Jonathan C. Makielski, MD, FACC Print Friendly PageFaculty, University of Wisconsin School of Medicine and Public Health
A Fellow of the American College of Cardiology, Dr. Makielski is board certified in internal medicine and in the subspecialty of cardiovascular diseases (cardiology). Recognized as an excellent teacher both in clinical and scientific settings, Dr. Makielski formally lectures to graduate students in physiology, genetics, pharmacology and toxicology. Nationally, he has participated as a lecturer in numerous courses and tutorials. As a clinician-investigator, Dr. Makielski has developed a distinguished NIH-funded research career in molecular electrophysiology.
UW School of Medicine and Public Health
|Department of Medicine|
Professional Certifications and Education
University of Chicago Medical Center, Chicago, IL
North Carolina Memorial Hospital
North Carolina Memorial Hospital
University of Chicago Medical School, Chicago, IL, 1979
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Programs & Conditions
Dr. Makielski 's research has been continuously funded by the NIH since 1985 and he is a leader in ion channels research employing molecular biological and electrophysiological methods. His interests include the genetic basis of arrhythmia, such as the Burgada syndrome and long QT syndrome, with a focus on the cardiac sodium channel. Dr. Makielski is also studying the ATP-dependent potassium channel and its role in ischemia and ischemic preconditioning in the heart.
Makielski JC Kyle JW .
Late INa in the Heart: Physiology, Pathology, and Pathways. Circulation. 2015 Jul 17;
[PubMed ID: 26187181]
Yang KC Kyle JW Makielski JC Dudley SC Jr .
Mechanisms of sudden cardiac death: oxidants and metabolism. Circ Res. 2015 Jun 5;116(12):1937-55
[PubMed ID: 26044249]
Makielski JC .
Late sodium current: A mechanism for angina, heart failure, and arrhythmia. Trends Cardiovasc Med. 2015 May 22;
[PubMed ID: 26092781]
Kapplinger JD Giudicessi JR Ye D Tester DJ Callis TE Valdivia CR Makielski JC Wilde AA Ackerman MJ .
Enhanced Classification of Brugada Syndrome- and Long QT Syndrome-Associated Genetic Variants in the SCN5A-Encoded Nav1.5 Cardiac Sodium Channel. Circ Cardiovasc Genet. 2015 Apr 22;
[PubMed ID: 25904541]
January CT Makielski JC .
In memoriam: Harry A. Fozzard, MD, April 22, 1931-December 9, 2014. Heart Rhythm. 2015 Apr;12(4):855
[PubMed ID: 25800155]
Hu RM Tan BH Tester DJ Song C He Y Dovat S Peterson BZ Ackerman MJ Makielski JC .
Arrhythmogenic Biophysical Phenotype for SCN5A Mutation S1787N Depends upon Splice Variant Background and Intracellular Acidosis. PLoS One. 2015;10(4):e0124921
[PubMed ID: 25923670]
Lin EC Moungey BM Lim E Concannon SP Anderson CL Kyle JW Makielski JC Balijepalli SY January CT .
Mouse ERG K(+) channel clones reveal differences in protein trafficking and function. J Am Heart Assoc. 2014 Dec 11;3(6):e001491
[PubMed ID: 25497881]
Kyle JW Makielski JC .
Diseases caused by mutations in Nav1.5 interacting proteins. Card Electrophysiol Clin. 2014 Dec 1;6(4):797-809
[PubMed ID: 25395996]
Spencer CI Baba S Nakamura K Hua EA Sears MA Fu CC Zhang J Balijepalli S Tomoda K Hayashi Y Lizarraga P Wojciak J Scheinman MM Aalto-Setälä K Makielski JC January CT Healy KE Kamp TJ Yamanaka S Conklin BR .
Calcium transients closely reflect prolonged action potentials in iPSC models of inherited cardiac arrhythmia. Stem Cell Reports. 2014 Aug 12;3(2):269-81
[PubMed ID: 25254341]
Fahrenbach JP Stoller D Kim G Aggarwal N Yerokun B Earley JU Hadhazy M Shi NQ Makielski JC McNally EM .
Abcc9 is required for the transition to oxidative metabolism in the newborn heart. FASEB J. 2014 Jul;28(7):2804-15
[PubMed ID: 24648545]
Kalscheur MM Vaidyanathan R Orland KM Abozeid S Fabry N Maginot KR January CT Makielski JC Eckhardt LL .
KCNJ2 mutation causes an adrenergic-dependent rectification abnormality with calcium sensitivity and ventricular arrhythmia. Heart Rhythm. 2014 May;11(5):885-94
[PubMed ID: 24561538]
Liu C Tester DJ Hou Y Wang W Lv G Ackerman MJ Makielski JC Cheng J .
Is sudden unexplained nocturnal death syndrome in Southern China a cardiac sodium channel dysfunction disorder? Forensic Sci Int. 2014 Mar;236:38-45
[PubMed ID: 24529773]
Aggarwal NT Shi NQ Makielski JC .
ATP-sensitive potassium currents from channels formed by Kir6 and a modified cardiac mitochondrial SUR2 variant. Channels (Austin). 2013 Nov-Dec;7(6):493-502
[PubMed ID: 24037327]
Adsit GS Vaidyanathan R Galler CM Kyle JW Makielski JC .
Channelopathies from mutations in the cardiac sodium channel protein complex. J Mol Cell Cardiol. 2013 Aug;61:34-43
[PubMed ID: 23557754]
Cheng J Valdivia CR Vaidyanathan R Balijepalli RC Ackerman MJ Makielski JC .
Caveolin-3 suppresses late sodium current by inhibiting nNOS-dependent S-nitrosylation of SCN5A. J Mol Cell Cardiol. 2013 Aug;61:102-10
[PubMed ID: 23541953]
Vaidyanathan R Vega AL Song C Zhou Q Tan BH Berger S Makielski JC Eckhardt LL .
The interaction of caveolin 3 protein with the potassium inward rectifier channel Kir2.1: physiology and pathology related to long qt syndrome 9 (LQT9). J Biol Chem. 2013 Jun 14;288(24):17472-80
[PubMed ID: 23640888]
Aggarwal NT Makielski JC .
Redox control of cardiac excitability. Antioxid Redox Signal. 2013 Feb 1;18(4):432-68
[PubMed ID: 22897788]
Cheng J Norstrand DW Medeiros-Domingo A Tester DJ Valdivia CR Tan BH Vatta M Makielski JC Ackerman MJ .
LQTS-associated mutation A257G in α1-syntrophin interacts with the intragenic variant P74L to modify its biophysical phenotype. Cardiogenetics. 2011 Oct 25;1(1)
[PubMed ID: 24319568]
Mottram AR Valdivia CR Makielski JC .
Fatty acids antagonize bupivacaine-induced I(Na) blockade. Clin Toxicol (Phila). 2011 Oct;49(8):729-33
[PubMed ID: 21970771]
Cheng J Tester DJ Tan BH Valdivia CR Kroboth S Ye B January CT Ackerman MJ Makielski JC .
The common African American polymorphism SCN5A-S1103Y interacts with mutation SCN5A-R680H to increase late Na current. Physiol Genomics. 2011 May 13;43(9):461-6
[PubMed ID: 21385947]