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Dai Yamanouchi, MD, PhD Print Friendly Page

Faculty, University of Wisconsin School of Medicine and Public Health

Dr. Yamanouchi is certified by the Japanese Board of Surgery and is a board certified Fellow of the Japanese College of Angiology. His expertise includes treatments for aortic aneurysms, carotid disease, aortic dissection, peripheral arterial disease and other vascular disorders.

Specialties

Vascular Surgery

UW Health Clinics

Stoughton Clinic
(608) 877-2660 | Map
1 S. Park Clinic
(608) 287-2100 | (888) 703-2778 | Map
West Clinic
(608) 263-8915 | (800) 323-8942 | Map

Hospital Affiliation(s)

University of Wisconsin Hospital and Clinics (primary)
Meriter Hospital (secondary)

Languages Spoken

English, Japanese
Medical interpreters are available to help patients communicate with hospital and clinic staff. For more information, please contact interpreter services at (608) 262-9000.

UW School of Medicine and Public Health

Department of Surgery

Professional Certifications and Education

Board Certification Surgery
Fellowship

Vascular Surgery, Division of Vascular Surgery, Department of Surgery, Nagoya University Hospital, Japan

Research Fellowship, Division of Vascular Surgery, Weill Cornell Medical College, NY

Advanced Endovascular Surgery, Division of Vascular Surgery, University of Wisconsin School of Medicine and Public Health, WI
Residency Gunma University Hospital, Japan
Saiseikai Maebashi Hospital, Japan
Internship Gunma University Hospital, Japan
Medical School Gunma University School of Medicine, Japan, 2000

Procedures

Our doctors provide a wide range of services. The following list represents some, but not all, of the procedures offered by this physician.

Programs & Conditions

Research

Dr. Yamanouchi's research interests include the pathogenesis of abdominal aortic aneurysm and restenosis after angioplasty, including balloon angioplasty and stenting. He is also devoted to the development of novel materials for vascular bypass graft and gene delivery methods to treat patients who suffer from peripheral arterial disease.

PubMed Articles
Matsumura JS Yamanouchi D Goldstein JA Pollock CW Bosiers M Schultz GA Scheinert D Rocha-Singh KJ . The United States StuDy for EvalUating EndovasculaR TreAtments of Lesions in the Superficial Femoral Artery and Proximal Popliteal By usIng the Protégé EverfLex NitInol STent SYstem II (DURABILITY II). J Vasc Surg. 2013 May 1;
[PubMed ID: 23642924]
Morgan S Yamanouchi D Harberg C Wang Q Keller M Si Y Burlingham W Seedial S Lengfeld J Liu B . Elevated protein kinase C-δ contributes to aneurysm pathogenesis through stimulation of apoptosis and inflammatory signaling. Arterioscler Thromb Vasc Biol. 2012 Oct;32(10):2493-502
[PubMed ID: 22879584]
Yamanouchi D Morgan S Stair C Seedial S Lengfeld J Kent KC Liu B . Accelerated aneurysmal dilation associated with apoptosis and inflammation in a newly developed calcium phosphate rodent abdominal aortic aneurysm model. J Vasc Surg. 2012 Aug;56(2):455-61
[PubMed ID: 22560311]
Suwanabol PA Seedial SM Shi X Zhang F Yamanouchi D Roenneburg D Liu B Kent KC . Transforming growth factor-β increases vascular smooth muscle cell proliferation through the Smad3 and extracellular signal-regulated kinase mitogen-activated protein kinases pathways. J Vasc Surg. 2012 Aug;56(2):446-54
[PubMed ID: 22521802]
Matsumura JS Gray W Chaturvedi S Yamanouchi D Peng L Verta P . Results of carotid artery stenting with distal embolic protection with improved systems: Protected Carotid Artery Stenting in Patients at High Risk for Carotid Endarterectomy (PROTECT) trial. J Vasc Surg. 2012 Apr;55(4):968-976.e5
[PubMed ID: 22236885]
Yamanouchi D Takei Y Komori K . Balanced mineralization in the arterial system: possible role of osteoclastogenesis/osteoblastogenesis in abdominal aortic aneurysm and stenotic disease. Circ J. 2012;76(12):2732-7
[PubMed ID: 23117745]
Zhang F Banker G Liu X Suwanabol PA Lengfeld J Yamanouchi D Kent KC Liu B . The novel function of advanced glycation end products in regulation of MMP-9 production. J Surg Res. 2011 Dec;171(2):871-6
[PubMed ID: 20638679]
Saurer EM Yamanouchi D Liu B Lynn DM . Delivery of plasmid DNA to vascular tissue in vivo using catheter balloons coated with polyelectrolyte multilayers. Biomaterials. 2011 Jan;32(2):610-8
[PubMed ID: 20933275]
Yamanouchi D Komori K . Eicosapentaenoic acid as the gold standard for patients with peripheral artery disease? - subanalysis of the JELIS trial -. Circ J. 2010 Jul;74(7):1298-9
[PubMed ID: 20558888]
Yamanouchi D Morgan S Kato K Lengfeld J Zhang F Liu B . Effects of caspase inhibitor on angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. 2010 Apr;30(4):702-7
[PubMed ID: 20075419]
Yamanouchi D Kato K Ryer EJ Zhang F Liu B . Protein kinase C delta mediates arterial injury responses through regulation of vascular smooth muscle cell apoptosis. Cardiovasc Res. 2010 Feb 1;85(3):434-43
[PubMed ID: 19808702]
Kato K Yamanouchi D Esbona K Kamiya K Zhang F Kent KC Liu B . Caspase-mediated protein kinase C-delta cleavage is necessary for apoptosis of vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. 2009 Dec;297(6):H2253-61
[PubMed ID: 19837952]
Kundi R Hollenbeck ST Yamanouchi D Herman BC Edlin R Ryer EJ Wang C Tsai S Liu B Kent KC . Arterial gene transfer of the TGF-beta signalling protein Smad3 induces adaptive remodelling following angioplasty: a role for CTGF. Cardiovasc Res. 2009 Nov 1;84(2):326-35
[PubMed ID: 19570811]
Zhang F Kent KC Yamanouchi D Zhang Y Kato K Tsai S Nowygrod R Schmidt AM Liu B . Anti-receptor for advanced glycation end products therapies as novel treatment for abdominal aortic aneurysm. Ann Surg. 2009 Sep;250(3):416-23
[PubMed ID: 19652591]
Tsai S Hollenbeck ST Ryer EJ Edlin R Yamanouchi D Kundi R Wang C Liu B Kent KC . TGF-beta through Smad3 signaling stimulates vascular smooth muscle cell proliferation and neointimal formation. Am J Physiol Heart Circ Physiol. 2009 Aug;297(2):H540-9
[PubMed ID: 19525370]
Zhang F Tsai S Kato K Yamanouchi D Wang C Rafii S Liu B Kent KC . Transforming growth factor-beta promotes recruitment of bone marrow cells and bone marrow-derived mesenchymal stem cells through stimulation of MCP-1 production in vascular smooth muscle cells. J Biol Chem. 2009 Jun 26;284(26):17564-74
[PubMed ID: 19406748]
Edlin RS Tsai S Yamanouchi D Wang C Liu B Kent KC . Characterization of primary and restenotic atherosclerotic plaque from the superficial femoral artery: Potential role of Smad3 in regulation of SMC proliferation. J Vasc Surg. 2009 May;49(5):1289-95
[PubMed ID: 19394554]
Kodama A Komori K Hattori K Yamanouchi D Kajikuri J Itoh T . Sarpogrelate hydrochloride reduced intimal hyperplasia in experimental rabbit vein graft. J Vasc Surg. 2009 May;49(5):1272-81
[PubMed ID: 19233592]
Sugimoto M Yamanouchi D Komori K . Therapeutic approach against intimal hyperplasia of vein grafts through endothelial nitric oxide synthase/nitric oxide (eNOS/NO) and the Rho/Rho-kinase pathway. Surg Today. 2009;39(6):459-65
[PubMed ID: 19468800]
Yamanouchi D Wu J Lazar AN Kent KC Chu CC Liu B . Biodegradable arginine-based poly(ester-amide)s as non-viral gene delivery reagents. Biomaterials. 2008 Aug;29(22):3269-77
[PubMed ID: 18456321]
Fujita H Banno H Yamanouchi D Kobayashi M Yamamoto K Komori K . Pitavastatin inhibits intimal hyperplasia in rabbit vein graft. J Surg Res. 2008 Aug;148(2):238-43
[PubMed ID: 18395752]