|Pronunciation:||im IP ra meen|
Imipramine 10 mg-GG Back to top
round, yellow, imprinted with GG, 41
Imipramine 10 mg-MUT Back to top
round, yellow, imprinted with MP 4
Imipramine 10 mg-PAR Back to top
triangular, yellow, imprinted with par, 54
Imipramine 25 mg-GG Back to top
round, beige, imprinted with 47, GG
Imipramine 25 mg-PAR Back to top
round, brown, imprinted with 55, par
Imipramine 25 mg-URL Back to top
round, brown, imprinted with MP 8
Imipramine 50 mg-GG Back to top
round, green, imprinted with GG, 42
Imipramine 50 mg-MUT Back to top
round, green, imprinted with MP 79
Imipramine 50 mg-PAR Back to top
round, green, imprinted with 56, par
Imipramine Pamoate 100 mg-ROX Back to top
red/yellow, imprinted with 54758
Imipramine Pamoate 150 mg-ROX Back to top
red, imprinted with 54 161
Imipramine Pamoate 75 mg-ROX Back to top
red, imprinted with 54591
Tofranil 25 mg-MAL Back to top
round, orange, imprinted with M inside a box, 25
Tofranil 50 mg-MAL Back to top
round, orange, imprinted with 50, M inside a box
Tofranil 10 mg-MAL Back to top
triangular, orange, imprinted with 10, M inside a box
What is the most important information I should know about imipramine? Back to top
|Do not use imipramine if you have recently had a heart attack, or if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days.|
You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.
|Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.|
What is imipramine? Back to top
Imipramine is in a group of drugs called tricyclic antidepressants. Imipramine affects chemicals in the brain that may become unbalanced.
Imipramine is used to treat symptoms of depression.
Imipramine may also be used for purposes other than those listed in this medication guide.
What should I discuss with my healthcare provider before taking imipramine? Back to top
|Do not use this medication if you are allergic to imipramine, or if you have recently had a heart attack.|
|Do not use imipramine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take imipramine before the MAO inhibitor has cleared from your body.|
Before taking imipramine, tell your doctor if you are allergic to any drugs, or if you have:
- heart disease;
- a history of heart attack, stroke, or seizures;
- bipolar disorder (manic-depression);
- kidney or liver disease;
- overactive thyroid;
- diabetes (imipramine may raise or lower blood sugar);
- adrenal gland tumor (pheochromocytoma);
- glaucoma; or
- problems with urination.
If you have any of these conditions, you may not be able to use imipramine, or you may need a dosage adjustment or special tests during treatment.
You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Tell your doctor if you have worsening symptoms of depression or suicidal thoughts during the first several weeks of treatment, or whenever your dose is changed.
Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.
|This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.|
|Imipramine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.|
|Do not give this medication to anyone younger than 18 years old without the advice of a doctor.|
How should I take imipramine? Back to top
Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Your doctor may occasionally change your dose to make sure you get the best results from this medication. Follow the directions on your prescription label.
If you need to have any type of surgery, tell the surgeon ahead of time that you are taking imipramine. You may need to stop using the medicine for a short time.
|Do not stop using imipramine without first talking to your doctor. You may need to use less and less before you stop the medication completely. Stopping this medication suddenly could cause you to have unpleasant side effects.|
|It may take up to 3 weeks of using this medicine before your symptoms improve. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve after 3 weeks of treatment.|
|Store imipramine at room temperature away from moisture and heat.|
What happens if I miss a dose? Back to top
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.
What happens if I overdose? Back to top
|Seek emergency medical attention if you think you have used too much of this medicine. An overdose of imipramine can be fatal.|
Symptoms of an imipramine overdose may include uneven heartbeats, extreme drowsiness, agitation, vomiting, blurred vision, sweating, muscle stiffness, swelling, shortness of breath, blue lips or fingernails, feeling light-headed, fainting, seizure (convulsions), or coma.
What should I avoid while taking imipramine? Back to top
|Avoid drinking alcohol. It can cause dangerous side effects when taken together with imipramine.|
Avoid using other medicines that make you sleepy (such as cold medicine, pain medication, muscle relaxers, medicine for seizures, or other antidepressants). They can add to sleepiness caused by imipramine.
Grapefruit and grapefruit juice may interact with imipramine. Discuss the use of grapefruit products with your doctor before increasing or decreasing the amount of grapefruit products in your diet.
|Imipramine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.|
|Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Imipramine can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun.|
What are the possible side effects of imipramine? Back to top
|Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.|
Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
|Call your doctor at once if you have any of these serious side effects:|
- fast, pounding, or uneven heart rate;
- chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
- sudden numbness or weakness, especially on one side of the body;
- sudden headache, confusion, problems with vision, speech, or balance;
- feeling short of breath, even with mild exertion;
- swelling, rapid weight gain;
- confusion, hallucinations, or seizure (convulsions);
- easy bruising or bleeding, unusual weakness;
- restless muscle movements in your eyes, tongue, jaw, or neck;
- urinating more or less than usual;
- extreme thirst with headache, nausea, vomiting, and weakness;
- skin rash, bruising, severe tingling, numbness, pain, or muscle weakness.
Less serious side effects may be more likely to occur, such as:
- nausea, vomiting, stomach pain, loss of appetite;
- constipation or diarrhea;
- dry mouth, unpleasant taste;
- weight changes;
- weakness, lack of coordination;
- feeling dizzy, drowsy, or tired;
- blurred vision, headache, ringing in your ears;
- breast swelling (in men or women); or
- decreased sex drive, impotence, or difficulty having an orgasm.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect imipramine? Back to top
Before taking imipramine, tell your doctor if you have used an "SSRI" antidepressant in the past 5 weeks, such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), or sertraline (Zoloft).
Before taking imipramine, tell your doctor if you are currently using any of the following drugs:
- cimetidine (Tagamet);
- clonidine (Catapres);
- guanethidine (Ismelin);
- methylphenidate (Concerta, Ritalin, Daytrana); or
- heart rhythm medications such as flecainide (Tambocor), propafenone (Rhythmol), or quinidine (Cardioquin, Quinidex, Quinaglute).
If you are using any of these drugs, you may not be able to use imipramine, or you may need dosage adjustments or special tests during treatment.
There are many other medicines that can interact with imipramine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.
Where can I get more information? Back to top
Your pharmacist has information about imipramine written for health professionals that you may read.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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