Timothy J. Kamp, MD, PhD, FACC Print Friendly Page
Faculty, University of Wisconsin School of Medicine and Public HealthDr. Kamp's clinical activities include general cardiology with an emphasis on noninvasive cardiac electrophysiology and heart failure. He directs an active research program which bridges from the basic functional and electrical properties of heart cells to clinical applications arising from these basic studies, including the use of stem cells to repair damaged heart muscle. Dr. Kamp participates widely in peer review activities, including the editorial board for the journals Circulation Research and Stem Cells, as well as serving on peer review panels for American Heart Association and National Institutes of Health.
Specialties
UW Health Clinics
Hospital Affiliation(s)
University of Wisconsin Hospital and Clinics (primary)
Meriter Hospital, Veterans Hospital - Wm. S. Middleton Memorial (secondary)
Languages Spoken
| English |
| Medical interpreters are available to help patients communicate with hospital and clinic staff. For more information, please contact interpreter services at (608) 262-9000. |
UW School of Medicine and Public Health
| Department of Medicine |
Professional Certifications and Education
| Board Certification |
Internal Medicine
Cardiovascular Disease |
| Fellowship |
Johns Hopkins Hospital, Baltimore, MD
|
| Residency |
Johns Hopkins Hospital, Baltimore, MD
|
| Internship |
Johns Hopkins Hospital, Baltimore, MD
|
| Medical School |
University of Chicago, Chicago, IL, 1989
|
Programs & Conditions
| Research |
Dr. Kamp's research focuses in three general and related areas: (1) cardiac ion channel proteins and their role in the electrical activity of the heart, including arrhythmias, (2) basic cellular abnormalities responsible for heart failure, and (3) stem cells for the generation of new heart cells and for repair of damaged heart muscle. |
PubMed Articles
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Lian X Zhang J Zhu K Kamp TJ Palecek SP .
Insulin inhibits cardiac mesoderm, not mesendoderm, formation during cardiac differentiation of human pluripotent stem cells and modulation of canonical Wnt signaling can rescue this inhibition. Stem Cells. 2013 Mar;31(3):447-57
[PubMed ID: 23193013]
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Lian X Zhang J Azarin SM Zhu K Hazeltine LB Bao X Hsiao C Kamp TJ Palecek SP .
Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions. Nat Protoc. 2013 Jan;8(1):162-75
[PubMed ID: 23257984]
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Zhang J Klos M Wilson GF Herman AM Lian X Raval KK Barron MR Hou L Soerens AG Yu J Palecek SP Lyons GE Thomson JA Herron TJ Jalife J Kamp TJ .
Extracellular matrix promotes highly efficient cardiac differentiation of human pluripotent stem cells: the matrix sandwich method. Circ Res. 2012 Oct 12;111(9):1125-36
[PubMed ID: 22912385]
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Lian X Hsiao C Wilson G Zhu K Hazeltine LB Azarin SM Raval KK Zhang J Kamp TJ Palecek SP .
Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling. Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):E1848-57
[PubMed ID: 22645348]
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Best JM Kamp TJ .
Different subcellular populations of L-type Ca2+ channels exhibit unique regulation and functional roles in cardiomyocytes. J Mol Cell Cardiol. 2012 Feb;52(2):376-87
[PubMed ID: 21888911]
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Squirrell JM Fong JJ Ariza CA Mael A Meyer K Shevde NK Roopra A Lyons GE Kamp TJ Eliceiri KW Ogle BM .
Endogenous fluorescence signatures in living pluripotent stem cells change with loss of potency. PLoS One. 2012;7(8):e43708
[PubMed ID: 22952742]
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Joers V Seneczko K Goecks NC Kamp TJ Hacker TA Brunner KG Engle JW Barnhart TE Nickles RJ Holden JE Emborg ME .
Nonuniform cardiac denervation observed by 11C-meta-hydroxyephedrine PET in 6-OHDA-treated monkeys. PLoS One. 2012;7(4):e35371
[PubMed ID: 22539969]
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Kouris NA Schaefer JA Hatta M Freeman BT Kamp TJ Kawaoka Y Ogle BM .
Directed Fusion of Mesenchymal Stem Cells with Cardiomyocytes via VSV-G Facilitates Stem Cell Programming. Stem Cells Int. 2012;2012:414038
[PubMed ID: 22701126]
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Ma J Guo L Fiene SJ Anson BD Thomson JA Kamp TJ Kolaja KL Swanson BJ January CT .
High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents. Am J Physiol Heart Circ Physiol. 2011 Nov;301(5):H2006-17
[PubMed ID: 21890694]
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Cai W Zhang Y Kamp TJ .
Imaging of Induced Pluripotent Stem Cells: From Cellular Reprogramming to Transplantation. Am J Nucl Med Mol Imaging. 2011 Aug 1;1(1):18-28
[PubMed ID: 21841970]
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Buschke DG Squirrell JM Ansari H Smith MA Rueden CT Williams JC Lyons GE Kamp TJ Eliceiri KW Ogle BM .
Multiphoton flow cytometry to assess intrinsic and extrinsic fluorescence in cellular aggregates: applications to stem cells. Microsc Microanal. 2011 Aug;17(4):540-54
[PubMed ID: 20684798]
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Best JM Foell JD Buss CR Delisle BP Balijepalli RC January CT Kamp TJ .
Small GTPase Rab11b regulates degradation of surface membrane L-type Cav1.2 channels. Am J Physiol Cell Physiol. 2011 May;300(5):C1023-33
[PubMed ID: 21248079]
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Kamp TJ .
An electrifying iPSC disease model: long QT syndrome type 2 and heart cells in a dish. Cell Stem Cell. 2011 Feb 4;8(2):130-1
[PubMed ID: 21295269]
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Balijepalli RC Kamp TJ .
Cardiomyocyte transverse tubule loss leads the way to heart failure. Future Cardiol. 2011 Jan;7(1):39-42
[PubMed ID: 21174508]
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Su X Young EW Underkofler HA Kamp TJ January CT Beebe DJ .
Microfluidic cell culture and its application in high-throughput drug screening: cardiotoxicity assay for hERG channels. J Biomol Screen. 2011 Jan;16(1):101-11
[PubMed ID: 21131594]
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Mohr JC Zhang J Azarin SM Soerens AG de Pablo JJ Thomson JA Lyons GE Palecek SP Kamp TJ .
The microwell control of embryoid body size in order to regulate cardiac differentiation of human embryonic stem cells. Biomaterials. 2010 Mar;31(7):1885-93
[PubMed ID: 19945747]
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Zhang J Wilson GF Soerens AG Koonce CH Yu J Palecek SP Thomson JA Kamp TJ .
Functional cardiomyocytes derived from human induced pluripotent stem cells. Circ Res. 2009 Feb 27;104(4):e30-41
[PubMed ID: 19213953]
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Raval AN Kamp TJ Hogle LF .
Cellular therapies for heart disease: unveiling the ethical and public policy challenges. J Mol Cell Cardiol. 2008 Oct;45(4):593-601
[PubMed ID: 18155721]
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Balijepalli RC Kamp TJ .
Caveolae, ion channels and cardiac arrhythmias. Prog Biophys Mol Biol. 2008 Oct-Nov;98(2-3):149-60
[PubMed ID: 19351512]
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Balijepalli RC Delisle BP Balijepalli SY Foell JD Slind JK Kamp TJ January CT .
Kv11.1 (ERG1) K+ channels localize in cholesterol and sphingolipid enriched membranes and are modulated by membrane cholesterol. Channels (Austin). 2007 Jul-Aug;1(4):263-72
[PubMed ID: 18708743]
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He JQ January CT Thomson JA Kamp TJ .
Human embryonic stem cell-derived cardiomyocytes: drug discovery and safety pharmacology. Expert Opin Drug Discov. 2007 May;2(5):739-53
[PubMed ID: 23488962]
