Mark A. Sager, MD Print Friendly PageFaculty, University of Wisconsin School of Medicine and Public Health
Mark A. Sager, MD, is a Professor in the Department of Medicine at the University of Wisconsin-Madison School of Medicine and Public Health. He is the Director of the Wisconsin Alzheimer's Institute (WAI) and is the Principal Investigator of the Wisconsin Registry for Alzheimer's Prevention (WRAP), a longitudinal cohort study of adult children of persons with Alzheimer's disease who have volunteered for research designed to identify pre-clinical markers of the disease. Dr. Sager is also the Associate Director of the recently funded Wisconsin Alzheimer's Disease Research Center (ADRC) and leads the Education Core, which studies the early identification and management of persons with dementia.
UW Health Clinics
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UW School of Medicine and Public Health
|Department of Medicine|
Professional Certifications and Education
University of Wisconsin Hospital and Clinics, Madison, WI
University of Minnesota Medical Center
University of Minnesota Medical Center
University of Michigan Medical School, Ann Arbor, MI, 1972
Programs & Conditions
Johnson SC Christian BT Okonkwo OC Oh JM Harding S Xu G Hillmer AT Wooten DW Murali D Barnhart TE Hall LT Racine AM Klunk WE Mathis CA Bendlin BB Gallagher CL Carlsson CM Rowley HA Hermann BP Dowling NM Asthana S Sager MA .
Amyloid burden and neural function in people at risk for Alzheimer's Disease. Neurobiol Aging. 2013 Oct 23;
[PubMed ID: 24269021]
Birdsill AC Koscik RL Jonaitis EM Johnson SC Okonkwo OC Hermann BP Larue A Sager MA Bendlin BB .
Regional white matter hyperintensities: aging, Alzheimer's disease risk, and cognitive function. Neurobiol Aging. 2013 Oct 10;
[PubMed ID: 24199958]
Zuelsdorff ML Engelman CD Friedman EM Koscik RL Jonaitis EM Rue AL Sager MA .
Stressful events, social support, and cognitive function in middle-aged adults with a family history of Alzheimer's disease. J Aging Health. 2013 Sep;25(6):944-59
[PubMed ID: 23945762]
Ly M Canu E Xu G Oh J McLaren DG Dowling NM Alexander AL Sager MA Johnson SC Bendlin BB .
Midlife measurements of white matter microstructure predict subsequent regional white matter atrophy in healthy adults. Hum Brain Mapp. 2013 Jul 17;
[PubMed ID: 23861348]
Birdsill AC Carlsson CM Willette AA Okonkwo OC Johnson SC Xu G Oh JM Gallagher CL Koscik RL Jonaitis EM Hermann BP LaRue A Rowley HA Asthana S Sager MA Bendlin BB .
Low cerebral blood flow is associated with lower memory function in metabolic syndrome. Obesity (Silver Spring). 2013 Jul;21(7):1313-20
[PubMed ID: 23687103]
Willette AA Xu G Johnson SC Birdsill AC Jonaitis EM Sager MA Hermann BP La Rue A Asthana S Bendlin BB .
Insulin resistance, brain atrophy, and cognitive performance in late middle-aged adults. Diabetes Care. 2013 Feb;36(2):443-9
[PubMed ID: 23069842]
Engelman CD Koscik RL Jonaitis EM Okonkwo OC Hermann BP La Rue A Sager MA .
Interaction between two cholesterol metabolism genes influences memory: findings from the Wisconsin Registry for Alzheimer's Prevention. J Alzheimers Dis. 2013 Jan 1;36(4):749-57
[PubMed ID: 23669301]
Okonkwo OC Xu G Oh JM Dowling NM Carlsson CM Gallagher CL Birdsill AC Palotti M Wharton W Hermann BP Larue A Bendlin BB Rowley HA Asthana S Sager MA Johnson SC .
Cerebral Blood Flow is Diminished in Asymptomatic Middle-Aged Adults with Maternal History of Alzheimer's Disease. Cereb Cortex. 2012 Dec 12;
[PubMed ID: 23236200]
Carlsson CM Xu G Wen Z Barnet JH Blazel HM Chappell RJ Stein JH Asthana S Sager MA Alsop DC Rowley HA Fain SB Johnson SC .
Effects of atorvastatin on cerebral blood flow in middle-aged adults at risk for Alzheimer's disease: a pilot study. Curr Alzheimer Res. 2012 Oct;9(8):990-7
[PubMed ID: 22175654]
Chang TS Coen MH La Rue A Jonaitis E Koscik RL Hermann B Sager MA .
Machine learning amplifies the effect of parental family history of Alzheimer's disease on list learning strategy. J Int Neuropsychol Soc. 2012 May;18(3):428-39
[PubMed ID: 22321601]
Ries ML McLaren DG Bendlin BB Guofanxu Rowley HA Birn R Kastman EK Sager MA Asthana S Johnson SC .
Medial prefrontal functional connectivity--relation to memory self-appraisal accuracy in older adults with and without memory disorders. Neuropsychologia. 2012 Apr;50(5):603-11
[PubMed ID: 22230228]
Wharton W Stein JH Korcarz C Sachs J Olson SR Zetterberg H Dowling M Ye S Gleason CE Underbakke G Jacobson LE Johnson SC Sager MA Asthana S Carlsson CM .
The effects of ramipril in individuals at risk for Alzheimer's disease: results of a pilot clinical trial. J Alzheimers Dis. 2012;32(1):147-56
[PubMed ID: 22776970]
Bendlin BB Carlsson CM Johnson SC Zetterberg H Blennow K Willette AA Okonkwo OC Sodhi A Ries ML Birdsill AC Alexander AL Rowley HA Puglielli L Asthana S Sager MA .
CSF T-Tau/Aβ42 predicts white matter microstructure in healthy adults at risk for Alzheimer's disease. PLoS One. 2012;7(6):e37720
[PubMed ID: 22701578]
Johnson SC La Rue A Hermann BP Xu G Koscik RL Jonaitis EM Bendlin BB Hogan KJ Roses AD Saunders AM Lutz MW Asthana S Green RC Sager MA .
The effect of TOMM40 poly-T length on gray matter volume and cognition in middle-aged persons with APOE ε3/ε3 genotype. Alzheimers Dement. 2011 Jul;7(4):456-65
[PubMed ID: 21784354]
Dowling NM Hermann B La Rue A Sager MA .
Latent structure and factorial invariance of a neuropsychological test battery for the study of preclinical Alzheimer's disease. Neuropsychology. 2010 Nov;24(6):742-56
[PubMed ID: 21038965]
Bendlin BB Ries ML Canu E Sodhi A Lazar M Alexander AL Carlsson CM Sager MA Asthana S Johnson SC .
White matter is altered with parental family history of Alzheimer's disease. Alzheimers Dement. 2010 Sep;6(5):394-403
[PubMed ID: 20713315]
Bendlin BB Newman LM Ries ML Puglielli L Carlsson CM Sager MA Rowley HA Gallagher CL Willette AA Alexander AL Asthana S Johnson SC .
NSAIDs may protect against age-related brain atrophy. Front Aging Neurosci. 2010;2
[PubMed ID: 20877426]
Ward MA Bendlin BB McLaren DG Hess TM Gallagher CL Kastman EK Rowley HA Asthana S Carlsson CM Sager MA Johnson SC .
Low HDL Cholesterol is Associated with Lower Gray Matter Volume in Cognitively Healthy Adults. Front Aging Neurosci. 2010;2
[PubMed ID: 20725527]
Weimer DL Sager MA .
Early identification and treatment of Alzheimer's disease: social and fiscal outcomes. Alzheimers Dement. 2009 May;5(3):215-26
[PubMed ID: 19362885]
Xu G McLaren DG Ries ML Fitzgerald ME Bendlin BB Rowley HA Sager MA Atwood C Asthana S Johnson SC .
The influence of parental history of Alzheimer's disease and apolipoprotein E epsilon4 on the BOLD signal during recognition memory. Brain. 2009 Feb;132(Pt 2):383-91
[PubMed ID: 18829694]