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Loren C. Denlinger, MD, PhD close
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Loren C. Denlinger, MD, PhD
 

Loren C. Denlinger, MD, PhD Print Friendly Page

Faculty, University of Wisconsin School of Medicine and Public Health

Loren C. Denlinger, PhD, MD, earned his medical degree from the University of Wisconsin - Madison and completed his residency at UW Hospital and Clinics.

Specialties

Pulmonary and Critical Care Medicine

UW Health Clinics

UW Hospital and Clinics
(608) 263-7203 | (800) 323-8942 | Map
UW Hospital and Clinics
(608) 263-8954 | (800) 323-8942 | Map

Hospital Affiliation(s)

University of Wisconsin Hospital and Clinics (primary)

Languages Spoken

English
Medical interpreters are available to help patients communicate with hospital and clinic staff. For more information, please contact interpreter services at (608) 262-9000.

UW School of Medicine and Public Health

Department of Medicine

Professional Certifications and Education

Board Certification Internal Medicine
Pulmonary Disease
Fellowship University of Wisconsin Hospital and Clinics, Madison, WI
Residency University of Wisconsin Hospital and Clinics, Madison, WI
Internship University of Wisconsin Hospital and Clinics, Madison, WI
Medical School University of Wisconsin - Madison, 1998

Procedures

Our doctors provide a wide range of services. The following list represents some, but not all, of the procedures offered by this physician.

PubMed Articles
Castro M King TS Kunselman SJ Cabana MD Denlinger L Holguin F Kazani SD Moore WC Moy J Sorkness CA Avila P Bacharier LB Bleecker E Boushey HA Chmiel J Fitzpatrick AM Gentile D Hundal M Israel E Kraft M Krishnan JA LaForce C Lazarus SC Lemanske R Lugogo N Martin RJ Mauger DT Naureckas E Peters SP Phipatanakul W Que LG Sheshadri A Smith L Solway J Sullivan-Vedder L Sumino K Wechsler ME Wenzel S White SR Sutherland ER . Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial. JAMA. 2014 May;311(20):2083-91
[PubMed ID: 24838406]
Karta MR Wickert LE Curran CS Gavala ML Denlinger LC Gern JE Bertics PJ . Allergen challenge in vivo alters rhinovirus-induced chemokine secretion from human airway macrophages. J Allergy Clin Immunol. 2014 Apr;133(4):1227-30
[PubMed ID: 24529411]
Esnault S Kelly EA Johansson MW Liu LY Han ST Akhtar M Sandbo N Mosher DF Denlinger LC Mathur SK Malter JS Jarjour NN . Semaphorin 7A is expressed on airway eosinophils and upregulated by IL-5 family cytokines. Clin Immunol. 2014 Jan;150(1):90-100
[PubMed ID: 24333536]
Burnham ME Koziol-White CJ Esnault S Bates ME Evans MD Bertics PJ Denlinger LC . Human airway eosinophils exhibit preferential reduction in STAT signaling capacity and increased CISH expression. J Immunol. 2013 Sep 15;191(6):2900-6
[PubMed ID: 23956426]
Johansson MW Kruger SJ Schiebler ML Evans MD Sorkness RL Denlinger LC Busse WW Jarjour NN Montgomery RR Mosher DF Fain SB . Markers of vascular perturbation correlate with airway structural change in asthma. Am J Respir Crit Care Med. 2013 Jul 15;188(2):167-78
[PubMed ID: 23855693]
Esnault S Kelly EA Schwantes EA Liu LY DeLain LP Hauer JA Bochkov YA Denlinger LC Malter JS Mathur SK Jarjour NN . Identification of genes expressed by human airway eosinophils after an in vivo allergen challenge. PLoS One. 2013;8(7):e67560
[PubMed ID: 23844029]
Wickert LE Blanchette JB Waldschmidt NV Bertics PJ Denu JM Denlinger LC Lenertz LY . The C-terminus of human nucleotide receptor P2X7 is critical for receptor oligomerization and N-linked glycosylation. PLoS One. 2013;8(5):e63789
[PubMed ID: 23691096]
Denlinger LC Manthei DM Seibold MA Ahn K Bleecker E Boushey HA Calhoun WJ Castro M Chinchili VM Fahy JV Hawkins GA Icitovic N Israel E Jarjour NN King T Kraft M Lazarus SC Lehman E Martin RJ Meyers DA Peters SP Sheerar D Shi L Sutherland ER Szefler SJ Wechsler ME Sorkness CA Lemanske RF Jr . P2X7-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapy. Am J Respir Crit Care Med. 2013 Jan 1;187(1):28-33
[PubMed ID: 23144325]
Denlinger LC Kelly EA Dodge AM McCartney JG Meyer KC Cornwell RD Jackson MJ Evans MD Jarjour NN . Safety of and cellular response to segmental bronchoprovocation in allergic asthma. PLoS One. 2013;8(1):e51963
[PubMed ID: 23341886]
Shi L Manthei DM Guadarrama AG Lenertz LY Denlinger LC . Rhinovirus-induced IL-1β release from bronchial epithelial cells is independent of functional P2X7. Am J Respir Cell Mol Biol. 2012 Sep;47(3):363-71
[PubMed ID: 22493010]
Manthei DM Jackson DJ Evans MD Gangnon RE Tisler CJ Gern JE Lemanske RF Jr Denlinger LC . Protection from asthma in a high-risk birth cohort by attenuated P2X(7) function. J Allergy Clin Immunol. 2012 Aug;130(2):496-502
[PubMed ID: 22743305]
Denlinger LC Sorkness RL Lee WM Evans MD Wolff MJ Mathur SK Crisafi GM Gaworski KL Pappas TE Vrtis RF Kelly EA Gern JE Jarjour NN . Lower airway rhinovirus burden and the seasonal risk of asthma exacerbation. Am J Respir Crit Care Med. 2011 Nov 1;184(9):1007-14
[PubMed ID: 21816938]
Guilbert TW Denlinger LC . Role of infection in the development and exacerbation of asthma. Expert Rev Respir Med. 2010 Feb;4(1):71-83
[PubMed ID: 20305826]
Maenner MJ Denlinger LC Langton A Meyers KJ Engelman CD Skinner HG . Detecting gene-by-smoking interactions in a genome-wide association study of early-onset coronary heart disease using random forests. BMC Proc. 2009 Dec 15;3 Suppl 7:S88
[PubMed ID: 20018084]
Denlinger LC Shi L Guadarrama A Schell K Green D Morrin A Hogan K Sorkness RL Busse WW Gern JE . Attenuated P2X7 pore function as a risk factor for virus-induced loss of asthma control. Am J Respir Crit Care Med. 2009 Feb 15;179(4):265-70
[PubMed ID: 19201928]
Denlinger LC Coursin DB Schell K Angelini G Green DN Guadarrama AG Halsey J Prabhu U Hogan KJ Bertics PJ . Human P2X7 pore function predicts allele linkage disequilibrium. Clin Chem. 2006 Jun;52(6):995-1004
[PubMed ID: 16613995]
Denlinger LC Angelini G Schell K Green DN Guadarrama AG Prabhu U Coursin DB Bertics PJ Hogan K . Detection of human P2X7 nucleotide receptor polymorphisms by a novel monocyte pore assay predictive of alterations in lipopolysaccharide-induced cytokine production. J Immunol. 2005 Apr 1;174(7):4424-31
[PubMed ID: 15778408]
Denlinger LC Schell K Angelini G Green D Guadarrama A Prabhu U Coursin DB Hogan K Bertics PJ . A novel assay to detect nucleotide receptor P2X7 genetic polymorphisms influencing numerous innate immune functions. J Endotoxin Res. 2004;10(2):137-42
[PubMed ID: 15120006]
Denlinger LC Sommer JA Parker K Gudipaty L Fisette PL Watters JW Proctor RA Dubyak GR Bertics PJ . Mutation of a dibasic amino acid motif within the C terminus of the P2X7 nucleotide receptor results in trafficking defects and impaired function. J Immunol. 2003 Aug 1;171(3):1304-11
[PubMed ID: 12874219]
Guerra AN Fisette PL Pfeiffer ZA Quinchia-Rios BH Prabhu U Aga M Denlinger LC Guadarrama AG Abozeid S Sommer JA Proctor RA Bertics PJ . Purinergic receptor regulation of LPS-induced signaling and pathophysiology. J Endotoxin Res. 2003;9(4):256-63
[PubMed ID: 12935357]