Michael J. MacDonald, MD Print Friendly PageFaculty, University of Wisconsin School of Medicine and Public Health
Michael J. MacDonald, MD, earned his medical degree from Washington University in St. Louis, Missouri, completed his residency at Massachusetts General Hospital, Boston, and completed fellowship training in pediatric endocrinology and diabetes at Harvard Medical School, Boston. Dr. MacDonald is certified by the American Board of Pediatrics in pediatric endocrinology and pediatrics. He has a special clinical interest in children with diabetes, especially atypical diabetes and the cause and genetics of the disease, hypoglycemia, and biochemistry of the pancreatic insulin-producing cells.
UW Health Clinics
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UW School of Medicine and Public Health
|Department of Pediatrics|
Professional Certifications and Education
Children's Hospital Medical Center, Boston, MA
Elliott P. Joslin Research Laboratory, Harvard Medical School, Boston, MA
Massachusetts General Hospital, Boston, MA
Women & Children's Hospital of Buffalo, Buffalo, NY
Washington University, St. Louis, MO, 1970
Madiraju AK Erion DM Rahimi Y Zhang XM Braddock DT Albright RA Prigaro BJ Wood JL Bhanot S MacDonald MJ Jurczak MJ Camporez JP Lee HY Cline GW Samuel VT Kibbey RG Shulman GI .
Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase. Nature. 2014 Jun 26;510(7506):542-6
[PubMed ID: 24847880]
Wutthisathapornchai A Vongpipatana T Muangsawat S Boonsaen T MacDonald MJ Jitrapakdee S .
Multiple E-boxes in the distal promoter of the rat pyruvate carboxylase gene function as a glucose-responsive element. PLoS One. 2014;9(7):e102730
[PubMed ID: 25054881]
MacDonald MJ Brown LJ Longacre MJ Stoker SW Kendrick MA Hasan NM .
Knockdown of both mitochondrial isocitrate dehydrogenase enzymes in pancreatic beta cells inhibits insulin secretion. Biochim Biophys Acta. 2013 Nov;1830(11):5104-11
[PubMed ID: 23876293]
MacDonald MJ Hasan NM Dobrzyn A Stoker SW Ntambi JM Liu X Sampath H .
Knockdown of pyruvate carboxylase or fatty acid synthase lowers numerous lipids and glucose-stimulated insulin release in insulinoma cells. Arch Biochem Biophys. 2013 Apr 1;532(1):23-31
[PubMed ID: 23357280]
Wolfgram PM Macdonald MJ .
Severe Hypertriglyceridemia Causing Acute Pancreatitis in a Child with New Onset Type I Diabetes Mellitus Presenting in Ketoacidosis. J Pediatr Intensive Care. 2013;2(2):77-80
[PubMed ID: 24455446]
Fahien LA Macdonald MJ .
The complex mechanism of glutamate dehydrogenase in insulin secretion. Diabetes. 2011 Oct;60(10):2450-4
[PubMed ID: 21948999]
MacDonald MJ Longacre MJ Stoker SW Kendrick M Thonpho A Brown LJ Hasan NM Jitrapakdee S Fukao T Hanson MS Fernandez LA Odorico J .
Differences between human and rodent pancreatic islets: low pyruvate carboxylase, atp citrate lyase, and pyruvate carboxylation and high glucose-stimulated acetoacetate in human pancreatic islets. J Biol Chem. 2011 May 27;286(21):18383-96
[PubMed ID: 21454710]
Hasan NM Longacre MJ Seed Ahmed M Kendrick MA Gu H Ostenson CG Fukao T MacDonald MJ .
Lower succinyl-CoA:3-ketoacid-CoA transferase (SCOT) and ATP citrate lyase in pancreatic islets of a rat model of type 2 diabetes: knockdown of SCOT inhibits insulin release in rat insulinoma cells. Arch Biochem Biophys. 2010 Jul;499(1-2):62-8
[PubMed ID: 20460097]
Hasan NM Kendrick MA Druckenbrod NR Huelsmeyer MK Warner TF MacDonald MJ .
Genetic association of the neuropilin-1 gene with type 1 diabetes in children: Neuropilin-1 expression in pancreatic islets. Diabetes Res Clin Pract. 2010 Mar;87(3):e29-32
[PubMed ID: 20053475]
Brown LJ Longacre MJ Hasan NM Kendrick MA Stoker SW Macdonald MJ .
Chronic reduction of the cytosolic or mitochondrial NAD(P)-malic enzyme does not affect insulin secretion in a rat insulinoma cell line. J Biol Chem. 2009 Dec 18;284(51):35359-67
[PubMed ID: 19858194]
MacDonald MJ Longacre MJ Kendrick MA .
Mitochondrial malic enzyme (ME2) in pancreatic islets of the human, rat and mouse and clonal insulinoma cells. Arch Biochem Biophys. 2009 Aug 15;488(2):100-4
[PubMed ID: 19691144]
Hasan NM Longacre MJ Stoker SW Boonsaen T Jitrapakdee S Kendrick MA Wallace JC MacDonald MJ .
Impaired anaplerosis and insulin secretion in insulinoma cells caused by small interfering RNA-mediated suppression of pyruvate carboxylase. J Biol Chem. 2008 Oct 17;283(42):28048-59
[PubMed ID: 18697738]
Fallon MJ MacDonald MJ .
Beta-cell alpha-ketoglutarate hydroxylases may acutely participate in insulin secretion. Metabolism. 2008 Aug;57(8):1148-54
[PubMed ID: 18640395]
Macdonald MJ Hasan NM Longacre MJ .
Studies with leucine, beta-hydroxybutyrate and ATP citrate lyase-deficient beta cells support the acetoacetate pathway of insulin secretion. Biochim Biophys Acta. 2008 Jul-Aug;1780(7-8):966-72
[PubMed ID: 18439432]
MacDonald MJ Stoker SW Hasan NM .
Anaplerosis from glucose, alpha-ketoisocaproate, and pyruvate in pancreatic islets, INS-1 cells and liver mitochondria. Mol Cell Biochem. 2008 Jun;313(1-2):195-202
[PubMed ID: 18414997]
McVean JJ Eickhoff JC MacDonald MJ .
Prevalence of early microalbuminuria in children with type 1 diabetes mellitus. J Pediatr Endocrinol Metab. 2008 May;21(5):469-71
[PubMed ID: 18655529]
MacDonald MJ Dobrzyn A Ntambi J Stoker SW .
The role of rapid lipogenesis in insulin secretion: Insulin secretagogues acutely alter lipid composition of INS-1 832/13 cells. Arch Biochem Biophys. 2008 Feb 15;470(2):153-62
[PubMed ID: 18082128]
MacDonald MJ Longacre MJ Stoker SW Brown LJ Hasan NM Kendrick MA .
Acetoacetate and beta-hydroxybutyrate in combination with other metabolites release insulin from INS-1 cells and provide clues about pathways in insulin secretion. Am J Physiol Cell Physiol. 2008 Feb;294(2):C442-50
[PubMed ID: 18160486]
MacDonald MJ Smith AD 3rd Hasan NM Sabat G Fahien LA .
Feasibility of pathways for transfer of acyl groups from mitochondria to the cytosol to form short chain acyl-CoAs in the pancreatic beta cell. J Biol Chem. 2007 Oct 19;282(42):30596-606
[PubMed ID: 17724028]
McVean JJ Eickhoff JC MacDonald MJ .
Factors correlating with improved A1C in children using continuous subcutaneous insulin infusion. Diabetes Care. 2007 Oct;30(10):2499-500
[PubMed ID: 17586738]