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UW Health SMPH
American Family Children's Hospital
Matthew W. Squire, MD, MS close
Matthew W. Squire, MD, MS

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Matthew W. Squire, MD, MS Print Friendly Page

Faculty, University of Wisconsin School of Medicine and Public Health

Dr. Squire is Fellowship trained in adult reconstruction. He specializes in routine and complex hip and knee replacement, hip resurfacing, robotic partial knee replacement and routine and complex revision hip and knee replacement.


Orthopedics and Rehabilitation

UW Health Clinics

UW Health at The American Center
(608) 263-7540 | (844) 607-4800 | Map

Hospital Affiliation(s)

University of Wisconsin Hospital and Clinics (primary)
Veterans Hospital - Wm. S. Middleton Memorial (secondary)

UW School of Medicine and Public Health

Department of Orthopedics and Rehabilitation

Professional Certifications and Education

Board Certification Orthopedic Surgery
Fellowship Charlotte Orthopedic Specialists, NC
Residency University of Wisconsin Hospital and Clinics, Madison, WI
Medical School University of Iowa, Iowa City, IA, 1998

Medical interpreters are available to help patients communicate with hospital and clinic staff. For more information, please contact interpreter services at (608) 262-9000.


Our doctors provide a wide range of services. The following list represents some, but not all, of the procedures offered by this physician.

Programs & Conditions

  • Knee Pain

Dr. Squire’s research interests include prevention and treatment of orthopedic infection, hip resurfacing, robotic hip and knee surgery, design of hip and knee replacement devices, avascular necrosis, cartilage regeneration and non-destructive implant removal.

PubMed Articles
Tsai TL Wang B Squire MW Guo LW Li WJ . Endothelial cells direct human mesenchymal stem cells for osteo- and chondro-lineage differentiation through endothelin-1 and AKT signaling. Stem Cell Res Ther. 2015 May 1;6:88
[PubMed ID: 25998005]
Slane J Vivanco J Rose W Ploeg HL Squire M . Mechanical, material, and antimicrobial properties of acrylic bone cement impregnated with silver nanoparticles. Mater Sci Eng C Mater Biol Appl. 2015 Mar;48:188-96
[PubMed ID: 25579913]
Brown PT Squire MW Li WJ . Characterization and evaluation of mesenchymal stem cells derived from human embryonic stem cells and bone marrow. Cell Tissue Res. 2014 Oct;358(1):149-64
[PubMed ID: 24927918]
Slane J Vivanco J Ebenstein D Squire M Ploeg HL . Multiscale characterization of acrylic bone cement modified with functionalized mesoporous silica nanoparticles. J Mech Behav Biomed Mater. 2014 Sep;37:141-52
[PubMed ID: 24911668]
Slane JA Vivanco JF Rose WE Squire MW Ploeg HL . The influence of low concentrations of a water soluble poragen on the material properties, antibiotic release, and biofilm inhibition of an acrylic bone cement. Mater Sci Eng C Mater Biol Appl. 2014 Sep;42:168-76
[PubMed ID: 25063107]
Slane J Vivanco J Meyer J Ploeg HL Squire M . Modification of acrylic bone cement with mesoporous silica nanoparticles: effects on mechanical, fatigue and absorption properties. J Mech Behav Biomed Mater. 2014 Jan;29:451-61
[PubMed ID: 24211354]
Squire MW . Technologically enhanced total knee replacement: is the juice worth the squeeze? AJR Am J Roentgenol. 2013 Sep;201(3):W451-2
[PubMed ID: 23971476]
Sheehy AM Benca J Glinberg SL Li Z Nautiyal A Anderson PA Squire MW Coursin DB . Preoperative "NPO" as an opportunity for diabetes screening. J Hosp Med. 2012 Oct;7(8):611-6
[PubMed ID: 22887757]
Squire MW . Imaging of metal-on-metal hip prostheses. AJR Am J Roentgenol. 2011 Sep;197(3):556-7
[PubMed ID: 21862796]
Squire MW Della Valle CJ Parvizi J . Preoperative diagnosis of periprosthetic joint infection: role of aspiration. AJR Am J Roentgenol. 2011 Apr;196(4):875-9
[PubMed ID: 21427339]
Burgers T Mason J Squire M Ploeg HL . Time-dependent fixation and implantation forces for a femoral knee component--an in vitro study. Med Eng Phys. 2010 Nov;32(9):968-73
[PubMed ID: 20674458]
Illgen RL 2nd Heiner JP Squire MW Conrad DN . Large-head metal-on-metal total hip arthroplasty using the Durom acetabular component at minimum 1-year interval. J Arthroplasty. 2010 Sep;25(6 Suppl):26-30
[PubMed ID: 20570096]
Squire MW Ludwig BJ Thompson JR Jagodzinski J Hall D Andes D . Premixed antibiotic bone cement: an in vitro comparison of antimicrobial efficacy. J Arthroplasty. 2008 Sep;23(6 Suppl 1):110-4
[PubMed ID: 18617361]
Squire M Griffin WL Mason JB Peindl RD Odum S . Acetabular component deformation with press-fit fixation. J Arthroplasty. 2006 Sep;21(6 Suppl 2):72-7
[PubMed ID: 16950065]
Squire M Fehring TK Odum S Griffin WL Bohannon Mason J . Failure of femoral surface replacement for femoral head avascular necrosis. J Arthroplasty. 2005 Oct;20(7 Suppl 3):108-14
[PubMed ID: 16214011]