Mario Otto, MD, PhD Print Friendly Page
Faculty, University of Wisconsin School of Medicine and Public HealthSpecialties
Pediatric Hematology and Oncology
UW Health Clinics
American Family Children's Hospital
(608) 263-6420
| (800) 323-8942
| Map
Hospital Affiliation(s)
American Family Children's Hospital (primary)
Meriter Hospital, St. Mary's Hospital (secondary)
Languages Spoken
| English, German |
| Medical interpreters are available to help patients communicate with hospital and clinic staff. For more information, please contact interpreter services at (608) 262-9000. |
UW School of Medicine and Public Health
| Department of Pediatrics |
Professional Certifications and Education
| Board Certification |
Pediatrics
|
| Fellowship |
St. Jude Children's Research Hospital, Memphis, TN
|
| Residency |
Children's University Hospital, Tuebingen, Germany
Akron Children's Hospital, Akron, OH |
| Internship |
Children's University Hospital, Tuebingen, Germany
|
| Medical School |
University of Tuebingen School of Medicine, Germany, 1995
|
Procedures
Our doctors provide a wide range of services. The following list represents some, but not all, of the procedures offered by this physician.
Programs & Conditions
- Acute Lymphoblastic Leukemia
- Acute Myeloid Leukemia
- Adrenocortical carcinoma
- Aplastic Anemia
- Astrocytoma
- Ataxia-telengiectasia
- Atypical Teratoid/Rhabdoid tumor
- Bleeding Disorders
- Brain Stem Glioma
- Chronic Myeloid Leukemia
- Congenital Hemolytic Anemias
- Craniopharyngioma
- Cyclic Neutropenia
- Diamond-Blackfan Syndrome
- Endocrine Tumors
- Ependymoma
- Ewing Sarcoma
- Fanconi's Anemia
- Germ Cell Tumors
- Hemophagocytic Lymphohistiocytosis
- Hemophilia A
- Hemophilia B
- Hepatoblastoma
- Hereditary Spherocytosis
- Hodgkin's Disease
- Immune Thrombocytopenc Purpura
- Juvenile Myelomonocytic Leukemia
- Kostmann Syndrome
- Langerhans' Cell Histiocytosis
- Medulloblastoma
- Myelodysplastic Syndromes
- Neuroblastoma
- Neurocutaneous Syndrome
- Neurofibromatosis
- Non-Hodgkin Lymphomas
- Optic Glioma
- Osteosarcoma
- Paroxysmal Nocturnal Hemoglobinuria
- Pediatric Cancer
- Pediatric Sickle Cell Disease
- Retinoblastoma
- Rhabdomyosarcoma
- Schwanomatosis
- Shwachman-Diamond Syndrome
- Sturge-Weber Syndrome
- Thalassemia Syndromes
- Thrombophilia
- Thyroid Tumors
- Tuberous Sclerosis
- Vascular malformations
- Von Willebrand Disease
- VonHippel-Lindau Disease
- Wilms Tumor
| Research |
Dr. Otto is pursuing novel, alternative approaches to treat childhood cancer. His research includes areas such as adoptive immunotherapies, nano-oncology and stem cell graft design for the transplant setting. |
PubMed Articles
-
Baiu DC Brazel CS Bao Y Otto M .
Interactions of Iron Oxide Nanoparticles with the Immune System: Challenges and Opportunities for their use in Nano-oncology. Curr Pharm Des. 2013 Apr 23;
[PubMed ID: 23621531]
-
Otto M Shulkin BL Kundu M Sandlund JT Snyder SE Metzger ML .
Histiocyte-rich xanthomatous pseudotumor mimicking relapse on positron emission tomography imaging in an adolescent with primary mediastinal diffuse large B-cell lymphoma. J Pediatr Hematol Oncol. 2012 Apr;34(3):232-5
[PubMed ID: 22082744]
-
Jiao P Zhou H Otto M Mu Q Li L Su G Zhang Y Butch ER Snyder SE Jiang G Yan B .
Leading neuroblastoma cells to die by multiple premeditated attacks from a multifunctionalized nanoconstruct. J Am Chem Soc. 2011 Sep 7;133(35):13918-21
[PubMed ID: 21827210]
-
Sorkin LS Otto M Baldwin WM 3rd Vail E Gillies SD Handgretinger R Barfield RC Ming Yu H Yu AL .
Anti-GD(2) with an FC point mutation reduces complement fixation and decreases antibody-induced allodynia. Pain. 2010 Apr;149(1):135-42
[PubMed ID: 20171010]
-
Barfield R Chen X Otto M Handgretinger R .
Beyond the FACS. Stem Cells. 2007 Nov;25(11):2972
[PubMed ID: 17656640]
-
Otto M Chen X Martin WJ Leung W Knowles J Holladay M Houston J Handgretinger R Barfield RC .
Selection of stem cells by using antibodies that target different CD34 epitopes yields different patterns of T-cell differentiation. Stem Cells. 2007 Feb;25(2):537-42
[PubMed ID: 17023516]
-
Otto M Barfield RC Martin WJ Iyengar R Leung W Leimig T Chaleff S Gillies SD Handgretinger R .
Combination immunotherapy with clinical-scale enriched human gammadelta T cells, hu14.18 antibody, and the immunocytokine Fc-IL7 in disseminated neuroblastoma. Clin Cancer Res. 2005 Dec 1;11(23):8486-91
[PubMed ID: 16322312]
-
Chen X Barfield R Benaim E Leung W Knowles J Lawrence D Otto M Shurtleff SA Neale GA Behm FG Turner V Handgretinger R .
Prediction of T-cell reconstitution by assessment of T-cell receptor excision circle before allogeneic hematopoietic stem cell transplantation in pediatric patients. Blood. 2005 Jan 15;105(2):886-93
[PubMed ID: 15358630]
-
Otto M Barfield RC Iyengar R Gatewood J Müller I Holladay MS Houston J Leung W Handgretinger R .
Human gammadelta T cells from G-CSF-mobilized donors retain strong tumoricidal activity and produce immunomodulatory cytokines after clinical-scale isolation. J Immunother. 2005 Jan-Feb;28(1):73-8
[PubMed ID: 15614047]
