American Family Children's Hospital
Lee G. Wilke, MD close

Lee G. Wilke, MD Print Friendly Page

Faculty, University of Wisconsin School of Medicine and Public Health

Dr. Lee Wilke specializes in benign and malignant diseases of the breast; sentinel lymph-node mapping; neoadjuvant therapy for breast cancer; nipple-sparing breast surgery and minimally invasive surgery of the breast.

Dr. Wilke earned her medical degree from Duke University in Durham, N.C., and completed her residency and a research fellowship at the University of Michigan in Ann Arbor, Mich. She is certified by the American Board of Surgery and is the Director of the UW Health Breast Center.


Cancer Surgery

Surgery (General)

UW Health Clinics

UW Carbone Cancer Center
(608) 266-6400 | (800) 323-8942 | Map
University Hospital
(608) 266-6400 | (800) 323-8942 | Map
1 S. Park Clinic
(608) 287-2100 | (888) 703-2778 | Map

Regional Specialty Clinics

SwedishAmerican Regional Cancer Center (Rockford)
(779) 696-9400 |  Map

Hospital Affiliation(s)

University Hospital (primary)
Veterans Hospital - Wm. S. Middleton Memorial, UnityPoint Health - Meriter (secondary)

UW School of Medicine and Public Health

Department of Surgery

Professional Certifications and Education

Board Certification Surgery

ACS Resident Research Fellow in Immunotherapy, University of Michigan Hospitals, Ann Arbor, MI 1996-1998

Residency University of Michigan Hospitals, Ann Arbor, MI
Internship University of Michigan Hospitals, Ann Arbor, MI
Medical School Duke University School of Medicine, Durham, NC, 1993


UW Health Patient Experience Physician Champion Award 2015

Madison Magazine Top Docs 2014

Best Doctors® in America 2011

Medical interpreters are available to help patients communicate with hospital and clinic staff. For more information, please contact interpreter services at (608) 262-9000.


Our doctors provide a wide range of services. The following list represents some, but not all, of the procedures offered by this physician.

Programs & Conditions


Dr. Wilke’s main research interest are clinical trials that seek novel methods of treating breast cancer. She is a member of the executive committee of the American College of Surgeons Oncology Group, and also is a collaborator and investigator evaluating the use of optical spectroscopy to evaluate breast tumor margins and aid in the diagnosis and evaluation of solid tumors.

PubMed Articles
Boughey JC Ballman KV Le-Petross HT McCall LM Mittendorf EA Ahrendt GM Wilke LG Taback B Feliberti EC Hunt KK . Identification and Resection of Clipped Node Decreases the False-negative Rate of Sentinel Lymph Node Surgery in Patients Presenting With Node-positive Breast Cancer (T0-T4, N1-N2) Who Receive Neoadjuvant Chemotherapy: Results From ACOSOG Z1071 (Alliance). Ann Surg. 2016 Apr;263(4):802-7
[PubMed ID: 26649589]
Zumwalde NA Haag JD Sharma D Mirrielees JA Wilke LG Gould MN Gumperz JE . Analysis of Immune Cells from Human Mammary Ductal Epithelial Organoids Reveals Vδ2+ T Cells That Efficiently Target Breast Carcinoma Cells in the Presence of Bisphosphonate. Cancer Prev Res (Phila). 2016 Apr;9(4):305-16
[PubMed ID: 26811335]
Decker MR Trentham-Dietz A Loconte NK Neuman HB Smith MA Punglia RS Greenberg CC Wilke LG . The Role of Intraoperative Pathologic Assessment in the Surgical Management of Ductal Carcinoma In Situ. Ann Surg Oncol. 2016 Mar 29;
[PubMed ID: 27026436]
Neuman HB Steffens NM Jacobson N Tevaarwerk A Anderson B Wilke LG Greenberg CC . Oncologists' Perspectives of Their Roles and Responsibilities During Multi-disciplinary Breast Cancer Follow-Up. Ann Surg Oncol. 2016 Mar;23(3):708-14
[PubMed ID: 26474556]
Wilke LG Dickson-Witmer D Boughey JC . Dissemination and implementation: Translating cancer guidelines and clinical trial outcomes into everyday practice. Bull Am Coll Surg. 2016 Feb;101(2):33-4
[PubMed ID: 26995861]
Boughey JC Ballman KV Hunt KK McCall LM Mittendorf EA Ahrendt GM Wilke LG Le-Petross HT . Axillary Ultrasound After Neoadjuvant Chemotherapy and Its Impact on Sentinel Lymph Node Surgery: Results From the American College of Surgeons Oncology Group Z1071 Trial (Alliance). J Clin Oncol. 2015 Oct 20;33(30):3386-93
[PubMed ID: 25646192]
Mirrielees JA Breckheimer KR White TA Denure DA Schroeder MM Gaines ME Wilke LG Tevaarwerk AJ . Breast Cancer Survivor Advocacy at a University Hospital: Development of a Peer Support Program with Evaluation by Patients, Advocates, and Clinicians. J Cancer Educ. 2015 Oct 19;
[PubMed ID: 26477478]
Boughey JC Suman VJ Mittendorf EA Ahrendt GM Wilke LG Taback B Leitch AM Flippo-Morton TS Kuerer HM Bowling M Hunt KK . Factors affecting sentinel lymph node identification rate after neoadjuvant chemotherapy for breast cancer patients enrolled in ACOSOG Z1071 (Alliance). Ann Surg. 2015 Mar;261(3):547-52
[PubMed ID: 25664534]
Shlensky D Mirrielees JA Zhao Z Wang L Mahajan A Yu M Sherer NM Wilke LG Xu W . Correction: differential CARM1 isoform expression in subcellular compartments and among malignant and benign breast tumors. PLoS One. 2015;10(6):e0131955
[PubMed ID: 26110850]
Nichols BS Schindler CE Brown JQ Wilke LG Mulvey CS Krieger MS Gallagher J Geradts J Greenup RA Von Windheim JA Ramanujam N . A Quantitative Diffuse Reflectance Imaging (QDRI) System for Comprehensive Surveillance of the Morphological Landscape in Breast Tumor Margins. PLoS One. 2015;10(6):e0127525
[PubMed ID: 26076123]
Shlensky D Mirrielees JA Zhao Z Wang L Mahajan A Yu M Sherer NM Wilke LG Xu W . Differential CARM1 Isoform Expression in Subcellular Compartments and among Malignant and Benign Breast Tumors. PLoS One. 2015;10(6):e0128143
[PubMed ID: 26030442]
Van Zee KJ Hansen NM Barrio AV Connor CS Danforth DN Euhus DM Kulkarni SA McCready DR McLaughlin S Wilke LG . Commentary on the Canadian National Breast Screening study. Ann Surg Oncol. 2014 Dec;21(13):4397-8
[PubMed ID: 24859935]
Wilke LG Czechura T Wang C Lapin B Liederbach E Winchester DP Yao K . Repeat surgery after breast conservation for the treatment of stage 0 to II breast carcinoma: a report from the National Cancer Data Base, 2004-2010. JAMA Surg. 2014 Dec;149(12):1296-305
[PubMed ID: 25390819]
Boughey JC McCall LM Ballman KV Mittendorf EA Ahrendt GM Wilke LG Taback B Leitch AM Flippo-Morton T Hunt KK . Tumor biology correlates with rates of breast-conserving surgery and pathologic complete response after neoadjuvant chemotherapy for breast cancer: findings from the ACOSOG Z1071 (Alliance) Prospective Multicenter Clinical Trial. Ann Surg. 2014 Oct;260(4):608-14; discussion 614-6
[PubMed ID: 25203877]
Mirrielees JA Kapur JH Szalkucki LM Harter JM Salkowski LR Strigel RM Traynor AM Wilke LG . Metastasis of primary lung carcinoma to the breast: a systematic review of the literature. J Surg Res. 2014 May 15;188(2):419-31
[PubMed ID: 24560348]
Zasadil LM Andersen KA Yeum D Rocque GB Wilke LG Tevaarwerk AJ Raines RT Burkard ME Weaver BA . Cytotoxicity of paclitaxel in breast cancer is due to chromosome missegregation on multipolar spindles. Sci Transl Med. 2014 Mar 26;6(229):229ra43
[PubMed ID: 24670687]
Hornsby WE Douglas PS West MJ Kenjale AA Lane AR Schwitzer ER Ray KA Herndon JE 2nd Coan A Gutierrez A Hornsby KP Hamilton E Wilke LG Kimmick GG Peppercorn JM Jones LW . Safety and efficacy of aerobic training in operable breast cancer patients receiving neoadjuvant chemotherapy: a phase II randomized trial. Acta Oncol. 2014 Jan;53(1):65-74
[PubMed ID: 23957716]
Caretta-Weyer H Greenberg CG Wilke LG Weiss J LoConte NK Decker M Steffens NM Smith MA Neuman HB . Impact of the American College of Surgeons Oncology Group (ACOSOG) Z0011 trial on clinical management of the axilla in older breast cancer patients: a SEER-medicare analysis. Ann Surg Oncol. 2013 Dec;20(13):4145-52
[PubMed ID: 23959051]
Boughey JC Suman VJ Mittendorf EA Ahrendt GM Wilke LG Taback B Leitch AM Kuerer HM Bowling M Flippo-Morton TS Byrd DR Ollila DW Julian TB McLaughlin SA McCall L Symmans WF Le-Petross HT Haffty BG Buchholz TA Nelson H Hunt KK . Sentinel lymph node surgery after neoadjuvant chemotherapy in patients with node-positive breast cancer: the ACOSOG Z1071 (Alliance) clinical trial. JAMA. 2013 Oct 9;310(14):1455-61
[PubMed ID: 24101169]
Jones LW Fels DR West M Allen JD Broadwater G Barry WT Wilke LG Masko E Douglas PS Dash RC Povsic TJ Peppercorn J Marcom PK Blackwell KL Kimmick G Turkington TG Dewhirst MW . Modulation of circulating angiogenic factors and tumor biology by aerobic training in breast cancer patients receiving neoadjuvant chemotherapy. Cancer Prev Res (Phila). 2013 Sep;6(9):925-37
[PubMed ID: 23842792]