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Bruce S. Klein, MD

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Bruce S. Klein, MD Print Friendly Page

Faculty, University of Wisconsin School of Medicine and Public Health

Dr. Klein is a Professor in the Department of Pediatrics, Internal Medicine, and Medical Microbiology and Immunology, at the University of Wisconsin School of Medicine and Public Health. He maintains a special research and clinical interest in systemic fungal infections and has pioneered efforts in molecular pathogenesis and immunology that have helped transform the discipline into a vibrant field of research. He has published more than 100 original articles, reviews and book chapters on this subject and is a world leader in this field.


Dr. Klein has served on a number of local, national and international committees, including as Chair of the University of Wisconsin-Madison Biological Sciences Divisional Committee for Tenure and Promotion and as a Charter or Ad Hoc member of several NIH study sections. He has served on the Medical School's NIH K30 Training Grant Advisory Board and the Research Advisory Committee in Pediatrics.


Pediatric Infectious Diseases

UW Health Clinics

University Hospital
(608) 263-0946 | (800) 323-8942 | Map

Hospital Affiliation(s)

American Family Children's Hospital (primary)
Meriter Hospital (secondary)

UW School of Medicine and Public Health

Department of Pediatrics

Professional Certifications and Education

Fellowship University of Wisconsin Hospital and Clinics, Madison, WI
Residency Johns Hopkins Hospital, Baltimore, MD
Internship Johns Hopkins Hospital, Baltimore, MD
Medical School Boston University School of Medicine, Boston, MA, 1978


Best Doctors® in America 2014

Best Doctors® in America 2013

Best Doctors® in America 2011

Medical interpreters are available to help patients communicate with hospital and clinic staff. For more information, please contact interpreter services at (608) 262-9000.

Dr. Klein received several career development awards from the NIH: a Physician Scientist Award, a First Award, and a Research Career Development Award. He is funded with several active NIH grants. He received one of NIH’s most coveted honors, a MERIT award, which provides 10 years of continuous funding to the most outstanding and productive NIH funded investigators. Dr. Klein was awarded the UW-Madison Hilldale Award in Biological Sciences by the University for his distinguished research achievements. He was elected Vice Chair (2012) and Chairman (2014) at the Inaugural Gordon Research Conference on Immunology of Fungal Diseases. He has been inducted into the Association of American Physicians, a national society of physician-scientist leaders.

PubMed Articles
Muñoz JF Gauthier GM Desjardins CA Gallo JE Holder J Sullivan TD Marty AJ Carmen JC Chen Z Ding L Gujja S Magrini V Misas E Mitreva M Priest M Saif S Whiston EA Young S Zeng Q Goldman WE Mardis ER Taylor JW McEwen JG Clay OK Klein BS Cuomo CA . The Dynamic Genome and Transcriptome of the Human Fungal Pathogen Blastomyces and Close Relative Emmonsia. PLoS Genet. 2015 Oct;11(10):e1005493
[PubMed ID: 26439490]
Beaussart A Brandhorst T Dufrêne YF Klein BS . Blastomyces Virulence Adhesin-1 Protein Binding to Glycosaminoglycans Is Enhanced by Protein Disulfide Isomerase. MBio. 2015 Sep 22;6(5):e01403-15
[PubMed ID: 26396244]
Wüthrich M Wang H Li M Lerksuthirat T Hardison SE Brown GD Klein B . Fonsecaea pedrosoi-induced Th17-cell differentiation in mice is fostered by Dectin-2 and suppressed by Mincle recognition. Eur J Immunol. 2015 Sep;45(9):2542-52
[PubMed ID: 26140582]
Nanjappa SG Hernández-Santos N Galles K Wüthrich M Suresh M Klein BS . Intrinsic MyD88-Akt1-mTOR Signaling Coordinates Disparate Tc17 and Tc1 Responses during Vaccine Immunity against Fungal Pneumonia. PLoS Pathog. 2015 Sep;11(9):e1005161
[PubMed ID: 26367276]
Wüthrich M Brandhorst TT Sullivan TD Filutowicz H Sterkel A Stewart D Li M Lerksuthirat T LeBert V Shen ZT Ostroff G Deepe GS Jr Hung CY Cole G Walter JA Jenkins MK Klein B . Calnexin induces expansion of antigen-specific CD4(+) T cells that confer immunity to fungal ascomycetes via conserved epitopes. Cell Host Microbe. 2015 Apr 8;17(4):452-65
[PubMed ID: 25800545]
Sterkel AK Mettelman R Wüthrich M Klein BS . The unappreciated intracellular lifestyle of Blastomyces dermatitidis. J Immunol. 2015 Feb 15;194(4):1796-805
[PubMed ID: 25589071]
Verma A Wüthrich M Deepe G Klein B . Adaptive immunity to fungi. Cold Spring Harb Perspect Med. 2014 Nov 6;5(3):a019612
[PubMed ID: 25377140]
Nanjappa SG Klein BS . Vaccine immunity against fungal infections. Curr Opin Immunol. 2014 Jun;28:27-33
[PubMed ID: 24583636]
Wang H LeBert V Hung CY Galles K Saijo S Lin X Cole GT Klein BS Wüthrich M . C-type lectin receptors differentially induce th17 cells and vaccine immunity to the endemic mycosis of North America. J Immunol. 2014 Feb 1;192(3):1107-19
[PubMed ID: 24391211]
Wüthrich M LeBert V Galles K Hu-Li J Ben-Sasson SZ Paul WE Klein BS . Interleukin 1 enhances vaccine-induced antifungal T-helper 17 cells and resistance against Blastomyces dermatitidis infection. J Infect Dis. 2013 Oct 1;208(7):1175-82
[PubMed ID: 23788728]
Roy RM Klein BS . Fungal glycan interactions with epithelial cells in allergic airway disease. Curr Opin Microbiol. 2013 Aug;16(4):404-8
[PubMed ID: 23602359]
Marty AJ Wüthrich M Carmen JC Sullivan TD Klein BS Cuomo CA Gauthier GM . Isolation of Blastomyces dermatitidis yeast from lung tissue during murine infection for in vivo transcriptional profiling. Fungal Genet Biol. 2013 Jul;56:1-8
[PubMed ID: 23499858]
Roy RM Paes HC Nanjappa SG Sorkness R Gasper D Sterkel A Wüthrich M Klein BS . Complement component 3C3 and C3a receptor are required in chitin-dependent allergic sensitization to Aspergillus fumigatus but dispensable in chitin-induced innate allergic inflammation. MBio. 2013 Apr 2;4(2)
[PubMed ID: 23549917]
Tebbets B Yu Z Stewart D Zhao LX Jiang Y Xu LH Andes D Shen B Klein B . Identification of antifungal natural products via Saccharomyces cerevisiae bioassay: insights into macrotetrolide drug spectrum, potency and mode of action. Med Mycol. 2013 Apr;51(3):280-9
[PubMed ID: 22928922]
Cole GT Hung CY Sanderson SD Hurtgen BJ Wüthrich M Klein BS Deepe GS Ostroff GR Levitz SM . Novel strategies to enhance vaccine immunity against coccidioidomycosis. PLoS Pathog. 2013;9(12):e1003768
[PubMed ID: 24367252]
Brandhorst TT Roy R Wüthrich M Nanjappa S Filutowicz H Galles K Tonelli M McCaslin DR Satyshur K Klein B . Structure and function of a fungal adhesin that binds heparin and mimics thrombospondin-1 by blocking T cell activation and effector function. PLoS Pathog. 2013;9(7):e1003464
[PubMed ID: 23853587]
Roy RM Wüthrich M Klein BS . Chitin elicits CCL2 from airway epithelial cells and induces CCR2-dependent innate allergic inflammation in the lung. J Immunol. 2012 Sep 1;189(5):2545-52
[PubMed ID: 22851704]
Roy RM Klein BS . Dendritic cells in antifungal immunity and vaccine design. Cell Host Microbe. 2012 May 17;11(5):436-46
[PubMed ID: 22607797]
Wüthrich M Ersland K Sullivan T Galles K Klein BS . Fungi subvert vaccine T cell priming at the respiratory mucosa by preventing chemokine-induced influx of inflammatory monocytes. Immunity. 2012 Apr 20;36(4):680-92
[PubMed ID: 22483803]
Nanjappa SG Heninger E Wüthrich M Sullivan T Klein B . Protective antifungal memory CD8(+) T cells are maintained in the absence of CD4(+) T cell help and cognate antigen in mice. J Clin Invest. 2012 Mar;122(3):987-99
[PubMed ID: 22354169]