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Jonathan C. Makielski, MD, FACC close
Jonathan C. Makielski, MD, FACC


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Jonathan C. Makielski, MD, FACC Print Friendly Page

Faculty, University of Wisconsin School of Medicine and Public Health

A Fellow of the American College of Cardiology, Dr. Makielski is board certified in internal medicine and in the subspecialty of cardiovascular diseases (cardiology). Recognized as an excellent teacher both in clinical and scientific settings, Dr. Makielski formally lectures to graduate students in physiology, genetics, pharmacology and toxicology. Nationally, he has participated as a lecturer in numerous courses and tutorials. As a clinician-investigator, Dr. Makielski has developed a distinguished NIH-funded research career in molecular electrophysiology.

Specialties

Cardiovascular Medicine

UW Health Clinics

West Clinic
(608) 263-1530 | (800) 323-8942 | Map

Hospital Affiliation(s)

University of Wisconsin Hospital and Clinics (primary)

UW School of Medicine and Public Health

Department of Medicine

Professional Certifications and Education

Board Certification Internal Medicine
Cardiovascular Disease
Fellowship University of Chicago Medical Center, Chicago, IL
Residency North Carolina Memorial Hospital
Internship North Carolina Memorial Hospital
Medical School University of Chicago Medical School, Chicago, IL, 1979

Medical interpreters are available to help patients communicate with hospital and clinic staff. For more information, please contact interpreter services at (608) 262-9000.

Programs & Conditions

Research

Dr. Makielski 's research has been continuously funded by the NIH since 1985 and he is a leader in ion channels research employing molecular biological and electrophysiological methods. His interests include the genetic basis of arrhythmia, such as the Burgada syndrome and long QT syndrome, with a focus on the cardiac sodium channel. Dr. Makielski is also studying the ATP-dependent potassium channel and its role in ischemia and ischemic preconditioning in the heart.


PubMed Articles
Lin EC Moungey BM Lim E Concannon SP Anderson CL Kyle JW Makielski JC Balijepalli SY January CT . Mouse ERG K+ Channel Clones Reveal Differences in Protein Trafficking and Function. J Am Heart Assoc. 2014 Dec 11;3(6)
[PubMed ID: 25497881]
Kyle JW Makielski JC . Diseases caused by mutations in Nav1.5 interacting proteins. Card Electrophysiol Clin. 2014 Dec 1;6(4):797-809
[PubMed ID: 25395996]
Spencer CI Baba S Nakamura K Hua EA Sears MA Fu CC Zhang J Balijepalli S Tomoda K Hayashi Y Lizarraga P Wojciak J Scheinman MM Aalto-Setälä K Makielski JC January CT Healy KE Kamp TJ Yamanaka S Conklin BR . Calcium transients closely reflect prolonged action potentials in iPSC models of inherited cardiac arrhythmia. Stem Cell Reports. 2014 Aug 12;3(2):269-81
[PubMed ID: 25254341]
Fahrenbach JP Stoller D Kim G Aggarwal N Yerokun B Earley JU Hadhazy M Shi NQ Makielski JC McNally EM . Abcc9 is required for the transition to oxidative metabolism in the newborn heart. FASEB J. 2014 Jul;28(7):2804-15
[PubMed ID: 24648545]
Kalscheur MM Vaidyanathan R Orland KM Abozeid S Fabry N Maginot KR January CT Makielski JC Eckhardt LL . KCNJ2 mutation causes an adrenergic-dependent rectification abnormality with calcium sensitivity and ventricular arrhythmia. Heart Rhythm. 2014 May;11(5):885-94
[PubMed ID: 24561538]
Liu C Tester DJ Hou Y Wang W Lv G Ackerman MJ Makielski JC Cheng J . Is sudden unexplained nocturnal death syndrome in Southern China a cardiac sodium channel dysfunction disorder? Forensic Sci Int. 2014 Mar;236:38-45
[PubMed ID: 24529773]
Aggarwal NT Shi NQ Makielski JC . ATP-sensitive potassium currents from channels formed by Kir6 and a modified cardiac mitochondrial SUR2 variant. Channels (Austin). 2013 Nov-Dec;7(6):493-502
[PubMed ID: 24037327]
Adsit GS Vaidyanathan R Galler CM Kyle JW Makielski JC . Channelopathies from mutations in the cardiac sodium channel protein complex. J Mol Cell Cardiol. 2013 Aug;61:34-43
[PubMed ID: 23557754]
Cheng J Valdivia CR Vaidyanathan R Balijepalli RC Ackerman MJ Makielski JC . Caveolin-3 suppresses late sodium current by inhibiting nNOS-dependent S-nitrosylation of SCN5A. J Mol Cell Cardiol. 2013 Aug;61:102-10
[PubMed ID: 23541953]
Vaidyanathan R Vega AL Song C Zhou Q Tan BH Berger S Makielski JC Eckhardt LL . The interaction of caveolin 3 protein with the potassium inward rectifier channel Kir2.1: physiology and pathology related to long qt syndrome 9 (LQT9). J Biol Chem. 2013 Jun 14;288(24):17472-80
[PubMed ID: 23640888]
Aggarwal NT Makielski JC . Redox control of cardiac excitability. Antioxid Redox Signal. 2013 Feb 1;18(4):432-68
[PubMed ID: 22897788]
Cheng J Norstrand DW Medeiros-Domingo A Tester DJ Valdivia CR Tan BH Vatta M Makielski JC Ackerman MJ . LQTS-associated mutation A257G in α1-syntrophin interacts with the intragenic variant P74L to modify its biophysical phenotype. Cardiogenetics. 2011 Oct 25;1(1)
[PubMed ID: 24319568]
Mottram AR Valdivia CR Makielski JC . Fatty acids antagonize bupivacaine-induced I(Na) blockade. Clin Toxicol (Phila). 2011 Oct;49(8):729-33
[PubMed ID: 21970771]
Cheng J Tester DJ Tan BH Valdivia CR Kroboth S Ye B January CT Ackerman MJ Makielski JC . The common African American polymorphism SCN5A-S1103Y interacts with mutation SCN5A-R680H to increase late Na current. Physiol Genomics. 2011 May 13;43(9):461-6
[PubMed ID: 21385947]
Aggarwal NT Pravdic D McNally EM Bosnjak ZJ Shi NQ Makielski JC . The mitochondrial bioenergetic phenotype for protection from cardiac ischemia in SUR2 mutant mice. Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1884-90
[PubMed ID: 20935152]
Cheng J Morales A Siegfried JD Li D Norton N Song J Gonzalez-Quintana J Makielski JC Hershberger RE . SCN5A rare variants in familial dilated cardiomyopathy decrease peak sodium current depending on the common polymorphism H558R and common splice variant Q1077del. Clin Transl Sci. 2010 Dec;3(6):287-94
[PubMed ID: 21167004]
Valdivia CR Medeiros-Domingo A Ye B Shen WK Algiers TJ Ackerman MJ Makielski JC . Loss-of-function mutation of the SCN3B-encoded sodium channel {beta}3 subunit associated with a case of idiopathic ventricular fibrillation. Cardiovasc Res. 2010 Jun 1;86(3):392-400
[PubMed ID: 20042427]
Tan BH Pundi KN Van Norstrand DW Valdivia CR Tester DJ Medeiros-Domingo A Makielski JC Ackerman MJ . Sudden infant death syndrome-associated mutations in the sodium channel beta subunits. Heart Rhythm. 2010 Jun;7(6):771-8
[PubMed ID: 20226894]
Cheng J Van Norstrand DW Medeiros-Domingo A Valdivia C Tan BH Ye B Kroboth S Vatta M Tester DJ January CT Makielski JC Ackerman MJ . Alpha1-syntrophin mutations identified in sudden infant death syndrome cause an increase in late cardiac sodium current. Circ Arrhythm Electrophysiol. 2009 Dec;2(6):667-76
[PubMed ID: 20009079]
Ye B Kroboth SL Pu JL Sims JJ Aggarwal NT McNally EM Makielski JC Shi NQ . Molecular identification and functional characterization of a mitochondrial sulfonylurea receptor 2 splice variant generated by intraexonic splicing. Circ Res. 2009 Nov 20;105(11):1083-93
[PubMed ID: 19797704]