Vincent L. Cryns, MD Print Friendly Page
Dr. Cryns is Chief of the Division of Endocrinology, Diabetes and Metabolism. His major clinical interests are osteoporosis, general endocrinology and metabolic disorders.
UW Health Clinics
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UW School of Medicine and Public Health
|Department of Medicine|
Professional Certifications and Education
Endocrinology, Diabetes & Metabolism
Massachusetts General Hospital, Boston
Dartmouth Hitchcock Medical Center, Lebanon, NH
Massachusetts General Hospital, Boston
Harvard Medical School, Boston, MA, 1987
Dr. Cryns' research focuses on understanding how cells die. He leads a team of scientists who are interested in understanding how abnormalities in cell death contribute to cancer and obesity and in translating these insights into improved therapies. Dr. Cryns' research is funded by the NIH, the Breast Cancer Research Foundation, and other agencies. His work has been featured on National Public Radio's "All Things Considered" and highlighted in Nature and Nature Reviews Cancer. Dr. Cryns has been the recipient of several awards, including an Outstanding Junior Faculty Award from the Avon Foundation, and he is an elected member of the American Society for Clinical Investigation.
Malin D Strekalova E Petrovic V Deal AM Al Ahmad A Adamo B Miller CR Ugolkov A Livasy C Fritchie K Hamilton EP Blackwell K Geradts J Ewend M Carey LA Shusta EV Anders CK Cryns VL .
αB-crystallin: a Novel Regulator of Breast Cancer Metastasis to the Brain. Clin Cancer Res. 2013 Oct 16;
[PubMed ID: 24132917]
Frasconi M Liu Z Lei J Wu Y Strekalova E Malin D Ambrogio MW Chen X Botros YY Cryns VL Sauvage JP Stoddart JF .
Photoexpulsion of surface-grafted ruthenium complexes and subsequent release of cytotoxic cargos to cancer cells from mesoporous silica nanoparticles. J Am Chem Soc. 2013 Aug 7;135(31):11603-13
[PubMed ID: 23815127]
Petrovic V Malin D Cryns VL .
αB-crystallin promotes oncogenic transformation and inhibits caspase activation in cells primed for apoptosis by Rb inactivation. Breast Cancer Res Treat. 2013 Apr;138(2):415-25
[PubMed ID: 23471649]
Goldberg MS Hook SS Wang AZ Bulte JW Patri AK Uckun FM Cryns VL Hanes J Akin D Hall JB Gharkholo N Mumper RJ .
Biotargeted nanomedicines for cancer: six tenets before you begin. Nanomedicine (Lond). 2013 Feb;8(2):299-308
[PubMed ID: 23394158]
Toft DJ Moyer TJ Standley SM Ruff Y Ugolkov A Stupp SI Cryns VL .
Coassembled cytotoxic and pegylated peptide amphiphiles form filamentous nanostructures with potent antitumor activity in models of breast cancer. ACS Nano. 2012 Sep 25;6(9):7956-65
[PubMed ID: 22928955]
Soukasene S Toft DJ Moyer TJ Lu H Lee HK Standley SM Cryns VL Stupp SI .
Antitumor activity of peptide amphiphile nanofiber-encapsulated camptothecin. ACS Nano. 2011 Nov 22;5(11):9113-21
[PubMed ID: 22044255]
Su J Chen F Cryns VL Messersmith PB .
Catechol polymers for pH-responsive, targeted drug delivery to cancer cells. J Am Chem Soc. 2011 Aug 10;133(31):11850-3
[PubMed ID: 21751810]
Malin D Chen F Schiller C Koblinski J Cryns VL .
Enhanced metastasis suppression by targeting TRAIL receptor 2 in a murine model of triple-negative breast cancer. Clin Cancer Res. 2011 Aug 1;17(15):5005-15
[PubMed ID: 21653692]
Toft DJ Cryns VL .
Minireview: Basal-like breast cancer: from molecular profiles to targeted therapies. Mol Endocrinol. 2011 Feb;25(2):199-211
[PubMed ID: 20861225]
Antin JH Aplin AE Cheng SY Emmert-Buck MR Cryns VL Wang D .
American journal of cancer research: editorial board (2011). Am J Cancer Res. 2011;1(6):817-22
[PubMed ID: 22016829]
Antin JH Emmert-Buck MR Aplin AE Cheng SY Cryns VL Wang D .
Launching of American Journal of Cancer Research. Am J Cancer Res. 2011;1(1):i
[PubMed ID: 21969259]
Oshita SE Chen F Kwan T Yehiely F Cryns VL .
The small heat shock protein HspB2 is a novel anti-apoptotic protein that inhibits apical caspase activation in the extrinsic apoptotic pathway. Breast Cancer Res Treat. 2010 Nov;124(2):307-15
[PubMed ID: 20087649]
Lee SM Ahn RW Chen F Fought AJ O'Halloran TV Cryns VL Nguyen ST .
Biological evaluation of pH-responsive polymer-caged nanobins for breast cancer therapy. ACS Nano. 2010 Sep 28;4(9):4971-8
[PubMed ID: 20738118]
Ahn RW Chen F Chen H Stern ST Clogston JD Patri AK Raja MR Swindell EP Parimi V Cryns VL O'Halloran TV .
A novel nanoparticulate formulation of arsenic trioxide with enhanced therapeutic efficacy in a murine model of breast cancer. Clin Cancer Res. 2010 Jul 15;16(14):3607-17
[PubMed ID: 20519360]
Evans JR Bosman JD Brown-Endres L Yehiely F Cryns VL .
Induction of the small heat shock protein alphaB-crystallin by genotoxic stress is mediated by p53 and p73. Breast Cancer Res Treat. 2010 Jul;122(1):159-68
[PubMed ID: 19777343]
Standley SM Toft DJ Cheng H Soukasene S Chen J Raja SM Band V Band H Cryns VL Stupp SI .
Induction of cancer cell death by self-assembling nanostructures incorporating a cytotoxic peptide. Cancer Res. 2010 Apr 15;70(8):3020-6
[PubMed ID: 20354185]
Bosman JD Yehiely F Evans JR Cryns VL .
Regulation of alphaB-crystallin gene expression by the transcription factor Ets1 in breast cancer. Breast Cancer Res Treat. 2010 Jan;119(1):63-70
[PubMed ID: 19205872]
Ivanov O Chen F Wiley EL Keswani A Diaz LK Memmel HC Rademaker A Gradishar WJ Morrow M Khan SA Cryns VL .
alphaB-crystallin is a novel predictor of resistance to neoadjuvant chemotherapy in breast cancer. Breast Cancer Res Treat. 2008 Oct;111(3):411-7
[PubMed ID: 17968656]
Strohecker AM Yehiely F Chen F Cryns VL .
Caspase cleavage of HER-2 releases a Bad-like cell death effector. J Biol Chem. 2008 Jun 27;283(26):18269-82
[PubMed ID: 18420586]
Lu M Strohecker A Chen F Kwan T Bosman J Jordan VC Cryns VL .
Aspirin sensitizes cancer cells to TRAIL-induced apoptosis by reducing survivin levels. Clin Cancer Res. 2008 May 15;14(10):3168-76
[PubMed ID: 18483385]