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aldesleukin

Pronunciation: AL des LOO kin

Brand: Proleukin

What is the most important information I should know about aldesleukin?

Multum donot

You should not receive this medication if you are allergic to aldesleukin or interleukin-2, or if you have a bacterial infection, if you have received an organ transplant, or if you have recently had abnormal lung or heart function tests.

Multum donot

You may not be able to receive aldesleukin if prior treatment with this medication caused chest pain, irregular heart rhythm, a build-up of fluid around your heart, kidney failure, seizures, psychosis, stomach or intestinal bleeding, or if you needed a breathing tube.

Before you receive aldesleukin, tell your doctor if you have a heart disorder or history of heart attack, breathing problems, kidney or liver disease, gallbladder disease, high levels of calcium in your blood, a thyroid disorder, diabetes, seizures, mental illness, neurologic problems, or an autoimmune disorder (arthritis, Crohn's disease, scleroderma, myasthenia gravis, or skin disorder).

There are many other drugs that can interact with aldesleukin. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

Multum donot

If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, be sure the doctor knows ahead of time if you have recently received aldesleukin. Some people treated with aldesleukin or similar medication have had unusual allergic reactions to contrast agents used within weeks to several months later.

What is aldesleukin?

Aldesleukin is a cancer medication that interferes with tumor growth.

Aldesleukin is used to treat kidney cancer or skin cancer than has spread to other parts of the body.

Aldesleukin may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before receiving aldesleukin?

Multum donot

You should not receive this medication if you are allergic to aldesleukin or interleukin-2, or if you have:

  • an infection caused by bacteria;
  • if you have received an organ transplant;
  • if you have recently had an abnormal lung function test; or
  • if you have recently had an abnormal exercise test showing decreased blood flow to your heart.
Multum donot

You may not be able to receive aldesleukin if you have had any of these side effects while receiving aldesleukin in the past:

  • irregular heart rhythm;
  • chest pain;
  • a build-up of fluid around your heart;
  • kidney failure;
  • seizures;
  • psychosis (thinking problems, hallucinations, or changes in personality);
  • stomach or intestinal bleeding; or
  • if you needed a breathing tube.

To make sure you can safely receive aldesleukin, tell your doctor if you have any of these other conditions:

  • heart disease, angina (chest pain), a heart rhythm disorder, or history of heart attack;
  • lung or breathing problems;
  • kidney disease;
  • liver disease;
  • gallbladder disease;
  • high levels of calcium in your blood (hypercalcemia);
  • a thyroid disorder;
  • diabetes;
  • a seizure disorder;
  • mental illness or neurologic problems; or
  • an autoimmune disorder such as Crohn's disease, scleroderma, arthritis, myasthenia gravis, or a chronic skin disorder.
Multum nopreg

FDA pregnancy category C. It is not known whether aldesleukin will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

Multum nobrfeed

It is not known whether aldesleukin passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How is aldesleukin given?

Aldesleukin is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting. Aldesleukin must be given slowly, and the IV infusion can take at least 15 minutes to complete.

Aldesleukin is usually given every 8 hours for up to 5 days, followed by a 9-day rest period and then repeated.

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Your breathing, blood pressure, oxygen levels, kidney function, and other vital signs will be watched closely while you are receiving aldesleukin. Your blood will also need to be tested daily during treatment, and you may also need chest x-rays.

After 4 weeks off the medication, your doctor will examine you to determine if you need to be treated again with aldesleukin.

Multum donot

If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, be sure the doctor knows ahead of time if you have recently received aldesleukin. Some people treated with aldesleukin or similar medication have had unusual allergic reactions to contrast agents used within weeks to several months later.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your aldesleukin injection.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include confusion, hallucinations, fast or pounding heartbeats, chest pain, trouble walking or breathing, painful swelling in any part of your body, problems with vision or speech, urinating less than usual , or seizure (convulsions).

What should I avoid while receiving aldesleukin?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of aldesleukin?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

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Call your doctor at once if you have a serious side effect such as:

  • severe drowsiness;
  • feeling like you might pass out;
  • chest pain, fast or pounding heartbeats;
  • runny or stuffy nose, cough, rapid breathing and heart rate, trouble breathing, swelling and pain in any part of your body;
  • problems with vision, speech, balance, or coordination;
  • mood or behavior changes, confusion, agitation, hallucinations;
  • seizures (convulsions);
  • swelling, rapid weight gain;
  • black, bloody, or tarry stools;
  • urinating less than usual or not at all;
  • a blistering skin rash;
  • jaundice (yellowing of the skin or eyes); or
  • signs of infection such as fever, chills, sore throat, flu symptoms, easy bruising or bleeding (nosebleeds, bleeding gums), nausea and vomiting, mouth sores, unusual weakness.

Less serious side effects may include:

  • mild stomach pain;
  • tired feeling;
  • drowsiness, dizziness, anxiety; or
  • diarrhea, loss of appetite.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect aldesleukin?

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Before receiving aldesleukin, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, anxiety, or nausea and vomiting). They can add to sleepiness caused by aldesleukin.

Aldesleukin can harm your kidneys. This effect is increased when you also use other medicines harmful to the kidneys. You may need dose adjustments or special tests if you have recently used:

  • lithium (Eskalith, Lithobid);
  • methotrexate (Rheumatrex, Trexall);
  • pain or arthritis medicines such as aspirin (Anacin, Excedrin), acetaminophen (Tylenol), ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others;
  • medicines used to treat ulcerative colitis, such as mesalamine (Pentasa) or sulfasalazine (Azulfidine);
  • medicines used to prevent organ transplant rejection, such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune) or tacrolimus (Prograf);
  • IV antibiotics such as amphotericin B (Amphotec, AmBisome, Abelcet), amikacin (Amikin), bacitracin (Baci IM), capreomycin (Capastat), gentamicin (Garamycin), kanamycin (Kantrex), streptomycin, or vancomycin (Vancocin, Vancoled);
  • antiviral medicines such as acyclovir (Zovirax), adefovir (Hepsera), cidofovir (Vistide), foscarnet (Foscavir), ganciclovir (Cytovene), valacyclovir (Valtrex), or valganciclovir (Valcyte); or
  • cancer medicine such as carmustine (BiCNU, Gliadel), cisplatin (Platinol), ifosfamide (Ifex), oxaliplatin (Eloxatin), streptozocin (Zanosar), or tretinoin (Vesanoid).

This list is not complete and there are many other drugs that can interact with aldesleukin. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

Where can I get more information?

Your doctor or pharmacist can provide more information about aldesleukin.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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