American Family Children's Hospital
Bruce S. Klein, MD close
Bruce S. Klein, MD

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Bruce S. Klein, MD Print Friendly Page

Faculty, University of Wisconsin School of Medicine and Public Health

Dr. Klein is a Professor in the Department of Pediatrics, Internal Medicine, and Medical Microbiology and Immunology, at the University of Wisconsin School of Medicine and Public Health. He maintains a special research and clinical interest in systemic fungal infections and has pioneered efforts in molecular pathogenesis and immunology that have helped transform the discipline into a vibrant field of research. He has published more than 100 original articles, reviews and book chapters on this subject and is a world leader in this field.


Dr. Klein has served on a number of local, national and international committees, including as Chair of the University of Wisconsin-Madison Biological Sciences Divisional Committee for Tenure and Promotion and as a Charter or Ad Hoc member of several NIH study sections. He has served on the Medical School's NIH K30 Training Grant Advisory Board and the Research Advisory Committee in Pediatrics.


Pediatric Infectious Diseases

UW Health Clinics

University Hospital
(608) 263-0946 | (800) 323-8942 | Map

Hospital Affiliation(s)

American Family Children's Hospital (primary)
UnityPoint Health - Meriter (secondary)

UW School of Medicine and Public Health

Department of Pediatrics

Professional Certifications and Education

Fellowship University of Wisconsin Hospital and Clinics, Madison, WI
Residency The The Johns Hopkins Hospital, Baltimore, MD
Internship The The Johns Hopkins Hospital, Baltimore, MD
Medical School Boston University School of Medicine, Boston, MA, 1978


Best Doctors® in America 2015

Best Doctors® in America 2014

Best Doctors® in America 2013


Medical interpreters are available to help patients communicate with hospital and clinic staff. For more information, please contact interpreter services at (608) 262-9000.

Dr. Klein received several career development awards from the NIH: a Physician Scientist Award, a First Award, and a Research Career Development Award. He is funded with several active NIH grants. He received one of NIH’s most coveted honors, a MERIT award, which provides 10 years of continuous funding to the most outstanding and productive NIH funded investigators. Dr. Klein was awarded the UW-Madison Hilldale Award in Biological Sciences by the University for his distinguished research achievements. He was elected Vice Chair (2012) and Chairman (2014) at the Inaugural Gordon Research Conference on Immunology of Fungal Diseases. He has been inducted into the Association of American Physicians, a national society of physician-scientist leaders.

PubMed Articles
Lorenzini J Scott Fites J Nett J Klein BS . Blastomyces dermatitidis serine protease dipeptidyl peptidase IVA (DppIVA) cleaves ELR+ CXC chemokines altering their effects on neutrophils. Cell Microbiol. 2017 Sep;19(9)
[PubMed ID: 28346820]
McBride JA Gauthier GM Klein BS . Clinical Manifestations and Treatment of Blastomycosis. Clin Chest Med. 2017 Sep;38(3):435-449
[PubMed ID: 28797487]
Wang H Lee TJ Fites SJ Merkhofer R Zarnowski R Brandhorst T Galles K Klein B Wüthrich M . Ligation of Dectin-2 with a novel microbial ligand promotes adjuvant activity for vaccination. PLoS Pathog. 2017 Aug 9;13(8):e1006568
[PubMed ID: 28793349]
Nanjappa SG McDermott AJ Fites JS Galles K Wüthrich M Deepe GS Jr Klein BS . Antifungal Tc17 cells are durable and stable, persisting as long-lasting vaccine memory without plasticity towards IFNγ cells. PLoS Pathog. 2017 May;13(5):e1006356
[PubMed ID: 28542595]
Wiemann P Perevitsky A Lim FY Shadkchan Y Knox BP Landero Figueora JA Choera T Niu M Steinberger AJ Wüthrich M Idol RA Klein BS Dinauer MC Huttenlocher A Osherov N Keller NP . Aspergillus fumigatus Copper Export Machinery and Reactive Oxygen Intermediate Defense Counter Host Copper-Mediated Oxidative Antimicrobial Offense. Cell Rep. 2017 May 2;19(5):1008-1021
[PubMed ID: 28467895]
Kottom TJ Hebrink DM Jenson PE Nandakumar V Wüthrich M Wang H Klein B Yamasaki S Lepenies B Limper AH . The Interaction of Pneumocystis with the C-Type Lectin Receptor Mincle Exerts a Significant Role in Host Defense against Infection. J Immunol. 2017 May 1;198(9):3515-3525
[PubMed ID: 28298521]
Walsh NM Wuthrich M Wang H Klein B Hull CM . Characterization of C-type lectins reveals an unexpectedly limited interaction between Cryptococcus neoformans spores and Dectin-1. PLoS One. 2017;12(3):e0173866
[PubMed ID: 28282442]
Lawry SM Tebbets B Kean I Stewart D Hetelle J Klein BS . Fludioxonil Induces Drk1, a Fungal Group III Hybrid Histidine Kinase, To Dephosphorylate Its Downstream Target, Ypd1. Antimicrob Agents Chemother. 2017 Feb;61(2)
[PubMed ID: 27872062]
Xu X Pocock GM Sharma A Peery SL Fites JS Felley L Zarnowski R Stewart D Berthier E Klein BS Sherer NM Gumperz JE . Human iNKT Cells Promote Protective Inflammation by Inducing Oscillating Purinergic Signaling in Monocyte-Derived DCs. Cell Rep. 2016 Sep 20;16(12):3273-85
[PubMed ID: 27653689]
Wang H Li M Hung CY Sinha M Lee LM Wiesner DL LeBert V Lerksuthirat T Galles K Suresh M DeFranco AL Lowell CA Klein BS Wüthrich M . MyD88 Shapes Vaccine Immunity by Extrinsically Regulating Survival of CD4+ T Cells during the Contraction Phase. PLoS Pathog. 2016 Aug;12(8):e1005787
[PubMed ID: 27542117]
Xiong Y Lingrel JB Wüthrich M Klein BS Vasudevan NT Jain MK George M Deepe GS Jr . Transcription Factor KLF2 in Dendritic Cells Downregulates Th2 Programming via the HIF-1α/Jagged2/Notch Axis. MBio. 2016 Jun 14;7(3)
[PubMed ID: 27302755]
Wang H LeBert V Li M Lerksuthirat T Galles K Klein B Wüthrich M . Mannose Receptor Is Required for Optimal Induction of Vaccine-Induced T-Helper Type 17 Cells and Resistance to Blastomyces dermatitidis Infection. J Infect Dis. 2016 Jun 1;213(11):1762-6
[PubMed ID: 26931447]
Garfoot AL Shen Q Wüthrich M Klein BS Rappleye CA . The Eng1 β-Glucanase Enhances Histoplasma Virulence by Reducing β-Glucan Exposure. MBio. 2016 Apr 19;7(2):e01388-15
[PubMed ID: 27094334]
Sterkel AK Lorenzini JL Fites JS Subramanian Vignesh K Sullivan TD Wuthrich M Brandhorst T Hernandez-Santos N Deepe GS Jr Klein BS . Fungal Mimicry of a Mammalian Aminopeptidase Disables Innate Immunity and Promotes Pathogenicity. Cell Host Microbe. 2016 Mar 9;19(3):361-74
[PubMed ID: 26922990]
Wang H Li M Lerksuthirat T Klein B Wüthrich M . The C-Type Lectin Receptor MCL Mediates Vaccine-Induced Immunity against Infection with Blastomyces dermatitidis. Infect Immun. 2015 Dec 14;84(3):635-42
[PubMed ID: 26667836]
Muñoz JF Gauthier GM Desjardins CA Gallo JE Holder J Sullivan TD Marty AJ Carmen JC Chen Z Ding L Gujja S Magrini V Misas E Mitreva M Priest M Saif S Whiston EA Young S Zeng Q Goldman WE Mardis ER Taylor JW McEwen JG Clay OK Klein BS Cuomo CA . The Dynamic Genome and Transcriptome of the Human Fungal Pathogen Blastomyces and Close Relative Emmonsia. PLoS Genet. 2015 Oct;11(10):e1005493
[PubMed ID: 26439490]
Beaussart A Brandhorst T Dufrêne YF Klein BS . Blastomyces Virulence Adhesin-1 Protein Binding to Glycosaminoglycans Is Enhanced by Protein Disulfide Isomerase. MBio. 2015 Sep 22;6(5):e01403-15
[PubMed ID: 26396244]
Nanjappa SG Hernández-Santos N Galles K Wüthrich M Suresh M Klein BS . Intrinsic MyD88-Akt1-mTOR Signaling Coordinates Disparate Tc17 and Tc1 Responses during Vaccine Immunity against Fungal Pneumonia. PLoS Pathog. 2015 Sep;11(9):e1005161
[PubMed ID: 26367276]
Wüthrich M Wang H Li M Lerksuthirat T Hardison SE Brown GD Klein B . Fonsecaea pedrosoi-induced Th17-cell differentiation in mice is fostered by Dectin-2 and suppressed by Mincle recognition. Eur J Immunol. 2015 Sep;45(9):2542-52
[PubMed ID: 26140582]
Wüthrich M Brandhorst TT Sullivan TD Filutowicz H Sterkel A Stewart D Li M Lerksuthirat T LeBert V Shen ZT Ostroff G Deepe GS Jr Hung CY Cole G Walter JA Jenkins MK Klein B . Calnexin induces expansion of antigen-specific CD4(+) T cells that confer immunity to fungal ascomycetes via conserved epitopes. Cell Host Microbe. 2015 Apr 8;17(4):452-65
[PubMed ID: 25800545]