David R. Andes, MD Print Friendly Page
Faculty, University of Wisconsin School of Medicine and Public HealthDr. Andes’ clinical interests include general infectious diseases, transplant infectious diseases, mycology, antimicrobial pharmacokinetics and pharmacodynamics.
Specialties
UW Health Clinics
Hospital Affiliation(s)
University of Wisconsin Hospital and Clinics (primary)
Meriter Hospital, Veterans Hospital - Wm. S. Middleton Memorial (secondary)
Languages Spoken
| English |
| Medical interpreters are available to help patients communicate with hospital and clinic staff. For more information, please contact interpreter services at (608) 262-9000. |
UW School of Medicine and Public Health
| Department of Medicine |
Professional Certifications and Education
| Board Certification |
Infectious Diseases
Internal Medicine |
| Fellowship |
University of Wisconsin Hospital and Clinics, Madison, WI
|
| Residency |
University of Wisconsin Hospital and Clinics, Madison, WI
|
| Internship |
University of Wisconsin Hospital and Clinics, Madison, WI
|
| Medical School |
University of Missouri, 1992
|
Awards/Honors
Programs & Conditions
- Lyme Disease (Chronic/Confirmed)
- MRSA
| Research |
The overriding themes of our research programs are to advance our understanding of antibacterial and antifungal activity and drug resistance, and to identify new antimicrobial drug treatment strategies and drug targets. |
PubMed Articles
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Safdar N Baddley J Andes D .
Reply to oude lashof and vogelaers. Clin Infect Dis. 2013 May;56(10):1515-6
[PubMed ID: 23386636]
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Andes D .
Optimizing antifungal choice and administration. Curr Med Res Opin. 2013 Apr;29 Suppl 4:13-8
[PubMed ID: 23621589]
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Tebbets B Yu Z Stewart D Zhao LX Jiang Y Xu LH Andes D Shen B Klein B .
Identification of antifungal natural products via Saccharomyces cerevisiae bioassay: insights into macrotetrolide drug spectrum, potency and mode of action. Med Mycol. 2013 Apr;51(3):280-9
[PubMed ID: 22928922]
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Lee DG Murakami Y Andes DR Craig WA .
Inoculum effects of ceftobiprole, daptomycin, linezolid, and vancomycin with Staphylococcus aureus and Streptococcus pneumoniae at inocula of 10(5) and 10(7) CFU injected into opposite thighs of neutropenic mice. Antimicrob Agents Chemother. 2013 Mar;57(3):1434-41
[PubMed ID: 23295932]
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Palmer JM Bok JW Lee S Dagenais TR Andes DR Kontoyiannis DP Keller NP .
Loss of CclA, required for histone 3 lysine 4 methylation, decreases growth but increases secondary metabolite production in Aspergillus fumigatus. PeerJ. 2013;1:e4
[PubMed ID: 23638376]
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Lepak AJ Marchillo K Vanhecker J Andes DR .
Posaconazole pharmacodynamic target determination against wild-type and Cyp51 mutant isolates of Aspergillus fumigatus in an in vivo model of invasive pulmonary aspergillosis. Antimicrob Agents Chemother. 2013 Jan;57(1):579-85
[PubMed ID: 23147740]
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Lepak AJ Marchillo K Pichereau S Craig WA Andes DR .
Comparative pharmacodynamics of the new oxazolidinone tedizolid phosphate and linezolid in a neutropenic murine Staphylococcus aureus pneumonia model. Antimicrob Agents Chemother. 2012 Nov;56(11):5916-22
[PubMed ID: 22964254]
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Lepak A Castanheira M Diekema D Pfaller M Andes D .
Optimizing Echinocandin dosing and susceptibility breakpoint determination via in vivo pharmacodynamic evaluation against Candida glabrata with and without fks mutations. Antimicrob Agents Chemother. 2012 Nov;56(11):5875-82
[PubMed ID: 22948870]
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Peltier-Pain P Marchillo K Zhou M Andes DR Thorson JS .
Natural product disaccharide engineering through tandem glycosyltransferase catalysis reversibility and neoglycosylation. Org Lett. 2012 Oct 5;14(19):5086-9
[PubMed ID: 22984807]
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Rose WE Schulz LT Andes D Striker R Berti AD Hutson PR Shukla SK .
Addition of ceftaroline to daptomycin after emergence of daptomycin-nonsusceptible Staphylococcus aureus during therapy improves antibacterial activity. Antimicrob Agents Chemother. 2012 Oct;56(10):5296-302
[PubMed ID: 22869564]
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Andes DR Safdar N Baddley JW Playford G Reboli AC Rex JH Sobel JD Pappas PG Kullberg BJ .
Impact of treatment strategy on outcomes in patients with candidemia and other forms of invasive candidiasis: a patient-level quantitative review of randomized trials. Clin Infect Dis. 2012 Apr;54(8):1110-22
[PubMed ID: 22412055]
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Nett JE Marchillo K Andes DR .
Modeling of fungal biofilms using a rat central vein catheter. Methods Mol Biol. 2012;845:547-56
[PubMed ID: 22328403]
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Tebbets B Stewart D Lawry S Nett J Nantel A Andes D Klein BS .
Identification and characterization of antifungal compounds using a Saccharomyces cerevisiae reporter bioassay. PLoS One. 2012;7(5):e36021
[PubMed ID: 22574132]
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Taff HT Nett JE Zarnowski R Ross KM Sanchez H Cain MT Hamaker J Mitchell AP Andes DR .
A Candida biofilm-induced pathway for matrix glucan delivery: implications for drug resistance. PLoS Pathog. 2012;8(8):e1002848
[PubMed ID: 22876186]
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Nett JE Sanchez H Cain MT Ross KM Andes DR .
Interface of Candida albicans biofilm matrix-associated drug resistance and cell wall integrity regulation. Eukaryot Cell. 2011 Dec;10(12):1660-9
[PubMed ID: 21666076]
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Lepak AJ Andes DR .
Antifungal PK/PD considerations in fungal pulmonary infections. Semin Respir Crit Care Med. 2011 Dec;32(6):783-94
[PubMed ID: 22167406]
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Andes D Ambrose PG Hammel JP Van Wart SA Iyer V Reynolds DK Buell DN Kovanda LL Bhavnani SM .
Use of pharmacokinetic-pharmacodynamic analyses to optimize therapy with the systemic antifungal micafungin for invasive candidiasis or candidemia. Antimicrob Agents Chemother. 2011 May;55(5):2113-21
[PubMed ID: 21300835]
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Nett JE Cain MT Crawford K Andes DR .
Optimizing a Candida biofilm microtiter plate model for measurement of antifungal susceptibility by tetrazolium salt assay. J Clin Microbiol. 2011 Apr;49(4):1426-33
[PubMed ID: 21227984]
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Lepak A Andes D .
Fungal sepsis: optimizing antifungal therapy in the critical care setting. Crit Care Clin. 2011 Jan;27(1):123-47
[PubMed ID: 21144990]
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Nett JE Marchillo K Spiegel CA Andes DR .
Development and validation of an in vivo Candida albicans biofilm denture model. Infect Immun. 2010 Sep;78(9):3650-9
[PubMed ID: 20605982]
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Nett JE Crawford K Marchillo K Andes DR .
Role of Fks1p and matrix glucan in Candida albicans biofilm resistance to an echinocandin, pyrimidine, and polyene. Antimicrob Agents Chemother. 2010 Aug;54(8):3505-8
[PubMed ID: 20516280]
