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What is sleep apnea?
Sleep apnea means that your breathing often is blocked or partly blocked during sleep. The problem can be mild to severe, based on how often your lungs don't get enough air. This may happen from 5 to 30 or more times an hour.
This topic focuses on obstructive sleep apnea, which is the most common type.
A less common type of apnea, called central sleep apnea, can occur in people who have had a stroke, have heart failure, are on certain medicines (for example, opioids), or have a brain tumor or infection. Even though this topic isn't about central sleep apnea, some of the treatments discussed here may also help treat it. Talk with your doctor to find out more about central sleep apnea.
What causes obstructive sleep apnea?
Blocked or narrowed airways in your nose, mouth, or throat can cause sleep apnea. Your airways can become blocked when your throat muscles and tongue relax during sleep.
Sleep apnea can also occur if you have large tonsils or adenoids. During the day, when you are awake and standing up, these may not cause problems. But when you lie down at night, they can press down on your airway, narrowing it and causing sleep apnea. Sleep apnea can also occur if you have a problem with your jawbone.
In children, the main cause of sleep apnea is large tonsils or adenoids.
Sleep apnea is more likely to occur if you are overweight, use certain medicines or alcohol before bed, or sleep on your back.
What are the symptoms?
The main symptoms of sleep apnea that you may notice are:
- Not feeling rested after a night's sleep.
- Feeling sleepy during the day.
- Waking up with a headache.
Your bed partner may notice that while you sleep:
- You stop breathing.
- You often snore loudly.
- You gasp or choke.
- You toss and turn.
Children who have sleep apnea:
- Nearly always snore.
- May be hyperactive or have problems paying attention during the day.
- May be restless during sleep and wake up often. They also may have problems with bed-wetting.
But children may not seem very sleepy during the day (a key symptom in adults). The only symptom of sleep apnea in some children may be that they do not grow as quickly as most children their age.
Can sleep apnea cause other problems?
Having sleep apnea can lead to serious problems such as:
- High blood pressure.
- High blood pressure in your lungs.
- An abnormal heart rhythm, heart failure, coronary artery disease (CAD), or stroke.
If you have sleep apnea, you also may not be sleeping as well as you could. If you feel sleepy during the day and this gets in the way of the normal things you do (like work, school, or driving), it's important to talk to your doctor. Be safe. Do not drive while you are drowsy.
How is sleep apnea diagnosed?
Your doctor will probably examine you and ask about your past health. He or she may also ask you or your sleep partner about your snoring and sleep behavior and how tired you feel during the day.
Your doctor may suggest a sleep study. A sleep study usually takes place at a sleep center, where you will spend the night. Sleep studies find out how often you stop breathing or have too little air flowing into your lungs during sleep. They also find out how much oxygen you have in your blood during sleep. You may have blood tests and X-rays.
How is it treated?
You may be able to treat mild sleep apnea by making changes in how you live and the way you sleep. For example:
- Lose weight if you are overweight.
- Sleep on your side and not your back.
- Avoid alcohol and medicines such as sedatives before bed.
If lifestyle changes don't help sleep apnea, you may be able to use an oral breathing device or other types of devices. These devices help keep your airways open while you sleep.
Sleep apnea is often treated with a machine that helps you breathe while you sleep. This treatment is called continuous positive airway pressure, or CPAP (say "SEE-pap"). Sometimes medicine that helps you stay awake during the day may be used along with CPAP. If your tonsils, adenoids, uvula, or other tissues are blocking your airway, your doctor may suggest surgery to open your airway.
Frequently Asked Questions
Learning about obstructive sleep apnea (OSA):
Health Tools help you make wise health decisions or take action to improve your health.
Obstructive sleep apnea usually occurs when the throat muscles and tongue relax during sleep and partially or completely block the airway. When you stop breathing or have reduced flow of air into your lungs during sleep, the amount of oxygen in your blood decreases briefly.
Bone deformities, enlarged tissues
Obstructive sleep apnea can also occur if you have bone deformities or enlarged tissues in your nose, mouth, or throat. For example, you may have enlarged tonsils. During the day when you are awake and standing up, this may not cause problems. But when you lie down at night, the tonsils can press down on your airway, narrowing it and causing sleep apnea.
In children, the main cause of sleep apnea is large tonsils or adenoids.
Other things that may contribute to sleep apnea include:
- Drinking alcohol, which affects the part of the brain that controls breathing. This may relax the breathing muscles and cause a narrowing of the airway and sleep apnea.
- Obesity. Fat in the neck area can press down on the tissues around the airways. This narrows the airways and can cause sleep apnea.
- Some medicines that are taken for conditions such as allergies, long-term pain, insomnia, or anxiety. These medicines, such as opioids, can also relax the muscles and tissues in the throat, causing it to narrow.
With sleep apnea, there are symptoms that you may notice and symptoms that others may notice when you're asleep.
Symptoms you may notice include:
- Excessive daytime sleepiness.
- Waking with an unrefreshed feeling after sleep, having problems with memory and concentration, feeling tired, and experiencing personality changes.
- Morning or night headaches. About half of all people with sleep apnea report headaches.footnote 1
- Heartburn or a sour taste in the mouth at night.
- Swelling of the legs.
- Getting up often during the night to urinate.
- Sweating and chest pain while you are sleeping.
Symptoms others may notice include:
- Episodes of not breathing (apnea), which may occur as few as 5 times an hour (mild apnea) to 30 or more times an hour (severe apnea). How many episodes you have determines how severe your sleep apnea is.
- Loud snoring. Almost all people who have sleep apnea snore. But not all people who snore have sleep apnea.
- Restless tossing and turning during sleep.
- Nighttime choking or gasping spells.
Symptoms in children
Children who have sleep apnea nearly always snore. But they may not appear to be excessively sleepy during the day (a key symptom in adults).
In children younger than 5, other symptoms include:
- Mouth breathing.
- Waking up a lot.
In children 5 years and older, other symptoms include:
- Bed wetting.
- Doing poorly in school.
- Not growing as quickly as they should for their age. This may be the only symptom in some children. These children may also have behavior problems and a short attention span.
Other conditions with symptoms similar to sleep apnea include other sleep disorders and an underactive thyroid.
Obstructive sleep apnea causes your airway to narrow or close off, reducing or stopping breathing for short periods during sleep.
If your breathing stops, you may make grunting, gasping, or snorting sounds and restless body movements. As breathing resumes, loud snoring starts. This may happen many times during a night.
The more often it happens, the more severe your sleep apnea is. Sleep apnea is called either mild, moderate, or severe.
When you stop breathing, the oxygen levels in your blood go down and carbon dioxide levels go up. This makes your heart and blood vessels work harder and can affect your heart rate and nervous system. That in turn may:
- Lead to other problems, such as high blood pressure and heart disease.
- Make these other problems worse and harder to treat.
- Raise your risk of having a stroke.footnote 2
- Make it harder for people with diabetes to control blood sugar.
Because sleep apnea disturbs your sleep, it can make you very tired during the day. So if you have sleep apnea, you may:
- Be more likely to have a car accident.
- Do poorly at school or work and have trouble concentrating.
- Have memory problems.
- Have personality changes, anxiety, and depression.
- Lose the desire for sex.
What Increases Your Risk
Certain things make it more or less likely that you will have obstructive sleep apnea. Some of these you cannot change, while others you can.
Things you can't change
- Aging. Sleep apnea is most common in people age 30 and older.
- Being male. Sleep apnea is more common in men.
- Family history. If other members of your family have sleep apnea, you are more likely to have it than someone who doesn't have a family history of it.
- Ethnicity. Hispanics and Pacific Islanders have a greater risk of sleep apnea than whites. Blacks tend to get sleep apnea at a younger age than whites.
- Deformities of the spine. Deformities of the spine, such as scoliosis, may interfere with breathing and contribute to sleep apnea.
- Conditions that may cause head and face abnormalities. Conditions such as Marfan's syndrome and Down syndrome may result in abnormalities and increase the risk for sleep apnea.
- Menopause. Sleep apnea tends to occur more often in women who have been through menopause than in women who have not. After menopause, women get sleep apnea at a rate similar to men.footnote 1 Experts don't know why or how menopause increases the risk of sleep apnea.
Things you may be able to change
- Obesity. People who have sleep apnea are more likely to be obese. Obesity is the factor most likely to lead to sleep apnea.
- Neck circumference. People who are overweight may have extra tissue around their neck, adding to their risk for sleep apnea. The risk increases for a man whose neck measures more than 17 inches around and for a woman whose neck measures more than 16 inches around.
- Enlarged tissues of the nose, mouth, or throat. Enlarged tissues in the nose, mouth, or throat can block your airway while you sleep, making sleep apnea more likely. Surgery can sometimes correct the blockage and improve sleep apnea.
- Bone deformities. Bone deformities of the nose, mouth, or throat can interfere with breathing, causing sleep apnea. Some people who have sleep apnea have a small, receding jaw. Surgery can sometimes correct these deformities and improve sleep apnea.
- Use of alcohol or medicine. Drinking alcohol or taking certain medicines before going to sleep can increase the risk for sleep apnea. Medicines include some types of sleeping pills and sedatives.
- Sleeping on your back and using pillows. Sleeping on your back and using one or more pillows may make sleep apnea worse.
- Smoking. Smoking can increase your risk for sleep apnea, because the nicotine in tobacco relaxes the muscles that keep the airways open.
- Poor sleep habits. For example, going to bed in different places may increase your risk for sleep apnea.
- Disorders of the hormone (endocrine) system. Disorders that may increase your risk include hypothyroidism and acromegaly.
When To Call a Doctor
Call your doctor if:
- You or your bed partner snores loudly and heavily and feels sleepy during the day.
- You notice that your bed partner stops breathing, gasps, or chokes during sleep.
- You sometimes fall asleep at inappropriate times, such as while you are talking or eating. Do not drive when you are drowsy.
- Your child snores, has trouble breathing while sleeping, sleeps restlessly, wakes up often, or is very sleepy during the day.
Watchful waiting is a wait-and-see approach. If you get better on your own, you will not need treatment. If you get worse, you and your doctor will decide what to do next. Watchful waiting may be right for you if you snore but are not excessively sleepy during the day.
Watchful waiting may not be right if you notice that your sleep partner snores loudly and heavily, is restless during sleep, and is sleepy during the day. If you think your sleep partner may have periods when breathing stops, suggest that he or she talk with a doctor.
Who to see
Health professionals who can check people who have symptoms of obstructive sleep apnea include:
- Family medicine physicians.
- Sleep disorders specialists.
- Nurse practitioners.
- Physician assistants.
Other health professionals may be able to help you if you have other problems that are caused by sleep apnea. If you:
- Have heart problems, you may see a cardiologist.
- Need surgery to remove excess tissue or to correct a defect or injury, you may see an ear, nose, and throat doctor (otolaryngologist).
- Need oral breathing devices, you may see a dentist.
To prepare for your appointment, see the topic Making the Most of Your Appointment.
Exams and Tests
Your doctor will examine you and ask you and possibly your sleep partner some questions about your lifestyle, snoring, sleep behavior, and how tired you feel during the day (this is called a medical history).
Your doctor may ask you to complete a questionnaire, such as the Epworth Sleepiness Scale. The answers to questions in this questionnaire can help the doctor find out if you have sleep apnea. If your doctor thinks that you may have sleep apnea, he or she may suggest that you have a sleep study in a lab or at your home.
Sleep studies are a series of tests that record what happens to your body during sleep. Polysomnography is the main way to detect sleep apnea. This test records electrical activity of your brain, eye movement, muscle activity, heart rate, breathing, airflow through your nose and mouth, and blood oxygen levels (saturation).
Other tests that you may have include:
- Blood tests to check for hypothyroidism (TSH test) or an abnormal red blood cell count (complete blood count).
- Electrocardiogram (EKG, ECG) or echocardiogram to see if sleep apnea has affected your heart.
Diagnosing sleep apnea in children
Most doctors follow these guidelines from the American Academy of Pediatrics:footnote 3
- During a routine checkup, your doctor will ask you and your child about snoring. If your child snores, be sure to tell your doctor.
- A complete sleep study typically is needed to find out if your child has sleep apnea and is not just snoring.
- Children who have sleep apnea and other disorders, such as Down syndrome or sickle cell disease, may need to see a specialist.
Testing after initial treatment
To see how well your treatment is working, you may need sleep tests after treatment begins.
If your sleep apnea has not improved after initial treatment, and if enlarged tissues in your mouth and throat are causing it, your doctor may do one or more tests before suggesting surgery to remove the excess tissue. These tests may include:
- Fiber-optic pharyngoscopy, to see whether your airway is too narrow or collapses during breathing.
- CT scan of the head to look for an overly large tongue and excessive soft tissue in the neck, as well as to locate the narrowest part of your airway.
- X-rays. A cephalometric X-ray is a type of head X-ray that allows your doctor to see bone deformities of the skull. This type of X-ray test may not be available in every hospital.
Treatment for obstructive sleep apnea may include:
- Lifestyle changes, such as losing weight. For more information, see Home Treatment.
- Continuous positive airway pressure (CPAP) or a similar machine that uses positive airway pressure to help you breathe.
- Oral breathing devices or other devices (such as nasal dilators) that you wear at night.
- Medicine to help you stay awake during the day. For more information, see Medications.
- Surgery. For more information, see Surgery.
Your doctor will probably have you try lifestyle changes and CPAP first. Surgery might be a first choice only if the sleep apnea is caused by a blockage that is easily fixed.
Continuous positive airway pressure
CPAP is nearly always the first medical treatment for sleep apnea. With CPAP, you use a breathing machine that prevents your airways from closing during sleep.
Research shows that:
- CPAP decreases daytime sleepiness.footnote 4, footnote 5, footnote 6 If you still feel sleepy during the day while using CPAP at night, tell your doctor.
- CPAP can lower daytime and nighttime blood pressure.footnote 7
It may take time for you to be comfortable using CPAP. You may find that you want to take off the mask, or you may find it hard to sleep. If you can't get used to CPAP, talk to your doctor. You might be able to try another type of mask or make other adjustments.
Some CPAP devices automatically adjust air pressure or use different air pressures when you breathe in or out. They are easier and more comfortable for some people to use.
If you use CPAP to treat sleep apnea, you need to use it every night and while you nap. If you don't use it, your symptoms will return right away.
Other devices to help you breathe
Oral breathing devices reposition your tongue and jaw during sleep, which opens up your airways. They may be used for people who have mild to moderate sleep apnea. They may also be used for people with severe sleep apnea who try CPAP but find out that it does not work out for them. A dentist will shape the device to fit your mouth.
Your doctor may suggest that you use nasal dilators (such as nose strips or disks) to help keep your airways open while you sleep. Nose strips widen the nostrils and improve airflow. Nasal disks have a valve that makes it harder for you to breathe out. This causes a little back-pressure in the airways that may help keep them open. You can get many of these devices without a prescription. Talk to your doctor or pharmacist about your options.
Treatment for other health problems
You may need to be treated for other health problems before you are treated for sleep apnea. For example:
- People who also have inflammation of the nasal passages (rhinitis) may need to use nose spray to reduce the inflammation.
- People who have an underactive thyroid gland (hypothyroidism) need to take thyroid medicine.
You may also need treatment for problems that sleep apnea may cause, such as high blood pressure.
Treatment for children
Children have most of the same treatment options as adults.
- Children who are overweight are encouraged to lose weight.
- Surgery (removing tonsils or adenoids) typically is the first choice, because enlarged tonsils or adenoids cause most cases of sleep apnea in children.footnote 3
- If surgery isn't possible or doesn't work, children are treated using CPAP or may use corticosteroid medicine through the nose.footnote 3 In some cases, getting braces that widen the mouth can help children who have sleep apnea.
You can help prevent obstructive sleep apnea if you:
- Don't use alcohol and medicines, such as sleeping pills and sedatives, before bed. These can relax your throat muscles and slow your breathing.
- Eat sensibly, exercise, and stay at a healthy weight.
- Quit smoking. The nicotine in tobacco relaxes the muscles that keep the airways open. If you don't smoke, those muscles are less likely to collapse at night and narrow the airways.
Home treatment for obstructive sleep apnea includes lifestyle changes and changing some sleeping habits.
- Lose weight. Experts agree that weight loss should be part of managing sleep apnea.footnote 5 If you are overweight and have sleep apnea, nutritional counseling and other treatments may help.
- Limit the use of alcohol and medicine. Drinking excessive amounts of alcohol or taking certain medicines, especially sleeping pills or sedatives, before sleep may make symptoms worse.
- Get plenty of sleep. Apnea episodes may be more frequent when you have not had enough sleep.
- Quit smoking. The nicotine in tobacco relaxes the muscles that keep the airways open. If you don't smoke, those muscles are less likely to collapse at night and narrow the airways.
- Promptly treat breathing problems, such as a stuffy nose caused by a cold or allergies.
One study found that people with sleep apnea who tend to have fluid collect in their lower legs and ankles may be helped by wearing compression stockings during the day.footnote 8 Keeping the fluid from collecting in the legs during the day may prevent the fluid from causing swelling of tissues in the nose and throat at night.
Sleeping habit changes
- Sleep on your side. Try this: Sew a pocket in the middle of the back of your pajama top, put a tennis ball into the pocket, and stitch it shut. This will help keep you from sleeping on your back. Sleeping on your side may eliminate mild sleep apnea.
- Raise the head of your bed 4 in. (10 cm) to 6 in. (15 cm) by putting bricks under the legs of the bed. You can also use a special pillow (called a cervical pillow) when you sleep. A cervical pillow can help your head stay in a position that reduces sleep apnea. Using regular pillows to raise your head and upper body won't work.
- Use your CPAP machine every night. If you are using a continuous positive airway pressure (CPAP) machine to help you breathe, use it every night. If you don't use it all night, every night, your symptoms will return right away.
Your doctor may also suggest that you use a breathing device while you sleep. It helps keep your airways open. This could be a device that you put in your mouth. Other examples include strips or disks that you use on your nose.
Talk to your doctor if you are sleepy during the day and this gets in the way of the normal things you do. It's important that you do not drive or operate machinery while you are drowsy.
Doctors typically don't suggest using medicines to treat obstructive sleep apnea. Children may be given intranasal corticosteroid medicine for mild sleep apnea if surgery cannot be done or if the surgery did not work.footnote 3
But medicine can help reduce daytime sleepiness when continuous positive airway pressure (CPAP) is reducing the number of times you stop breathing at night but you still feel sleepy during the day.footnote 9, footnote 10
People with sleep apnea who take these medicines to reduce daytime sleepiness should keep using CPAP to treat sleep apnea.
Surgery for obstructive sleep apnea usually isn't done unless other treatments have failed or you are unable or choose not to use other treatments.
- Uvulopalatopharyngoplasty (UPPP). This is the most common surgery to treat sleep apnea in adults.
- Tonsillectomy and/or adenoidectomy. This is often the first treatment option for children, because enlarged tonsils and adenoids are usually the cause of their sleep apnea.
- Tracheostomy. Although this is effective at treating sleep apnea, it is done only when other treatments have failed or when treatment is needed right away.
- Maxillo-mandibular advancement (MMA). This moves the upper and lower jaw forward to increase the size of the airway.
- Radiofrequency ablation (RFA). This reduces the size of the tongue and other tissues that may be blocking airflow to the lungs.
- Palatal implants. These are small plastic rods that are implanted in the soft palate. They make the soft palate stiffer to keep the tissue from blocking the airway.
- Other surgical procedures to repair bone and tissue problems in the mouth and throat.
- Bariatric surgery. This surgery can promote weight loss that improves sleep apnea.footnote 11
- Nerve stimulation. A device is implanted in the upper chest. It senses the breathing pattern and mildly stimulates the airway muscles to keep the airway open.
What to think about
If you are thinking about having surgery to treat sleep apnea, talk with your doctor about having a sleep study done first.
Experts typically suggest that you try continuous positive airway pressure (CPAP) before considering surgery.
Laser-assisted uvulopalatoplasty uses a laser to perform surgery. It is sometimes used to treat mild to moderate sleep apnea, although not all people benefit. This surgery is not recommended by the American Academy of Sleep Medicine to treat sleep apnea.footnote 12
Other Places To Get Help
- Guilleminault C, Abad VC (2004). Obstructive sleep apnea syndromes. Medical Clinics of North America, 88(3): 611–630.
- Arzt M, et al. (2005). Association of sleep-disordered breathing and the occurrence of stroke. American Journal of Respiratory and Clinical Care Medicine, 172(11): 1447–1451.
- Marcus CL, et al. (2012). Diagnosis and management of childhood obstructive sleep apnea syndrome. Pediatrics, 130(3): 576–584.
- Giles TL, et al. (2006). Continuous positive airways pressure for obstructive sleep apnoea in adults. Cochrane Database of Systematic Reviews (3).
- Hensley M, Ray C (2009). Sleep apnoea, search date May 2008. Online version of BMJ Clinical Evidence: http://www.clinicalevidence.com.
- Weaver TE, et al. (2012). Continuous positive airway pressure treatment of sleepy patients with milder obstructive sleep apnea: Results of the CPAP Apnea Trial North American Program (CATNAP) randomized clinical trial. American Journal of Respiratory and Critical Care Medicine, 186(7): 677–683.
- Marin JM, et al. (2012). Association between treated and untreated obstructive sleep apnea and risk of hypertension. JAMA, 307(20): 2169–2176.
- Redolfi S, et al. (2011). Attenuation of obstructive sleep apnea by compression stockings in subjects with venous insufficiency. American Journal of Respiratory and Critical Care Medicine, 184(9): 1062–1066.
- Schwartz JRL, et al. (2003). Modafinil as adjunct therapy for daytime sleepiness in obstructive sleep apnea: A 12-week, open-label study. Chest, 124(6): 2192–2199.
- Hirshkowitz M, et al. (2007). Adjunct armodafinil improves wakefulness and memory in obstructive sleep apnea/hypopnea syndrome. Respiratory Medicine, 101(3): 616–627.
- Buchwald H, et al. (2004). Bariatric surgery: A systematic review and meta-analysis. JAMA, 292(14): 1724–1737.
- Aurora RN, et al. (2010). Practice parameters for the surgical modifications of the upper airway for obstructive sleep apnea in adults. Sleep, 33(10): 1408–1413.
Other Works Consulted
- Adult Obstructive Sleep Apnea Task Force for the American Academy of Sleep Medicine (2009). Clinical guideline for the evaluation, management and long-term care of obstructive sleep apnea in adults. Journal of Clinical Sleep Medicine, 5(3): 263–276. http://www.aasmnet.org/Resources/clinicalguidelines/OSA_Adults.pdf. Accessed October 10, 2013.
- Campos-Rodriguez F, et al. (2012). Cardiovascular mortality in women with obstructive sleep apnea with or without continuous positive airway pressure treatment: A cohort study. Annals of Internal Medicine, 156(2): 115–122.
- Collop NA, et al. (2007). Clinical guidelines for the use of unattended portable monitors in the diagnosis of obstructive sleep apnea in adult patients. Journal of Clinical Sleep Medicine, 3(7): 737–747.
- Holley AB, et al. (2011). Efficacy of an adjustable oral appliance and comparison with continuous positive airway pressure for the treatment of obstructive sleep apnea syndrome. Chest, 140(6): 1511–1516.
- Kushida CA, et al. (2006). Practice parameters for the treatment of snoring and obstructive sleep apnea with oral appliances: An update for 2005. Sleep, 29(2): 240–243.
- Kushida CA, et al. (2006). Practice parameters for the use of continuous and bilevel positive airway pressure devices to treat adult patients with sleep-related breathing disorders. Sleep, 29(3): 375–380.
- Kushida CA, et al. (2008). Clinical guidelines for the manual titration of positive airway pressure in patients with obstructive sleep apnea. Journal of Clinical Sleep Medicine, 4(2): 151–171.
- Qaseem A, et al. (2013). Management of obstructive sleep apnea in adults: A clinical practice guideline from the American College of Physicians. Annals of Internal Medicine, 159(7): 471–483. DOI: 10.7326/0003-4819-159-7-201310010-00704. Accessed October 7, 2013.
- U.S. Department of Health and Human Services, et al. (2005, revised 2011). Your Guide to Healthy Sleep (NIH Publication No. 11-5271). Available online: http://www.nhlbi.nih.gov/health/public/sleep/healthy_sleep.htm.
- Zaghi S, et al. (2016). Maxillomandibular advancement for treatment of obstructive sleep apnea: A meta-analysis. JAMA Otolaryngology—Head and Neck Surgery, 142(1): 58–66. DOI: 10.1001/jamaoto.2015.2678. Accessed February 8, 2016.
Primary Medical Reviewer Anne C. Poinier, MD - Internal Medicine
E. Gregory Thompson, MD - Internal Medicine
Adam Husney, MD - Family Medicine
Kathleen Romito, MD - Family Medicine
Specialist Medical Reviewer Hasmeena Kathuria, MD - Pulmonology, Critical Care Medicine, Sleep Medicine
Current as ofNovember 10, 2016
Current as of: November 10, 2016
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