Nonalcoholic steatohepatitis, or NASH, is inflammation of the liver
caused by a buildup of fat in liver cells. NASH has features similar to
alcohol-induced liver disease, but it occurs in people who do not abuse
The exact cause of NASH is not known. NASH is part of a group of
liver diseases known as nonalcoholic fatty liver disease (NAFLD). In this group
of diseases, fat builds up in the liver and sometimes causes liver damage that
gets worse over time (progressive liver damage). People who get NASH are
usually middle-aged and overweight or obese and often have other conditions
such as diabetes. But NASH can occur in a person who has none of these risk
Many people with NASH have no symptoms and do not know that they
have the condition. As NASH gets worse, symptoms may appear and include being
tired all the time and having unexplained weight loss and general
Treatment for NASH may include reducing cholesterol levels, losing weight, and controlling
diabetes. Treatment may also include stopping the use of medicines that may make symptoms worse.
E. Gregory Thompson, MD - Internal Medicine & W. Thomas London, MD - Hepatology
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