George Wilding, MD Print Friendly PageFaculty, University of Wisconsin School of Medicine and Public Health
George Wilding, MD, was named Interim Director in 2002 and was Director of the University of Wisconsin Carbone Cancer Center from 2004 to 2013. A nationally renowned prostate cancer researcher, Wilding is the Donald and Marilyn Anderson professor of medicine.
A native of Everett, Massachusetts, Wilding graduated from the University of Massachusetts Medical School, where he also completed his internship and residency in Internal Medicine. He underwent training in Medical Oncology within the Medicine Branch at the National Cancer Institute. He has a master's degree (pharmacology) from Pennsylvania State University and bachelor's degrees from Tufts University (chemical engineering and biology).
UW Health Clinics
UW School of Medicine and Public Health
|Department of Medicine|
Professional Certifications and Education
National Cancer Institute, NIH, Bethesda, MD
University of Massachusetts Medical School, Worcester
University of Massachusetts Medical School, Worcester
University of Massachusetts Medical School, Worcester, MA, 1980
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In his clinical practice, Wilding sees patients with genitourinary cancers, including prostate, kidney, testicular and bladder cancers. From 1995 to 2003, he directed the UW Carbone Cancer Center Experimental Therapeutics Program, which seeks to identify new anti-cancer agents in the laboratory and translate them into clinical treatments with human patients. He served as chairman of the Genitourinary Cancer Committee of the Eastern Cooperative Oncology Group, a National Cancer Institute (NCI)-sponsored clinical research group for 10 years until 2003, and serves on numerous NCI, industry and foundation advisory and review boards.
Huang W Eickhoff JC Mehraein-Ghomi F Church DR Wilding G Basu HS .
Expression of spermidine/spermine N(1) -acetyl transferase (SSAT) in human prostate tissues is related to prostate cancer progression and metastasis. Prostate. 2015 Aug;75(11):1150-9
[PubMed ID: 25893668]
Huang SX Yun BS Ma M Basu HS Church DR Ingenhorst G Huang Y Yang D Lohman JR Tang GL Ju J Liu T Wilding G Shen B .
Leinamycin E1 acting as an anticancer prodrug activated by reactive oxygen species. Proc Natl Acad Sci U S A. 2015 Jun 8;
[PubMed ID: 26056295]
Wisinski KB Cantu CA Eickhoff J Osterby K Tevaarwerk AJ Heideman J Liu G Wilding G Johnston S Kolesar JM .
Potential cytochrome P-450 drug-drug interactions in adults with metastatic solid tumors and effect on eligibility for Phase I clinical trials. Am J Health Syst Pharm. 2015 Jun 1;72(11):958-65
[PubMed ID: 25987691]
DiPaola RS Chen YH Bubley GJ Stein MN Hahn NM Carducci MA Lattime EC Gulley JL Arlen PM Butterfield LH Wilding G .
A National Multicenter Phase 2 Study of Prostate-specific Antigen (PSA) Pox Virus Vaccine with Sequential Androgen Ablation Therapy in Patients with PSA Progression: ECOG 9802. Eur Urol. 2014 Dec 18;
[PubMed ID: 25533418]
McNeel DG Becker JT Eickhoff JC Johnson LE Bradley E Pohlkamp I Staab MJ Liu G Wilding G Olson BM .
Real-time immune monitoring to guide plasmid DNA vaccination schedule targeting prostatic acid phosphatase in patients with castration-resistant prostate cancer. Clin Cancer Res. 2014 Jul 15;20(14):3692-704
[PubMed ID: 24850844]
Wisinski KB Ledesma WM Kolesar J Wilding G Liu G Douglas J Traynor AM Albertini M Mulkerin D Bailey HH .
A phase I study to determine the maximum tolerated dose and safety of oral LR-103 (1α,24(S)Dihydroxyvitamin D2) in patients with advanced cancer. J Oncol Pharm Pract. 2014 Jul 1;
[PubMed ID: 24986793]
Mehraein-Ghomi F Kegel SJ Church DR Schmidt JS Reuter QR Saphner EL Basu HS Wilding G .
Targeting androgen receptor and JunD interaction for prevention of prostate cancer progression. Prostate. 2014 May;74(7):792-803
[PubMed ID: 24647988]
Deming DA Ninan J Bailey HH Kolesar JM Eickhoff J Reid JM Ames MM McGovern RM Alberti D Marnocha R Espinoza-Delgado I Wright J Wilding G Schelman WR .
A Phase I study of intermittently dosed vorinostat in combination with bortezomib in patients with advanced solid tumors. Invest New Drugs. 2014 Apr;32(2):323-9
[PubMed ID: 24114123]
Schelman WR Mohammed TA Traynor AM Kolesar JM Marnocha RM Eickhoff J Keppen M Alberti DB Wilding G Takebe N Liu G .
A phase I study of AT-101 with cisplatin and etoposide in patients with advanced solid tumors with an expanded cohort in extensive-stage small cell lung cancer. Invest New Drugs. 2014 Apr;32(2):295-302
[PubMed ID: 23860642]
Lang JM Wallace M Becker JT Eickhoff JC Buehring B Binkley N Staab MJ Wilding G Liu G Malkovsky M McNeel DG .
A randomized phase II trial evaluating different schedules of zoledronic acid on bone mineral density in patients with prostate cancer beginning androgen deprivation therapy. Clin Genitourin Cancer. 2013 Dec;11(4):407-15
[PubMed ID: 23835291]
Schelman WR Traynor AM Holen KD Kolesar JM Attia S Hoang T Eickhoff J Jiang Z Alberti D Marnocha R Reid JM Ames MM McGovern RM Espinoza-Delgado I Wright JJ Wilding G Bailey HH .
A phase I study of vorinostat in combination with bortezomib in patients with advanced malignancies. Invest New Drugs. 2013 Dec;31(6):1539-46
[PubMed ID: 24114121]
Kolesar JM Traynor AM Holen KD Hoang T Seo S Kim K Alberti D Espinoza-Delgado I Wright JJ Wilding G Bailey HH Schelman WR .
Vorinostat in combination with bortezomib in patients with advanced malignancies directly alters transcription of target genes. Cancer Chemother Pharmacol. 2013 Sep;72(3):661-7
[PubMed ID: 23903894]
Gee J Bailey H Kim K Kolesar J Havighurst T Tutsch KD See W Cohen MB Street N Levan L Jarrard D Wilding G .
Phase II open label, multi-center clinical trial of modulation of intermediate endpoint biomarkers by 1α-hydroxyvitamin D2 in patients with clinically localized prostate cancer and high grade pin. Prostate. 2013 Jun;73(9):970-8
[PubMed ID: 23335089]
Cetnar J Wilding G McNeel D LoConte NK McFarland TA Eickhoff J Liu G .
A phase 1/1b study of satraplatin (JM-216) in combination with docetaxel in patients with advanced solid tumors and metastatic castrate-resistant prostate cancer. Urol Oncol. 2013 May;31(4):436-41
[PubMed ID: 21481618]
Liu G Chen YH Kolesar J Huang W Dipaola R Pins M Carducci M Stein M Bubley GJ Wilding G .
Eastern Cooperative Oncology Group Phase II Trial of lapatinib in men with biochemically relapsed, androgen dependent prostate cancer. Urol Oncol. 2013 Feb;31(2):211-8
[PubMed ID: 21784672]
McNeel DG Smith HA Eickhoff JC Lang JM Staab MJ Wilding G Liu G .
Phase I trial of tremelimumab in combination with short-term androgen deprivation in patients with PSA-recurrent prostate cancer. Cancer Immunol Immunother. 2012 Jul;61(7):1137-47
[PubMed ID: 22210552]
Liu G Chen YH Dipaola R Carducci M Wilding G .
Phase II trial of weekly ixabepilone in men with metastatic castrate-resistant prostate cancer (E3803): a trial of the Eastern Cooperative Oncology Group. Clin Genitourin Cancer. 2012 Jun;10(2):99-105
[PubMed ID: 22386239]
Holen K DiPaola R Liu G Tan AR Wilding G Hsu K Agrawal N Chen C Xue L Rosenberg E Stein M .
A phase I trial of MK-0731, a kinesin spindle protein (KSP) inhibitor, in patients with solid tumors. Invest New Drugs. 2012 Jun;30(3):1088-95
[PubMed ID: 21424701]
Tevaarwerk A Wilding G Eickhoff J Chappell R Sidor C Arnott J Bailey H Schelman W Liu G .
Phase I study of continuous MKC-1 in patients with advanced or metastatic solid malignancies using the modified Time-to-Event Continual Reassessment Method (TITE-CRM) dose escalation design. Invest New Drugs. 2012 Jun;30(3):1039-45
[PubMed ID: 21225315]
Bruce JY Eickhoff J Pili R Logan T Carducci M Arnott J Treston A Wilding G Liu G .
A phase II study of 2-methoxyestradiol nanocrystal colloidal dispersion alone and in combination with sunitinib malate in patients with metastatic renal cell carcinoma progressing on sunitinib malate. Invest New Drugs. 2012 Apr;30(2):794-802
[PubMed ID: 21174224]