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Paul M. Sondel, MD, PhD
 


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Paul M. Sondel, MD, PhD Print Friendly Page

Faculty, University of Wisconsin School of Medicine and Public Health

Paul Sondel, M.D., Ph.D. is the Reed and Carolee Walker Professor in Pediatric Oncology at the University of Wisconsin – Madison. 
 
Dr. Sondel, a Milwaukee native, completed undergraduate and graduate education at UW-Madison leading to a Ph.D. in Genetics (1975), with guidance from Bone Marrow Transplant pioneer, Fritz Bach, M.D. He received his M.D. magna cum laude in 1977 from Harvard Medical School, while beginning his research in tumor immunology. Following pediatric residency training at the Universities of Minnesota and Wisconsin, he joined the faculty of UW-Madison in 1980 in the Departments of Pediatrics, Human Oncology and Genetics. He was promoted to professor in 1987, and became leader of the UW Carbone Cancer Center's Program in Immunology and Immunotherapy in 1990, when he also became Head of the Division of Pediatric Oncology.
 
Dr. Sondel has been a leader in scientific policy through multiple national committee roles, including The National Institutes of Health, The American Cancer Society, The Children's Oncology Group (COG), The National Cancer Institute, where he was a member of the Board of Scientific Counselors, and St. Jude's Children’s Research Hospital, where he was the Chair of their Scientific Advisory Committee and is now chair of their cancer center's external advisory board.
 
Clinically, he has worked with COG in contributing to the progress of the past 30 years in the development of curative treatments for childhood cancers. He is devoted to his own patients, and committed to leading a multidisciplinary team that is providing comprehensive and compassionate, state of the art treatment for all childhood cancer and hematology patients at the University of Wisconsin.

Specialties

Pediatric Hematology and Oncology

UW Health Clinics

American Family Children's Hospital
(608) 263-6420 | (800) 323-8942 | Map

Hospital Affiliation(s)

American Family Children's Hospital (primary)
UnityPoint Health - Meriter (secondary)

UW School of Medicine and Public Health

Department of Pediatrics

Professional Certifications and Education

Board Certification Pediatrics
Fellowship

Pediatric Oncology, Midwest Children's Cancer Center at Children's Hospital of Wisconsin, Milwaukee, WI


Residency University of Wisconsin Hospital and Clinics, Madison, WI
Internship University of Minnesota Affiliated Hospitals, Minneapolis, MN
Medical School Harvard Medical School, Boston, MA, 1977

Awards/Honors

Madison Magazine Top Docs 2016

Best Doctors® in America 2015

National Cancer Institute (NCI) Outstanding Investigator Award 2015

Newsweek's Top Cancer Doctors 2015

Best Doctors® in America 2014

Best Doctors® in America 2013


Medical interpreters are available to help patients communicate with hospital and clinic staff. For more information, please contact interpreter services at (608) 262-9000.

Procedures

Our doctors provide a wide range of services. The following list represents some, but not all, of the procedures offered by this physician.

Programs & Conditions

Research
Dr. Sondel's research has emphasized the translation of laboratory innovations into clinical progress. His laboratory has pursued the biology of graft-versus-leukemia reactions, activation of anti-tumor immune destruction with Interleukin-2 and the use of tumor reactive monoclonal antibodies to facilitate tumor killing by lymphocytes. These studies have all moved into clinical testing led by Dr. Sondel at UW, and in national studies he has led through the Children’s Oncology Group (COG).

He has published more than 360 scientific articles and chapters, and his laboratory has provided training for 58 graduate students and post-doctoral fellows.

Learn more about Dr. Sondel's research: UW-Madison Department of Genetics | Sondel Laboratory


PubMed Articles
Mody R Naranjo A Van Ryn C Yu AL London WB Shulkin BL Parisi MT Servaes SE Diccianni MB Sondel PM Bender JG Maris JM Park JR Bagatell R . Irinotecan-temozolomide with temsirolimus or dinutuximab in children with refractory or relapsed neuroblastoma (COG ANBL1221): an open-label, randomised, phase 2 trial. Lancet Oncol. 2017 Jul;18(7):946-957
[PubMed ID: 28549783]
Erbe AK Wang W Reville PK Carmichael L Kim K Mendonca EA Song Y Hank JA London WB Naranjo A Hong F Hogarty MD Maris JM Park JR Ozkaynak MF Miller JS Gilman AL Kahl B Yu AL Sondel PM . HLA-Bw4-I-80 Isoform Differentially Influences Clinical Outcome As Compared to HLA-Bw4-T-80 and HLA-A-Bw4 Isoforms in Rituximab or Dinutuximab-Based Cancer Immunotherapy. Front Immunol. 2017;8:675
[PubMed ID: 28659916]
Erbe AK Wang W Goldberg J Gallenberger M Kim K Carmichael L Hess D Mendonca EA Song Y Hank JA Cheng SC Signoretti S Atkins M Carlson A Mier JW Panka DJ McDermott DF Sondel PM . FCGR Polymorphisms Influence Response to IL2 in Metastatic Renal Cell Carcinoma. Clin Cancer Res. 2017 May 1;23(9):2159-2168
[PubMed ID: 27742794]
Wang W Erbe AK DeSantes KB Sondel PM . Donor selection for ex vivo-expanded natural killer cells as adoptive cancer immunotherapy. Future Oncol. 2017 May;13(12):1043-1047
[PubMed ID: 28492088]
Rakhmilevich AL Felder M Lever L Slowinski J Rasmussen K Hoefges A Van De Voort TJ Loibner H Korman AJ Gillies SD Sondel PM . Effective Combination of Innate and Adaptive Immunotherapeutic Approaches in a Mouse Melanoma Model. J Immunol. 2017 Feb 15;198(4):1575-1584
[PubMed ID: 28062694]
Wang W Erbe AK Gallenberger M Kim K Carmichael L Hess D Mendonca EA Song Y Hank JA Cheng SC Signoretti S Atkins M Carlson A Weiss JM Mier J Panka D McDermott DF Sondel PM . Killer immunoglobulin-like receptor (KIR) and KIR-ligand genotype do not correlate with clinical outcome of renal cell carcinoma patients receiving high-dose IL2. Cancer Immunol Immunother. 2016 Dec;65(12):1523-1532
[PubMed ID: 27695964]
Wang W Erbe AK Alderson KA Phillips E Gallenberger M Gan J Campana D Hank JA Sondel PM . Human NK cells maintain licensing status and are subject to killer immunoglobulin-like receptor (KIR) and KIR-ligand inhibition following ex vivo expansion. Cancer Immunol Immunother. 2016 Sep;65(9):1047-59
[PubMed ID: 27392940]
Perez Horta Z Goldberg JL Sondel PM . Anti-GD2 mAbs and next-generation mAb-based agents for cancer therapy. Immunotherapy. 2016 Sep;8(9):1097-117
[PubMed ID: 27485082]
Albertini MR Ranheim EA Zuleger CL Sondel PM Hank JA Bridges A Newton MA McFarland T Collins J Clements E Henry MB Neuman HB Weber S Whalen G Galili U . Phase I study to evaluate toxicity and feasibility of intratumoral injection of α-gal glycolipids in patients with advanced melanoma. Cancer Immunol Immunother. 2016 Aug;65(8):897-907
[PubMed ID: 27207605]
Morris ZS Guy EI Francis DM Gressett MM Werner LR Carmichael LL Yang RK Armstrong EA Huang S Navid F Gillies SD Korman A Hank JA Rakhmilevich AL Harari PM Sondel PM . In Situ Tumor Vaccination by Combining Local Radiation and Tumor-Specific Antibody or Immunocytokine Treatments. Cancer Res. 2016 Jul 1;76(13):3929-41
[PubMed ID: 27197149]
Neri D Sondel PM . Immunocytokines for cancer treatment: past, present and future. Curr Opin Immunol. 2016 Jun;40:96-102
[PubMed ID: 27060634]
Kohrt HE Tumeh PC Benson D Bhardwaj N Brody J Formenti S Fox BA Galon J June CH Kalos M Kirsch I Kleen T Kroemer G Lanier L Levy R Lyerly HK Maecker H Marabelle A Melenhorst J Miller J Melero I Odunsi K Palucka K Peoples G Ribas A Robins H Robinson W Serafini T Sondel P Vivier E Weber J Wolchok J Zitvogel L Disis ML Cheever MA . Immunodynamics: a cancer immunotherapy trials network review of immune monitoring in immuno-oncology clinical trials. J Immunother Cancer. 2016;4:15
[PubMed ID: 26981245]
Erbe AK Wang W Gallenberger M Hank JA Sondel PM . Genotyping Single Nucleotide Polymorphisms and Copy Number Variability of the FCGRs Expressed on NK Cells. Methods Mol Biol. 2016;1441:43-56
[PubMed ID: 27177655]
Jensen JL Rakhmilevich A Heninger E Broman AT Hope C Phan F Miyamoto S Maroulakou I Callander N Hematti P Chesi M Bergsagel PL Sondel P Asimakopoulos F . Tumoricidal Effects of Macrophage-Activating Immunotherapy in a Murine Model of Relapsed/Refractory Multiple Myeloma. Cancer Immunol Res. 2015 Aug;3(8):881-90
[PubMed ID: 25941352]
Shi Y Felder MA Sondel PM Rakhmilevich AL . Synergy of anti-CD40, CpG and MPL in activation of mouse macrophages. Mol Immunol. 2015 Aug;66(2):208-15
[PubMed ID: 25829245]
Goldberg JL Sondel PM . Enhancing Cancer Immunotherapy Via Activation of Innate Immunity. Semin Oncol. 2015 Aug;42(4):562-72
[PubMed ID: 26320061]
Wang W Erbe AK Hank JA Morris ZS Sondel PM . NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity in Cancer Immunotherapy. Front Immunol. 2015;6:368
[PubMed ID: 26284063]
McDowell KA Hank JA DeSantes KB Capitini CM Otto M Sondel PM . NK cell-based immunotherapies in Pediatric Oncology. J Pediatr Hematol Oncol. 2015 Mar;37(2):79-93
[PubMed ID: 25590232]
Sheridan RT Hudon J Hank JA Sondel PM Kiessling LL . Rhamnose glycoconjugates for the recruitment of endogenous anti-carbohydrate antibodies to tumor cells. Chembiochem. 2014 Jul 7;15(10):1393-8
[PubMed ID: 24909955]
Navid F Sondel PM Barfield R Shulkin BL Kaufman RA Allay JA Gan J Hutson P Seo S Kim K Goldberg J Hank JA Billups CA Wu J Furman WL McGregor LM Otto M Gillies SD Handgretinger R Santana VM . Phase I trial of a novel anti-GD2 monoclonal antibody, Hu14.18K322A, designed to decrease toxicity in children with refractory or recurrent neuroblastoma. J Clin Oncol. 2014 May 10;32(14):1445-52
[PubMed ID: 24711551]