American Family Children's Hospital
Lee G. Wilke, MD, FACS close

Lee G. Wilke, MD, FACS Print Friendly Page

Director, UW Health Breast Center
Faculty, University of Wisconsin School of Medicine and Public Health

Dr. Lee Wilke specializes in benign and malignant diseases of the breast; sentinel lymph-node mapping; neoadjuvant therapy for breast cancer; nipple-sparing breast surgery and minimally invasive surgery of the breast.

Dr. Wilke earned her medical degree from Duke University in Durham, N.C., and completed her residency and a research fellowship at the University of Michigan in Ann Arbor, Mich. She is certified by the American Board of Surgery and is the Director of the UW Health Breast Center.


Cancer Surgery

Surgery (General)

UW Health Clinics

UW Carbone Cancer Center
(608) 266-6400 | (800) 323-8942 | Map
University Hospital
(608) 266-6400 | (800) 323-8942 | Map
UW Health Surgery at SwedishAmerican
(779) 696-8700 | Map
1 S. Park Clinic
(608) 287-2100 | (888) 703-2778 | Map

Hospital Affiliation(s)

University Hospital (primary)
Veterans Hospital - Wm. S. Middleton Memorial, UnityPoint Health - Meriter (secondary)

UW School of Medicine and Public Health

Department of Surgery

Professional Certifications and Education

Board Certification Surgery

ACS Resident Research Fellow in Immunotherapy, University of Michigan Hospitals, Ann Arbor, MI 1996-1998

Residency University of Michigan Hospitals, Ann Arbor, MI
Internship University of Michigan Hospitals, Ann Arbor, MI
Medical School Duke University School of Medicine, Durham, NC, 1993


UW Health Patient Experience Physician Champion Award 2015

Madison Magazine Top Docs 2014

Best Doctors® in America 2011

Medical interpreters are available to help patients communicate with hospital and clinic staff. For more information, please contact interpreter services at (608) 262-9000.


Our doctors provide a wide range of services. The following list represents some, but not all, of the procedures offered by this physician.

Programs & Conditions


Dr. Wilke’s main research interest are clinical trials that seek novel methods of treating breast cancer. She is a member of the executive committee of the American College of Surgeons Oncology Group, and also is a collaborator and investigator evaluating the use of optical spectroscopy to evaluate breast tumor margins and aid in the diagnosis and evaluation of solid tumors.

PubMed Articles
Schumacher JR Taylor LJ Tucholka JL Poore S Eggen A Steiman J Wilke LG Greenberg CC Neuman HB . Socioeconomic Factors Associated with Post-Mastectomy Immediate Reconstruction in a Contemporary Cohort of Breast Cancer Survivors. Ann Surg Oncol. 2017 Aug 1;
[PubMed ID: 28766209]
Landercasper J Bennie B Parsons BM Dietrich LL Greenberg CC Wilke LG Linebarger JH . Fewer Reoperations After Lumpectomy for Breast Cancer with Neoadjuvant Rather than Adjuvant Chemotherapy: A Report from the National Cancer Database. Ann Surg Oncol. 2017 Jun;24(6):1507-1515
[PubMed ID: 28062931]
DuBenske LL Schrager S McDowell H Wilke LG Trentham-Dietz A Burnside ES . Mammography Screening: Gaps in Patient's and Physician's Needs for Shared Decision-Making. Breast J. 2017 Mar;23(2):210-214
[PubMed ID: 28252231]
Mirrielees JA Breckheimer KR White TA Denure DA Schroeder MM Gaines ME Wilke LG Tevaarwerk AJ . Breast Cancer Survivor Advocacy at a University Hospital: Development of a Peer Support Program with Evaluation by Patients, Advocates, and Clinicians. J Cancer Educ. 2017 Mar;32(1):97-104
[PubMed ID: 26477478]
Hunt KK Euhus DM Boughey JC Chagpar AB Feldman SM Hansen NM Kulkarni SA McCready DR Mamounas EP Wilke LG Van Zee KJ Morrow M . Society of Surgical Oncology Breast Disease Working Group Statement on Prophylactic (Risk-Reducing) Mastectomy. Ann Surg Oncol. 2017 Feb;24(2):375-397
[PubMed ID: 27933411]
Schulman AM Mirrielees JA Leverson G Landercasper J Greenberg C Wilke LG . Reexcision Surgery for Breast Cancer: An Analysis of the American Society of Breast Surgeons (ASBrS) MasterySM Database Following the SSO-ASTRO "No Ink on Tumor" Guidelines. Ann Surg Oncol. 2017 Jan;24(1):52-58
[PubMed ID: 27581607]
Boughey JC Attai DJ Chen SL Cody HS Dietz JR Feldman SM Greenberg CC Kass RB Landercasper J Lemaine V MacNeill F Margenthaler JA Song DH Staley AC Wilke LG Willey SC Yao KA . Contralateral Prophylactic Mastectomy Consensus Statement from the American Society of Breast Surgeons: Additional Considerations and a Framework for Shared Decision Making. Ann Surg Oncol. 2016 Oct;23(10):3106-11
[PubMed ID: 27469118]
Boughey JC Attai DJ Chen SL Cody HS Dietz JR Feldman SM Greenberg CC Kass RB Landercasper J Lemaine V MacNeill F Song DH Staley AC Wilke LG Willey SC Yao KA Margenthaler JA . Contralateral Prophylactic Mastectomy┬á(CPM) Consensus Statement from the American Society of Breast Surgeons: Data on CPM Outcomes and Risks. Ann Surg Oncol. 2016 Oct;23(10):3100-5
[PubMed ID: 27469117]
Adesoye T Neuman HB Wilke LG Schumacher JR Steiman J Greenberg CC . Current Trends in the Management of Phyllodes Tumors of the Breast. Ann Surg Oncol. 2016 Oct;23(10):3199-205
[PubMed ID: 27334214]
Decker MR Trentham-Dietz A Loconte NK Neuman HB Smith MA Punglia RS Greenberg CC Wilke LG . The Role of Intraoperative Pathologic Assessment in the Surgical Management of Ductal Carcinoma In Situ. Ann Surg Oncol. 2016 Sep;23(9):2788-94
[PubMed ID: 27026436]
Neuman HB Jacobs EA Steffens NM Jacobson N Tevaarwerk A Wilke LG Tucholka J Greenberg CC . Oncologists' perceived barriers to an expanded role for primary care in breast cancer survivorship care. Cancer Med. 2016 Sep;5(9):2198-204
[PubMed ID: 27356781]
Boughey JC Ballman KV Le-Petross HT McCall LM Mittendorf EA Ahrendt GM Wilke LG Taback B Feliberti EC Hunt KK . Identification and Resection of Clipped Node Decreases the False-negative Rate of Sentinel Lymph Node Surgery in Patients Presenting With Node-positive Breast Cancer (T0-T4, N1-N2) Who Receive Neoadjuvant Chemotherapy: Results From ACOSOG Z1071 (Alliance). Ann Surg. 2016 Apr;263(4):802-7
[PubMed ID: 26649589]
Zumwalde NA Haag JD Sharma D Mirrielees JA Wilke LG Gould MN Gumperz JE . Analysis of Immune Cells from Human Mammary Ductal Epithelial Organoids Reveals V╬┤2+ T Cells That Efficiently Target Breast Carcinoma Cells in the Presence of Bisphosphonate. Cancer Prev Res (Phila). 2016 Apr;9(4):305-16
[PubMed ID: 26811335]
Neuman HB Steffens NM Jacobson N Tevaarwerk A Anderson B Wilke LG Greenberg CC . Oncologists' Perspectives of Their Roles and Responsibilities During Multi-disciplinary Breast Cancer Follow-Up. Ann Surg Oncol. 2016 Mar;23(3):708-14
[PubMed ID: 26474556]
Wilke LG Dickson-Witmer D Boughey JC . Dissemination and implementation: Translating cancer guidelines and clinical trial outcomes into everyday practice. Bull Am Coll Surg. 2016 Feb;101(2):33-4
[PubMed ID: 26995861]
Boughey JC Ballman KV Hunt KK McCall LM Mittendorf EA Ahrendt GM Wilke LG Le-Petross HT . Axillary Ultrasound After Neoadjuvant Chemotherapy and Its Impact on Sentinel Lymph Node Surgery: Results From the American College of Surgeons Oncology Group Z1071 Trial (Alliance). J Clin Oncol. 2015 Oct 20;33(30):3386-93
[PubMed ID: 25646192]
Shlensky D Mirrielees JA Zhao Z Wang L Mahajan A Yu M Sherer NM Wilke LG Xu W . Correction: differential CARM1 isoform expression in subcellular compartments and among malignant and benign breast tumors. PLoS One. 2015;10(6):e0131955
[PubMed ID: 26110850]
Nichols BS Schindler CE Brown JQ Wilke LG Mulvey CS Krieger MS Gallagher J Geradts J Greenup RA Von Windheim JA Ramanujam N . A Quantitative Diffuse Reflectance Imaging (QDRI) System for Comprehensive Surveillance of the Morphological Landscape in Breast Tumor Margins. PLoS One. 2015;10(6):e0127525
[PubMed ID: 26076123]
Shlensky D Mirrielees JA Zhao Z Wang L Mahajan A Yu M Sherer NM Wilke LG Xu W . Differential CARM1 Isoform Expression in Subcellular Compartments and among Malignant and Benign Breast Tumors. PLoS One. 2015;10(6):e0128143
[PubMed ID: 26030442]
Boughey JC Suman VJ Mittendorf EA Ahrendt GM Wilke LG Taback B Leitch AM Flippo-Morton TS Kuerer HM Bowling M Hunt KK . Factors affecting sentinel lymph node identification rate after neoadjuvant chemotherapy for breast cancer patients enrolled in ACOSOG Z1071 (Alliance). Ann Surg. 2015 Mar;261(3):547-52
[PubMed ID: 25664534]