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John S. Kuo, MD, PhD close

John S. Kuo, MD, PhD Print Friendly Page

Faculty, University of Wisconsin School of Medicine and Public Health

Dr. Kuo is assistant professor of Neurological Surgery and Human Oncology and Director of the Comprehensive Brain Tumor Program at University of Wisconsin Hospital and Clinics. He specializes in treating benign and malignant brain and spinal tumors (i.e., GBM, pituitary tumor, meningioma, astrocytoma, metastatic cancer to brain), with special expertise in stereotactic radiosurgery for tumors, vascular lesions and trigeminal neuralgia. He co-directs the UW Comprehensive Cancer Center multidisciplinary Brain Tumor Clinic, and started the new, multidisciplinary Pituitary Tumor Clinic with colleagues in endocrinology, neuro-oncology, radiation oncology and neuro-ophthalmology. Dr. Kuo chairs the UW Comprehensive Cancer Center CNS Tumors Group, a national leader for clinical trials of new brain tumor therapies, and performs molecular biology research on cancer stem cells.

Specialties

Neurosurgery

UW Health Clinics

UW Carbone Cancer Center
(608) 263-8500 | (800) 323-8942 | Map
UW Hospital and Clinics
(608) 263-7502 | (800) 323-8942 | Map
UW Hospital and Clinics
(608) 263-7502 | (800) 323-8942 | Map

Hospital Affiliation(s)

University of Wisconsin Hospital and Clinics (primary)

Languages Spoken

English
Medical interpreters are available to help patients communicate with hospital and clinic staff. For more information, please contact interpreter services at (608) 262-9000.

UW School of Medicine and Public Health

Department of Neurological Surgery

Professional Certifications and Education

Board Certification Neurological Surgery
Fellowship University of Toronto (Labatt Brain Tumor Research Center)
University of Southern California (Norris Comphrehensive Cancer Center)
Residency University of Southern California
Internship University of Southern California
Medical School Harvard Medical School, MIT Division of Health Sciences and Technology

Procedures

Our doctors provide a wide range of services. The following list represents some, but not all, of the procedures offered by this physician.

Programs & Conditions

Research

Dr. Kuo’s research focuses on understanding the genesis of brain tumors, with the goal of developing novel therapies. He has investigated the radiosurgical management of brain tumors and the potential clinical use of novel gene markers in medulloblastomas. The Brain Tumor Research Laboratory is currently focused on the molecular biology of brain tumor stem cells and collaborating with other UW scientists to define possible molecular mechanisms of tumor stem cell pathogenesis to develop novel diagnostic and therapeutic strategies.

PubMed Articles
Voss J Meier TB Freidel R Kundu B Nair VA Holdsworth R Kuo JS Prabhakaran V . The role of secondary motor and language cortices in morbidity and mortality: a retrospective functional MRI study of surgical planning for patients with intracranial tumors. Neurosurg Focus. 2013 Apr;34(4):E7
[PubMed ID: 23544413]
Kundu B Penwarden A Wood JM Gallagher TA Andreoli MJ Voss J Meier T Nair VA Kuo JS Field AS Moritz C Meyerand ME Prabhakaran V . Association of functional magnetic resonance imaging indices with postoperative language outcomes in patients with primary brain tumors. Neurosurg Focus. 2013 Apr;34(4):E6
[PubMed ID: 23544412]
Zorniak M Clark PA Leeper HE Tipping MD Francis DM Kozak KR Salamat MS Kuo JS . Differential expression of 2',3'-cyclic-nucleotide 3'-phosphodiesterase and neural lineage markers correlate with glioblastoma xenograft infiltration and patient survival. Clin Cancer Res. 2012 Jul 1;18(13):3628-36
[PubMed ID: 22589395]
Clark PA Iida M Treisman DM Kalluri H Ezhilan S Zorniak M Wheeler DL Kuo JS . Activation of multiple ERBB family receptors mediates glioblastoma cancer stem-like cell resistance to EGFR-targeted inhibition. Neoplasia. 2012 May;14(5):420-8
[PubMed ID: 22745588]
Algharabil J Kintner DB Wang Q Begum G Clark PA Yang SS Lin SH Kahle KT Kuo JS Sun D . Inhibition of Na(+)-K(+)-2Cl(-) cotransporter isoform 1 accelerates temozolomide-mediated apoptosis in glioblastoma cancer cells. Cell Physiol Biochem. 2012;30(1):33-48
[PubMed ID: 22759954]
Ranganathan P Clark PA Kuo JS Salamat MS Kalejta RF . Significant association of multiple human cytomegalovirus genomic Loci with glioblastoma multiforme samples. J Virol. 2012 Jan;86(2):854-64
[PubMed ID: 22090104]
Huang Y Agrawal B Clark PA Williams JC Kuo JS . Evaluation of cancer stem cell migration using compartmentalizing microfluidic devices and live cell imaging. J Vis Exp. 2011 Dec 23;(58):e3297
[PubMed ID: 22217858]
Upton DC Welham NV Kuo JS Walker JW Pasic TR . Chronic rhinosinusitis with nasal polyps: a proteomic analysis. Ann Otol Rhinol Laryngol. 2011 Dec;120(12):780-6
[PubMed ID: 22279949]
Baggott CD Einstein MH Miranpuri A Rose SL Kuo JS . What is the optimal venous thromboembolism prophylaxis for gynecological oncology patients with CNS metastases? Gynecol Oncol. 2011 Nov;123(2):409-10
[PubMed ID: 21807402]
Ebben JD Zorniak M Clark PA Kuo JS . Introduction to induced pluripotent stem cells: advancing the potential for personalized medicine. World Neurosurg. 2011 Sep-Oct;76(3-4):270-5
[PubMed ID: 21986423]
Miranpuri AS Rajpal S Salamat MS Kuo JS . Upper cervical intramedullary spinal metastasis of ovarian carcinoma: a case report and review of the literature. J Med Case Rep. 2011 Jul 14;5:311
[PubMed ID: 21756304]
Thomas S Mehta MP Kuo JS Ian Robins H Khuntia D . Current practices of driving restriction implementation for patients with brain tumors. J Neurooncol. 2011 Jul;103(3):641-7
[PubMed ID: 20972603]
Gondi V Tolakanahalli R Mehta MP Tewatia D Rowley H Kuo JS Khuntia D Tomé WA . Hippocampal-sparing whole-brain radiotherapy: a "how-to" technique using helical tomotherapy and linear accelerator-based intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys. 2010 Nov 15;78(4):1244-52
[PubMed ID: 20598457]
Rocque BG Kuo JS Dempsey RJ . The University of Wisconsin department of neurological surgery. Neurosurgery. 2010 Aug;67(2):424-30
[PubMed ID: 20644429]
Ebben JD Treisman DM Zorniak M Kutty RG Clark PA Kuo JS . The cancer stem cell paradigm: a new understanding of tumor development and treatment. Expert Opin Ther Targets. 2010 Jun;14(6):621-32
[PubMed ID: 20426697]
Gondi V Tome WA Marsh J Struck A Ghia A Turian JV Bentzen SM Kuo JS Khuntia D Mehta MP . Estimated risk of perihippocampal disease progression after hippocampal avoidance during whole-brain radiotherapy: safety profile for RTOG 0933. Radiother Oncol. 2010 Jun;95(3):327-31
[PubMed ID: 20392503]
Rocque BG Herold KA Salamat MS Shenker Y Kuo JS . Symptomatic hyperprolactinemia from an ectopic pituitary adenoma located in the clivus. Endocr Pract. 2009 Mar;15(2):143-8
[PubMed ID: 19289326]
Ebben JD Rocque BG Kuo JS . Tumour vaccine approaches for CNS malignancies: progress to date. Drugs. 2009;69(3):241-9
[PubMed ID: 19275269]
Clark PA Treisman DM Ebben J Kuo JS . Developmental signaling pathways in brain tumor-derived stem-like cells. Dev Dyn. 2007 Dec;236(12):3297-308
[PubMed ID: 18000980]
Ghia A Tomé WA Thomas S Cannon G Khuntia D Kuo JS Mehta MP . Distribution of brain metastases in relation to the hippocampus: implications for neurocognitive functional preservation. Int J Radiat Oncol Biol Phys. 2007 Jul 15;68(4):971-7
[PubMed ID: 17446005]