American Family Children's Hospital
Loren C. Denlinger, MD, PhD close
Loren C. Denlinger, MD, PhD

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Loren C. Denlinger, MD, PhD Print Friendly Page

Faculty, University of Wisconsin School of Medicine and Public Health

Loren C. Denlinger, PhD, MD, earned his medical degree from the University of Wisconsin School of Medicine and Public Health (formerly UW Medical School), Madison, WI and completed his residency at UW Hospital and Clinics.


Pulmonary and Critical Care Medicine

UW Health Clinics

University Hospital
(608) 263-7203 | (800) 323-8942 | Map
University Hospital
(608) 263-8954 | (800) 323-8942 | Map

Hospital Affiliation(s)

University Hospital (primary)
Veterans Hospital - Wm. S. Middleton Memorial (secondary)

UW School of Medicine and Public Health

Department of Medicine

Professional Certifications and Education

Board Certification Critical Care Medicine
Pulmonary Disease
Fellowship University of Wisconsin Hospital and Clinics, Madison, WI
Residency University of Wisconsin Hospital and Clinics, Madison, WI
Internship University of Wisconsin Hospital and Clinics, Madison, WI
Medical School University of Wisconsin School of Medicine and Public Health (formerly UW Medical School), Madison, WI, 1998

Medical interpreters are available to help patients communicate with hospital and clinic staff. For more information, please contact interpreter services at (608) 262-9000.


Our doctors provide a wide range of services. The following list represents some, but not all, of the procedures offered by this physician.

Programs & Conditions

PubMed Articles
Ricklefs I Barkas I Duvall MG Cernadas M Grossman NL Israel E Bleecker ER Castro M Erzurum SC Fahy JV Gaston BM Denlinger LC Mauger DT Wenzel SE Comhair SA Coverstone AM Fajt ML Hastie AT Johansson MW Peters MC Phillips BR Levy BD . ALX receptor ligands define a biochemical endotype for severe asthma. JCI Insight. 2017 Jul 20;2(14)
[PubMed ID: 28724795]
Durack J Lynch SV Nariya S Bhakta NR Beigelman A Castro M Dyer AM Israel E Kraft M Martin RJ Mauger DT Rosenberg SR Sharp-King T White SR Woodruff PG Avila PC Denlinger LC Holguin F Lazarus SC Lugogo N Moore WC Peters SP Que L Smith LJ Sorkness CA Wechsler ME Wenzel SE Boushey HA Huang YJ . Features of the bronchial bacterial microbiome associated with atopy, asthma, and responsiveness to inhaled corticosteroid treatment. J Allergy Clin Immunol. 2017 Jul;140(1):63-75
[PubMed ID: 27838347]
Shen ZJ Hu J Kashi VP Kelly EA Denlinger LC Lutchman K McDonald JG Jarjour NN Malter JS . Epstein-Barr Virus-induced Gene 2 Mediates Allergen-induced Leukocyte Migration into Airways. Am J Respir Crit Care Med. 2017 Jun 15;195(12):1576-1585
[PubMed ID: 28125291]
Denlinger LC Phillips BR Ramratnam S Ross K Bhakta NR Cardet JC Castro M Peters SP Phipatanakul W Aujla S Bacharier LB Bleecker ER Comhair SA Coverstone A DeBoer M Erzurum SC Fain SB Fajt M Fitzpatrick AM Gaffin J Gaston B Hastie AT Hawkins GA Holguin F Irani AM Israel E Levy BD Ly N Meyers DA Moore WC Myers R Opina MT Peters MC Schiebler ML Sorkness RL Teague WG Wenzel SE Woodruff PG Mauger DT Fahy JV Jarjour NN . Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent Exacerbations. Am J Respir Crit Care Med. 2017 Feb 1;195(3):302-313
[PubMed ID: 27556234]
Denlinger LC King TS Cardet JC Craig T Holguin F Jackson DJ Kraft M Peters SP Ross K Sumino K Boushey HA Jarjour NN Wechsler ME Wenzel SE Castro M Avila PC . Vitamin D Supplementation and the Risk of Colds in Patients with Asthma. Am J Respir Crit Care Med. 2016 Mar 15;193(6):634-41
[PubMed ID: 26540136]
Levy BD Noel PJ Freemer MM Cloutier MM Georas SN Jarjour NN Ober C Woodruff PG Barnes KC Bender BG Camargo CA Jr Chupp GL Denlinger LC Fahy JV Fitzpatrick AM Fuhlbrigge A Gaston BM Hartert TV Kolls JK Lynch SV Moore WC Morgan WJ Nadeau KC Ownby DR Solway J Szefler SJ Wenzel SE Wright RJ Smith RA Erzurum SC . Future Research Directions in Asthma. An NHLBI Working Group Report. Am J Respir Crit Care Med. 2015 Dec 1;192(11):1366-72
[PubMed ID: 26305520]
Schwantes EA Denlinger LC Evans MD Gern JE Jarjour NN Mathur SK . Severity of virus-induced asthma symptoms is inversely related to resolution IFN-λ expression. J Allergy Clin Immunol. 2015 Jun;135(6):1656-9
[PubMed ID: 25784275]
Burnham ME Esnault S Roti Roti EC Bates ME Bertics PJ Denlinger LC . Cholesterol selectively regulates IL-5 induced mitogen activated protein kinase signaling in human eosinophils. PLoS One. 2014;9(8):e103122
[PubMed ID: 25121926]
Castro M King TS Kunselman SJ Cabana MD Denlinger L Holguin F Kazani SD Moore WC Moy J Sorkness CA Avila P Bacharier LB Bleecker E Boushey HA Chmiel J Fitzpatrick AM Gentile D Hundal M Israel E Kraft M Krishnan JA LaForce C Lazarus SC Lemanske R Lugogo N Martin RJ Mauger DT Naureckas E Peters SP Phipatanakul W Que LG Sheshadri A Smith L Solway J Sullivan-Vedder L Sumino K Wechsler ME Wenzel S White SR Sutherland ER . Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial. JAMA. 2014 May;311(20):2083-91
[PubMed ID: 24838406]
Karta MR Wickert LE Curran CS Gavala ML Denlinger LC Gern JE Bertics PJ . Allergen challenge in vivo alters rhinovirus-induced chemokine secretion from human airway macrophages. J Allergy Clin Immunol. 2014 Apr;133(4):1227-1230.e4
[PubMed ID: 24529411]
Esnault S Kelly EA Johansson MW Liu LY Han ST Akhtar M Sandbo N Mosher DF Denlinger LC Mathur SK Malter JS Jarjour NN . Semaphorin 7A is expressed on airway eosinophils and upregulated by IL-5 family cytokines. Clin Immunol. 2014 Jan;150(1):90-100
[PubMed ID: 24333536]
Burnham ME Koziol-White CJ Esnault S Bates ME Evans MD Bertics PJ Denlinger LC . Human airway eosinophils exhibit preferential reduction in STAT signaling capacity and increased CISH expression. J Immunol. 2013 Sep 15;191(6):2900-6
[PubMed ID: 23956426]
Johansson MW Kruger SJ Schiebler ML Evans MD Sorkness RL Denlinger LC Busse WW Jarjour NN Montgomery RR Mosher DF Fain SB . Markers of vascular perturbation correlate with airway structural change in asthma. Am J Respir Crit Care Med. 2013 Jul 15;188(2):167-78
[PubMed ID: 23855693]
Esnault S Kelly EA Schwantes EA Liu LY DeLain LP Hauer JA Bochkov YA Denlinger LC Malter JS Mathur SK Jarjour NN . Identification of genes expressed by human airway eosinophils after an in vivo allergen challenge. PLoS One. 2013;8(7):e67560
[PubMed ID: 23844029]
Wickert LE Blanchette JB Waldschmidt NV Bertics PJ Denu JM Denlinger LC Lenertz LY . The C-terminus of human nucleotide receptor P2X7 is critical for receptor oligomerization and N-linked glycosylation. PLoS One. 2013;8(5):e63789
[PubMed ID: 23691096]
Denlinger LC Manthei DM Seibold MA Ahn K Bleecker E Boushey HA Calhoun WJ Castro M Chinchili VM Fahy JV Hawkins GA Icitovic N Israel E Jarjour NN King T Kraft M Lazarus SC Lehman E Martin RJ Meyers DA Peters SP Sheerar D Shi L Sutherland ER Szefler SJ Wechsler ME Sorkness CA Lemanske RF Jr . P2X7-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapy. Am J Respir Crit Care Med. 2013 Jan 1;187(1):28-33
[PubMed ID: 23144325]
Denlinger LC Kelly EA Dodge AM McCartney JG Meyer KC Cornwell RD Jackson MJ Evans MD Jarjour NN . Safety of and cellular response to segmental bronchoprovocation in allergic asthma. PLoS One. 2013;8(1):e51963
[PubMed ID: 23341886]
Shi L Manthei DM Guadarrama AG Lenertz LY Denlinger LC . Rhinovirus-induced IL-1β release from bronchial epithelial cells is independent of functional P2X7. Am J Respir Cell Mol Biol. 2012 Sep;47(3):363-71
[PubMed ID: 22493010]
Manthei DM Jackson DJ Evans MD Gangnon RE Tisler CJ Gern JE Lemanske RF Jr Denlinger LC . Protection from asthma in a high-risk birth cohort by attenuated P2X(7) function. J Allergy Clin Immunol. 2012 Aug;130(2):496-502
[PubMed ID: 22743305]
Denlinger LC Sorkness RL Lee WM Evans MD Wolff MJ Mathur SK Crisafi GM Gaworski KL Pappas TE Vrtis RF Kelly EA Gern JE Jarjour NN . Lower airway rhinovirus burden and the seasonal risk of asthma exacerbation. Am J Respir Crit Care Med. 2011 Nov 1;184(9):1007-14
[PubMed ID: 21816938]