Bruce S. Klein, MD Print Friendly PageFaculty, University of Wisconsin School of Medicine and Public Health
Dr. Klein is a Professor in the Department of Pediatrics, Internal Medicine, and Medical Microbiology and Immunology, at the University of Wisconsin School of Medicine and Public Health. He maintains a special research and clinical interest in systemic fungal infections and has pioneered efforts in molecular pathogenesis and immunology that have helped transform the discipline into a vibrant field of research. He has published more than 100 original articles, reviews and book chapters on this subject and is a world leader in this field.
Dr. Klein has served on a number of local, national and international committees, including as Chair of the University of Wisconsin-Madison Biological Sciences Divisional Committee for Tenure and Promotion and as a Charter or Ad Hoc member of several NIH study sections. He has served on the Medical School's NIH K30 Training Grant Advisory Board and the Research Advisory Committee in Pediatrics.
UW Health Clinics
UW School of Medicine and Public Health
|Department of Pediatrics|
Professional Certifications and Education
University of Wisconsin Hospital and Clinics, Madison, WI
The The Johns Hopkins Hospital, Baltimore, MD
The The Johns Hopkins Hospital, Baltimore, MD
Boston University School of Medicine, Boston, MA, 1978
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Dr. Klein received several career development awards from the NIH: a Physician Scientist Award, a First Award, and a Research Career Development Award. He is funded with several active NIH grants. He received one of NIH’s most coveted honors, a MERIT award, which provides 10 years of continuous funding to the most outstanding and productive NIH funded investigators. Dr. Klein was awarded the UW-Madison Hilldale Award in Biological Sciences by the University for his distinguished research achievements. He was elected Vice Chair (2012) and Chairman (2014) at the Inaugural Gordon Research Conference on Immunology of Fungal Diseases. He has been inducted into the Association of American Physicians, a national society of physician-scientist leaders.
Lawry SM Tebbets B Kean I Stewart D Hetelle J Klein BS .
Fludioxonil Induces Drk1, a Fungal Group III Hybrid Histidine Kinase, To Dephosphorylate Its Downstream Target, Ypd1. Antimicrob Agents Chemother. 2017 Feb;61(2)
[PubMed ID: 27872062]
Xu X Pocock GM Sharma A Peery SL Fites JS Felley L Zarnowski R Stewart D Berthier E Klein BS Sherer NM Gumperz JE .
Human iNKT Cells Promote Protective Inflammation by Inducing Oscillating Purinergic Signaling in Monocyte-Derived DCs. Cell Rep. 2016 Sep 20;16(12):3273-85
[PubMed ID: 27653689]
Wang H Li M Hung CY Sinha M Lee LM Wiesner DL LeBert V Lerksuthirat T Galles K Suresh M DeFranco AL Lowell CA Klein BS Wüthrich M .
MyD88 Shapes Vaccine Immunity by Extrinsically Regulating Survival of CD4+ T Cells during the Contraction Phase. PLoS Pathog. 2016 Aug 19;12(8):e1005787
[PubMed ID: 27542117]
Xiong Y Lingrel JB Wüthrich M Klein BS Vasudevan NT Jain MK George M Deepe GS Jr .
Transcription Factor KLF2 in Dendritic Cells Downregulates Th2 Programming via the HIF-1α/Jagged2/Notch Axis. MBio. 2016 Jun 14;7(3)
[PubMed ID: 27302755]
Wang H LeBert V Li M Lerksuthirat T Galles K Klein B Wüthrich M .
Mannose Receptor Is Required for Optimal Induction of Vaccine-Induced T-Helper Type 17 Cells and Resistance to Blastomyces dermatitidis Infection. J Infect Dis. 2016 Jun 1;213(11):1762-6
[PubMed ID: 26931447]
Garfoot AL Shen Q Wüthrich M Klein BS Rappleye CA .
The Eng1 β-Glucanase Enhances Histoplasma Virulence by Reducing β-Glucan Exposure. MBio. 2016 Apr 19;7(2):e01388-15
[PubMed ID: 27094334]
Sterkel AK Lorenzini JL Fites JS Subramanian Vignesh K Sullivan TD Wuthrich M Brandhorst T Hernandez-Santos N Deepe GS Jr Klein BS .
Fungal Mimicry of a Mammalian Aminopeptidase Disables Innate Immunity and Promotes Pathogenicity. Cell Host Microbe. 2016 Mar 9;19(3):361-74
[PubMed ID: 26922990]
Wang H Li M Lerksuthirat T Klein B Wüthrich M .
The C-Type Lectin Receptor MCL Mediates Vaccine-Induced Immunity against Infection with Blastomyces dermatitidis. Infect Immun. 2015 Dec 14;84(3):635-42
[PubMed ID: 26667836]
Muñoz JF Gauthier GM Desjardins CA Gallo JE Holder J Sullivan TD Marty AJ Carmen JC Chen Z Ding L Gujja S Magrini V Misas E Mitreva M Priest M Saif S Whiston EA Young S Zeng Q Goldman WE Mardis ER Taylor JW McEwen JG Clay OK Klein BS Cuomo CA .
The Dynamic Genome and Transcriptome of the Human Fungal Pathogen Blastomyces and Close Relative Emmonsia. PLoS Genet. 2015 Oct 6;11(10):e1005493
[PubMed ID: 26439490]
Beaussart A Brandhorst T Dufrêne YF Klein BS .
Blastomyces Virulence Adhesin-1 Protein Binding to Glycosaminoglycans Is Enhanced by Protein Disulfide Isomerase. MBio. 2015 Sep 22;6(5):e01403-15
[PubMed ID: 26396244]
Nanjappa SG Hernández-Santos N Galles K Wüthrich M Suresh M Klein BS .
Intrinsic MyD88-Akt1-mTOR Signaling Coordinates Disparate Tc17 and Tc1 Responses during Vaccine Immunity against Fungal Pneumonia. PLoS Pathog. 2015 Sep 14;11(9):e1005161
[PubMed ID: 26367276]
Wüthrich M Wang H Li M Lerksuthirat T Hardison SE Brown GD Klein B .
Fonsecaea pedrosoi-induced Th17-cell differentiation in mice is fostered by Dectin-2 and suppressed by Mincle recognition. Eur J Immunol. 2015 Sep;45(9):2542-52
[PubMed ID: 26140582]
Wüthrich M Brandhorst TT Sullivan TD Filutowicz H Sterkel A Stewart D Li M Lerksuthirat T LeBert V Shen ZT Ostroff G Deepe GS Jr Hung CY Cole G Walter JA Jenkins MK Klein B .
Calnexin induces expansion of antigen-specific CD4(+) T cells that confer immunity to fungal ascomycetes via conserved epitopes. Cell Host Microbe. 2015 Apr 8;17(4):452-65
[PubMed ID: 25800545]
Sterkel AK Mettelman R Wüthrich M Klein BS .
The unappreciated intracellular lifestyle of Blastomyces dermatitidis. J Immunol. 2015 Feb 15;194(4):1796-805
[PubMed ID: 25589071]
Verma A Wüthrich M Deepe G Klein B .
Adaptive immunity to fungi. Cold Spring Harb Perspect Med. 2014 Nov 6;5(3):a019612
[PubMed ID: 25377140]
Nanjappa SG Klein BS .
Vaccine immunity against fungal infections. Curr Opin Immunol. 2014 Jun;28:27-33
[PubMed ID: 24583636]
Wang H LeBert V Hung CY Galles K Saijo S Lin X Cole GT Klein BS Wüthrich M .
C-type lectin receptors differentially induce th17 cells and vaccine immunity to the endemic mycosis of North America. J Immunol. 2014 Feb 1;192(3):1107-19
[PubMed ID: 24391211]
Wüthrich M LeBert V Galles K Hu-Li J Ben-Sasson SZ Paul WE Klein BS .
Interleukin 1 enhances vaccine-induced antifungal T-helper 17 cells and resistance against Blastomyces dermatitidis infection. J Infect Dis. 2013 Oct 1;208(7):1175-82
[PubMed ID: 23788728]
Roy RM Klein BS .
Fungal glycan interactions with epithelial cells in allergic airway disease. Curr Opin Microbiol. 2013 Aug;16(4):404-8
[PubMed ID: 23602359]
Marty AJ Wüthrich M Carmen JC Sullivan TD Klein BS Cuomo CA Gauthier GM .
Isolation of Blastomyces dermatitidis yeast from lung tissue during murine infection for in vivo transcriptional profiling. Fungal Genet Biol. 2013 Jul;56:1-8
[PubMed ID: 23499858]