defects or death in an unborn baby. Do not use this combination of drugs if you are pregnant, or if you are a man and your sexual partner is pregnant. If you are a woman, you may need to have a negative pregnancy test before using these medications and every month during your treatment.

  • Use at least 2 non-hormonal forms of birth control while either sexual partner is using telaprevir with peginterferon alfa and ribavirin. Keep using 2 forms of birth control for at least 6 months after treatment ends.
  • If you are a woman, do not use telaprevir with peginterferon alfa and ribavirin if you are pregnant.
  • If you are a man, do not use telaprevir with peginterferon alfa and ribavirin if your sexual partner is pregnant. An unborn baby could also be harmed if a man fathers the child while he is taking ribavirin.
  • Hormonal contraception (such as birth control pills, injections, implants, skin patches, and vaginal rings) may not be effective enough to prevent pregnancy during your treatment. Ask your doctor about using a non-hormone method of birth control (such as a condom, intrauterine device (IUD), diaphragm with spermicide) to prevent pregnancy while taking telaprevir.
  • Tell your doctor right away if a pregnancy occurs while either the mother or the father is using telaprevir with peginterferon alfa and ribavirin.
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It is not known whether telaprevir passes into breast milk or if it could harm a nursing baby. Do not breast-feed a baby while taking telaprevir.

How should I take telaprevir?

Telaprevir is used in combination with peginterferon alfa and ribavirin. Follow all directions on your prescription label. Your doctor may occasionally change your doses to make sure you get the best results. Do not take these medicines in larger or smaller amounts or for longer than recommended.

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Do not change your doses or medication schedule without your doctor's advice. Every person with hepatitis C should remain under the care of a doctor.

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Eat a meal or snack that contains about 20 grams of fat within 30 minutes before you take telaprevir. Always take telaprevir with food. Examples of snacks that contain about 20 grams of fat include: A bagel and cream cheese, 3 tablespoons of peanut butter, 2 ounces of American or cheddar cheese, 2 ounces of potato chips, a half-cup of nuts or trail mix, or 1 cup of ice cream.

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Do not crush, chew, or break a telaprevir tablet. Swallow it whole.

Your total daily dose of 6 tablets is contained in a single blister strip of telaprevir. A package of telaprevir contains 4 cartons of 7 blister strips for a 4-week supply.

To be sure this medicine is helping your condition, you will need frequent blood tests. Treatment with telaprevir may be discontinued based on the results of these tests.

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Drink plenty of liquids while you are taking this medicine.

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Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking this medicine.

If you need surgery, tell the surgeon ahead of time that you are using telaprevir. You may need to stop using the medicine for a short time.

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Do not stop taking this medicine unless your doctor tells you to. If you stop taking telaprevir for any reason, do not start taking it again without your doctor's advice.

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Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If you are more than 6 hours late, skip the missed dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

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Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking telaprevir?

Taking this medicine will not prevent you from passing hepatitis C to other people. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

What are the possible side effects of telaprevir?

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Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

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Telaprevir with peginterferon alfa and ribavirin may cause a life-threatening skin reaction. Stop taking these medicines and call your doctor right away if you have a skin rash with other symptoms such as: fever, swelling in your face, redness in your eyes, mouth ulcers, skin sores, or blistering and peeling.

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Call your doctor at once if you have:

  • pale skin, feeling light-headed or short of breath;
  • fever, swollen glands, body aches, flu symptoms;
  • easy bruising or bleeding, severe tingling, numbness, pain, muscle weakness;
  • upper stomach pain, loss of appetite, dark urine, jaundice (yellowing of the skin or eyes);
  • chest pain, irregular heart rhythm, feeling short of breath;
  • heavy sweating, feeling very thirsty or hot, being unable to urinate, or hot and dry skin;
  • confusion, nausea and vomiting, swelling, rapid weight gain, little or no urinating; or
  • new or worsening cough with fever, trouble breathing.

Common side effects may include:

  • tired feeling;
  • nausea, vomiting, diarrhea, altered sense of taste;
  • rectal itching, burning, or discomfort; or
  • mild non-progressive skin rash or itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect telaprevir?

Many drugs can interact with telaprevir. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment with telaprevir, especially:

  • bosentan, colchicine, escitalopram, fentanyl, methadone, repaglinide, zolpidem (Ambien), warfarin (Coumadin);
  • birth control pills or hormone replacement therapy;
  • sildenafil (Viagra) and other erectile dysfunction medicines;
  • an antibiotic or antifungal medicine --clarithromycin, erythromycin, itraconazole, ketoconazole, posaconazole, rifabutin, telithromycin, voriconazole; a sedative --alprazolam, trazodone; asthma or allergy medicine --budesonide, fluticasone, salmeterol (Advair, Serevent);
  • cholesterol-lowering drugs --atorvastatin, fluvastatin, pitavastatin, pravastatin, rosuvastatin; HIV or AIDS medicines --efavirenz, tenofovir, or ritonavir in combination with atazanavir, darunavir, fosamprenavir, or lopinavir;
  • heart or blood pressure medicine --amlodipine, amiodarone, digoxin, diltiazem, felodipine, flecainide, nicardipine, nifedipine, nisoldipine, propafenone, quinidine, verapamil; or
  • steroid medicine --dexamethasone, prednisone, methylprednisolone; medicine to prevent organ transplant rejection --cyclosporine, sirolimus, tacrolimus.

This list is not complete and many other drugs can interact with telaprevir. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

Where can I get more information?

Your pharmacist can provide more information about telaprevir.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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