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David R. Andes, MD

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David R. Andes, MD Print Friendly Page

Faculty, University of Wisconsin School of Medicine and Public Health

Dr. Andes’ clinical interests include general infectious diseases, transplant infectious diseases, mycology, antimicrobial pharmacokinetics and pharmacodynamics. 


Infectious Diseases

Travel Medicine

UW Health Clinics

UW Hospital and Clinics
(608) 263-0946 | (800) 323-8942 | Map
UW Hospital and Clinics
(608) 890-6167 | (800) 323-8942 | Map

Hospital Affiliation(s)

University of Wisconsin Hospital and Clinics (primary)
Veterans Hospital - Wm. S. Middleton Memorial (secondary)

UW School of Medicine and Public Health

Department of Medicine

Professional Certifications and Education

Board Certification Infectious Diseases
Fellowship University of Wisconsin Hospital and Clinics, Madison, WI
Residency University of Wisconsin Hospital and Clinics, Madison, WI
Internship University of Wisconsin Hospital and Clinics, Madison, WI
Medical School University of Missouri, 1992


Best Doctors® in America 2014

Best Doctors® in America 2013

Madison Magazine Top Docs 2012

Best Doctors® in America 2011

Medical interpreters are available to help patients communicate with hospital and clinic staff. For more information, please contact interpreter services at (608) 262-9000.

The overriding themes of our research programs are to advance our understanding of antibacterial and antifungal activity and drug resistance, and to identify new antimicrobial drug treatment strategies and drug targets.

PubMed Articles
Lepak AJ Marchillo K Andes DR . Pharmacodynamic Target Evaluation of a Novel Oral Glucan Synthase Inhibitor, SCY-078 (MK-3118), Using an In Vivo Murine Invasive Candidiasis Model. Antimicrob Agents Chemother. 2015 Feb;59(2):1265-72
[PubMed ID: 25512406]
Lepak AJ Marchillo K Craig WA Andes DR . In Vivo Pharmacokinetics and Pharmacodynamics of the Lantibiotic NAI-107 in a Neutropenic Murine Thigh Infection Model. Antimicrob Agents Chemother. 2015 Feb;59(2):1258-64
[PubMed ID: 25512404]
Nett JE Brooks EG Cabezas-Olcoz J Sanchez H Zarnowski R Marchillo K Andes DR . Rat indwelling urinary catheter model of Candida albicans biofilm infection. Infect Immun. 2014 Dec;82(12):4931-40
[PubMed ID: 25183731]
Lepak AJ Andes DR . Antifungal Pharmacokinetics and Pharmacodynamics. Cold Spring Harb Perspect Med. 2014 Nov 10;
[PubMed ID: 25384765]
Wyche TP Piotrowski JS Hou Y Braun D Deshpande R McIlwain S Ong IM Myers CL Guzei IA Westler WM Andes DR Bugni TS . Forazoline A: marine-derived polyketide with antifungal in vivo efficacy. Angew Chem Int Ed Engl. 2014 Oct 20;53(43):11583-6
[PubMed ID: 25197007]
Desai JV Mitchell AP Andes DR . Fungal biofilms, drug resistance, and recurrent infection. Cold Spring Harb Perspect Med. 2014 Oct 1;4(10)
[PubMed ID: 25274758]
Holland LM Schröder MS Turner SA Taff H Andes D Grózer Z Gácser A Ames L Haynes K Higgins DG Butler G . Comparative phenotypic analysis of the major fungal pathogens Candida parapsilosis and Candida albicans. PLoS Pathog. 2014 Sep;10(9):e1004365
[PubMed ID: 25233198]
Zarnowski R Westler WM Lacmbouh GA Marita JM Bothe JR Bernhardt J Lounes-Hadj Sahraoui A Fontaine J Sanchez H Hatfield RD Ntambi JM Nett JE Mitchell AP Andes DR . Novel entries in a fungal biofilm matrix encyclopedia. MBio. 2014 Aug 5;5(4):e01333-14
[PubMed ID: 25096878]
Nobile CJ Fox EP Hartooni N Mitchell KF Hnisz D Andes DR Kuchler K Johnson AD . A histone deacetylase complex mediates biofilm dispersal and drug resistance in Candida albicans. MBio. 2014 Jun 10;5(3):e01201-14
[PubMed ID: 24917598]
Sidoryk K Jaromin A Edward JA Świtalska M Stefańska J Cmoch P Zagrodzka J Szczepek W Peczyńska-Czoch W Wietrzyk J Kozubek A Zarnowski R Andes DR Kaczmarek Ł . Searching for new derivatives of neocryptolepine: synthesis, antiproliferative, antimicrobial and antifungal activities. Eur J Med Chem. 2014 May 6;78:304-13
[PubMed ID: 24686017]
Ng JK Schulz LT Rose WE Fox BC Andes DR Buhr KA Fish JT . Daptomycin dosing based on ideal body weight versus actual body weight: comparison of clinical outcomes. Antimicrob Agents Chemother. 2014;58(1):88-93
[PubMed ID: 24145531]
Pfaller MA Andes DR Diekema DJ Horn DL Reboli AC Rotstein C Franks B Azie NE . Epidemiology and outcomes of invasive candidiasis due to non-albicans species of Candida in 2,496 patients: data from the Prospective Antifungal Therapy (PATH) registry 2004-2008. PLoS One. 2014;9(7):e101510
[PubMed ID: 24991967]
Lepak AJ Marchillo K Vanhecker J Andes DR . Isavuconazole (BAL4815) pharmacodynamic target determination in an in vivo murine model of invasive pulmonary aspergillosis against wild-type and cyp51 mutant isolates of Aspergillus fumigatus. Antimicrob Agents Chemother. 2013 Dec;57(12):6284-9
[PubMed ID: 24100500]
Andes D Casadevall A . Insights into fungal pathogenesis from the iatrogenic epidemic of Exserohilum rostratum fungal meningitis. Fungal Genet Biol. 2013 Dec;61:143-5
[PubMed ID: 24012946]
Lepak AJ Marchillo K VanHecker J Diekema D Andes DR . Isavuconazole pharmacodynamic target determination for Candida species in an in vivo murine disseminated candidiasis model. Antimicrob Agents Chemother. 2013 Nov;57(11):5642-8
[PubMed ID: 24002092]
Lepak AJ Marchillo K VanHecker J Andes DR . Impact of in vivo triazole and echinocandin combination therapy for invasive pulmonary aspergillosis: enhanced efficacy against Cyp51 mutant isolates. Antimicrob Agents Chemother. 2013 Nov;57(11):5438-47
[PubMed ID: 23959322]
Andes DR Reynolds DK Van Wart SA Lepak AJ Kovanda LL Bhavnani SM . Clinical pharmacodynamic index identification for micafungin in esophageal candidiasis: dosing strategy optimization. Antimicrob Agents Chemother. 2013 Nov;57(11):5714-6
[PubMed ID: 23959319]
Taff HT Mitchell KF Edward JA Andes DR . Mechanisms of Candida biofilm drug resistance. Future Microbiol. 2013 Oct;8(10):1325-37
[PubMed ID: 24059922]
Andes D . Optimizing antifungal choice and administration. Curr Med Res Opin. 2013 Apr;29 Suppl 4:13-8
[PubMed ID: 23621589]
Tebbets B Yu Z Stewart D Zhao LX Jiang Y Xu LH Andes D Shen B Klein B . Identification of antifungal natural products via Saccharomyces cerevisiae bioassay: insights into macrotetrolide drug spectrum, potency and mode of action. Med Mycol. 2013 Apr;51(3):280-9
[PubMed ID: 22928922]