Ozioma C. Okonkwo, PhD Print Friendly PageFaculty, University of Wisconsin School of Medicine and Public Health
Ozioma C. Okonkwo, PhD, is an Assistant Professor of Medicine at the University of Wisconsin School of Medicine and Public Health. He specializes in the neuropsychological evaluation of geriatric cognitive disorders, especially those due to suspected Alzheimer's disease.
UW Health Clinics
UW School of Medicine and Public Health
|Department of Medicine|
Professional Certifications and Education
Licensed Clinical Psychologist
NIH T32 AG027668, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD
VA Advanced Fellowship in Geriatrics, the Geriatric Research, Education, and Clinical Center (GRECC), William S. Middleton Memorial Veterans Hospital, Madison, WI
Warren Alpert Medical School of Brown University, Providence, RI
University of Alabama, Birmingham, AL, 2009
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Dr. Okonkwo's research focuses on clarifying how alterations in the brain and other biomolecules (such as cerebrospinal fluid β-amyloid) place some cognitively-normal individuals on a pernicious trajectory that culminates in probable Alzheimer's disease. In this context, Dr. Okonkwo is also interested in discovering new knowledge concerning the modulation of the link between brain changes and cognitive decline by both modifiable (e.g., cognitively stimulating activities, physical exercise) and non-modifiable (e.g., genetic vulnerability) factors.
Darst BF Koscik RL Racine AM Oh JM Krause RA Carlsson CM Zetterberg H Blennow K Christian BT Bendlin BB Okonkwo OC Hogan KJ Hermann BP Sager MA Asthana S Johnson SC Engelman CD .
Pathway-Specific Polygenic Risk Scores as Predictors of Amyloid-β Deposition and Cognitive Function in a Sample at Increased Risk for Alzheimer's Disease. J Alzheimers Dis. 2016 Sep 21;
[PubMed ID: 27662287]
Yang R Sabharwal V Okonkwo OS Shlykova N Tong R Lin LY Wang W Guo S Rosowski JJ Pelton SI Kohane DS .
Treatment of otitis media by transtympanic delivery of antibiotics. Sci Transl Med. 2016 Sep 14;8(356):356ra120
[PubMed ID: 27629487]
Racine AM Koscik RL Berman SE Nicholas CR Clark LR Okonkwo OC Rowley HA Asthana S Bendlin BB Blennow K Zetterberg H Gleason CE Carlsson CM Johnson SC .
Biomarker clusters are differentially associated with longitudinal cognitive decline in late midlife. Brain. 2016 Aug;139(Pt 8):2261-74
[PubMed ID: 27324877]
Clark LR Racine AM Koscik RL Okonkwo OC Engelman CD Carlsson CM Asthana S Bendlin BB Chappell R Nicholas CR Rowley HA Oh JM Hermann BP Sager MA Christian BT Johnson SC .
Beta-amyloid and cognitive decline in late middle age: Findings from the Wisconsin Registry for Alzheimer's Prevention study. Alzheimers Dement. 2016 Jul;12(7):805-14
[PubMed ID: 26806386]
Merluzzi AP Dean DC 3rd Adluru N Suryawanshi GS Okonkwo OC Oh JM Hermann BP Sager MA Asthana S Zhang H Johnson SC Alexander AL Bendlin BB .
Age-dependent differences in brain tissue microstructure assessed with neurite orientation dispersion and density imaging. Neurobiol Aging. 2016 Jul;43:79-88
[PubMed ID: 27255817]
Okoye O Okonkwo O Oderinlo O Hassan K Ijasan A .
Bilateral concomitant intravitreal anti-vascular endothelial growth factor injection: Experience in a Nigerian tertiary private eye care facility. Niger J Clin Pract. 2016 Jul-Aug;19(4):544-8
[PubMed ID: 27251975]
Clark LR Koscik RL Nicholas CR Okonkwo OC Engelman CD Bratzke LC Hogan KJ Mueller KD Bendlin BB Carlsson CM Asthana S Sager MA Hermann BP Johnson SC .
Mild Cognitive Impairment in Late Middle Age in the Wisconsin Registry for Alzheimer's Prevention Study: Prevalence and Characteristics Using Robust and Standard Neuropsychological Normative Data. Arch Clin Neuropsychol. 2016 May 8;
[PubMed ID: 27193363]
Dougherty R Boots E Schultz S Johnson S Okonkwo O Cook DB .
Influence Of VO2peak Criteria On Aging And Alzheimer's Research: 2932 June 3 1: 30 PM - 1: 45 PM. Med Sci Sports Exerc. 2016 May;48(5 Suppl 1):822
[PubMed ID: 27361501]
Abimbola S Molemodile SK Okonkwo OA Negin J Jan S Martiniuk AL .
'The government cannot do it all alone': realist analysis of the minutes of community health committee meetings in Nigeria. Health Policy Plan. 2016 Apr;31(3):332-45
[PubMed ID: 26210167]
Ly M Adluru N Destiche DJ Lu SY Oh JM Hoscheidt SM Alexander AL Okonkwo OC Rowley HA Sager MA Johnson SC Bendlin BB .
Fornix Microstructure and Memory Performance Is Associated with Altered Neural Connectivity during Episodic Recognition. J Int Neuropsychol Soc. 2016 Feb;22(2):191-204
[PubMed ID: 26888616]
Dougherty RJ Ellingson LD Schultz SA Boots EA Meyer JD Lindheimer JB Van Riper S Stegner AJ Edwards DF Oh JM Koscik RL Dowling MN Gallagher CL Carlsson CM Rowley HA Bendlin BB Asthana S Hermann BP Sager MA Johnson SC Okonkwo OC Cook DB .
Meeting physical activity recommendations may be protective against temporal lobe atrophy in older adults at risk for Alzheimer's disease. Alzheimers Dement (Amst). 2016;4:14-7
[PubMed ID: 27489874]
Racine AM Koscik RL Nicholas CR Clark LR Okonkwo OC Oh JM Hillmer AT Murali D Barnhart TE Betthauser TJ Gallagher CL Rowley HA Dowling NM Asthana S Bendlin BB Blennow K Zetterberg H Carlsson CM Christian BT Johnson SC .
Cerebrospinal fluid ratios with Aβ42 predict preclinical brain β-amyloid accumulation. Alzheimers Dement (Amst). 2016;2:27-38
[PubMed ID: 26955655]
Ithapu VK Singh V Okonkwo OC Chappell RJ Dowling NM Johnson SC .
Imaging-based enrichment criteria using deep learning algorithms for efficient clinical trials in mild cognitive impairment. Alzheimers Dement. 2015 Dec;11(12):1489-99
[PubMed ID: 26093156]
Gallagher CL Bell B Palotti M Oh J Christian BT Okonkwo O Sojkova J Buyan-Dent L Nickles RJ Harding SJ Stone CK Johnson SC Holden JE .
Anterior cingulate dopamine turnover and behavior change in Parkinson's disease. Brain Imaging Behav. 2015 Dec;9(4):821-7
[PubMed ID: 25511521]
Schultz SA Larson J Oh J Koscik R Dowling MN Gallagher CL Carlsson CM Rowley HA Bendlin BB Asthana S Hermann BP Johnson SC Sager M LaRue A Okonkwo OC .
Participation in cognitively-stimulating activities is associated with brain structure and cognitive function in preclinical Alzheimer's disease. Brain Imaging Behav. 2015 Dec;9(4):729-36
[PubMed ID: 25358750]
Nicholas CR Okonkwo OC Bendlin BB Oh JM Asthana S Rowley HA Hermann B Sager MA Johnson SC .
Posteromedial hyperactivation during episodic recognition among people with memory decline: findings from the WRAP study. Brain Imaging Behav. 2015 Dec;9(4):690-702
[PubMed ID: 25332108]
Kim WH Ravi SN Johnson SC Okonkwo OC Singh V .
On Statistical Analysis of Neuroimages with Imperfect Registration. Proc IEEE Int Conf Comput Vis. 2015 Dec;2015:666-674
[PubMed ID: 27042168]
Boots EA Schultz SA Almeida RP Oh JM Koscik RL Dowling MN Gallagher CL Carlsson CM Rowley HA Bendlin BB Asthana S Sager MA Hermann BP Johnson SC Okonkwo OC .
Occupational Complexity and Cognitive Reserve in a Middle-Aged Cohort at Risk for Alzheimer's Disease. Arch Clin Neuropsychol. 2015 Nov;30(7):634-42
[PubMed ID: 26156334]
Schultz SA Boots EA Almeida RP Oh JM Einerson J Korcarz CE Edwards DF Koscik RL Dowling MN Gallagher CL Bendlin BB Christian BT Zetterberg H Blennow K Carlsson CM Asthana S Hermann BP Sager MA Johnson SC Stein JH Okonkwo OC .
Cardiorespiratory Fitness Attenuates the Influence of Amyloid on Cognition. J Int Neuropsychol Soc. 2015 Nov;21(10):841-50
[PubMed ID: 26581795]
Boots EA Schultz SA Oh JM Larson J Edwards D Cook D Koscik RL Dowling MN Gallagher CL Carlsson CM Rowley HA Bendlin BB LaRue A Asthana S Hermann BP Sager MA Johnson SC Okonkwo OC .
Cardiorespiratory fitness is associated with brain structure, cognition, and mood in a middle-aged cohort at risk for Alzheimer's disease. Brain Imaging Behav. 2015 Sep;9(3):639-49
[PubMed ID: 25319359]