Bruce S. Klein, MD Print Friendly PageFaculty, University of Wisconsin School of Medicine and Public Health
Dr. Klein maintains a special research and clinical interest in systemic fungal infections.
UW Health Clinics
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UW School of Medicine and Public Health
|Department of Pediatrics|
Professional Certifications and Education
University of Wisconsin Hospital and Clinics, Madison, WI
Johns Hopkins Hospital, Baltimore, MD
Johns Hopkins Hospital, Baltimore, MD
Boston University, 1978
Programs & Conditions
Dr. Klein holds two RO-1 NIH grants and an NIH career development award. He received one of the inaugural Burroughs-Wellcome Molecular Mycology Scholar Awards and has become one of the pre-eminent investigators worldwide on the immunopathogenesis of deep fungal infection.
Roy RM Klein BS .
Fungal glycan interactions with epithelial cells in allergic airway disease. Curr Opin Microbiol. 2013 Apr 17;
[PubMed ID: 23602359]
Roy RM Paes HC Nanjappa SG Sorkness R Gasper D Sterkel A Wüthrich M Klein BS .
Complement component 3C3 and C3a receptor are required in chitin-dependent allergic sensitization to Aspergillus fumigatus but dispensable in chitin-induced innate allergic inflammation. MBio. 2013 Apr 2;4(2)
[PubMed ID: 23549917]
Tebbets B Yu Z Stewart D Zhao LX Jiang Y Xu LH Andes D Shen B Klein B .
Identification of antifungal natural products via Saccharomyces cerevisiae bioassay: insights into macrotetrolide drug spectrum, potency and mode of action. Med Mycol. 2013 Apr;51(3):280-9
[PubMed ID: 22928922]
Marty AJ Wüthrich M Carmen JC Sullivan TD Klein BS Cuomo CA Gauthier GM .
Isolation of Blastomyces dermatitidis yeast from lung tissue during murine infection for in vivo transcriptional profiling. Fungal Genet Biol. 2013 Mar 14;
[PubMed ID: 23499858]
Roy RM Wüthrich M Klein BS .
Chitin elicits CCL2 from airway epithelial cells and induces CCR2-dependent innate allergic inflammation in the lung. J Immunol. 2012 Sep 1;189(5):2545-52
[PubMed ID: 22851704]
Roy RM Klein BS .
Dendritic cells in antifungal immunity and vaccine design. Cell Host Microbe. 2012 May 17;11(5):436-46
[PubMed ID: 22607797]
Wüthrich M Ersland K Sullivan T Galles K Klein BS .
Fungi subvert vaccine T cell priming at the respiratory mucosa by preventing chemokine-induced influx of inflammatory monocytes. Immunity. 2012 Apr 20;36(4):680-92
[PubMed ID: 22483803]
Nanjappa SG Heninger E Wüthrich M Sullivan T Klein B .
Protective antifungal memory CD8(+) T cells are maintained in the absence of CD4(+) T cell help and cognate antigen in mice. J Clin Invest. 2012 Mar 1;122(3):987-99
[PubMed ID: 22354169]
Wüthrich M Ersland K Pick-Jacobs JC Gern BH Frye CA Sullivan TD Brennan MB Filutowicz HI O'Brien K Korthauer KD Schultz-Cherry S Klein BS .
Limited model antigen expression by transgenic fungi induces disparate fates during differentiation of adoptively transferred T cell receptor transgenic CD4+ T cells: robust activation and proliferation with weak effector function during recall. Infect Immun. 2012 Feb;80(2):787-97
[PubMed ID: 22124658]
Wüthrich M Deepe GS Jr Klein B .
Adaptive immunity to fungi. Annu Rev Immunol. 2012;30:115-48
[PubMed ID: 22224780]
Tebbets B Stewart D Lawry S Nett J Nantel A Andes D Klein BS .
Identification and characterization of antifungal compounds using a Saccharomyces cerevisiae reporter bioassay. PLoS One. 2012;7(5):e36021
[PubMed ID: 22574132]
Nanjappa SG Heninger E Wüthrich M Gasper DJ Klein BS .
Tc17 cells mediate vaccine immunity against lethal fungal pneumonia in immune deficient hosts lacking CD4+ T cells. PLoS Pathog. 2012;8(7):e1002771
[PubMed ID: 22829762]
Wüthrich M Hung CY Gern BH Pick-Jacobs JC Galles KJ Filutowicz HI Cole GT Klein BS .
A TCR transgenic mouse reactive with multiple systemic dimorphic fungi. J Immunol. 2011 Aug 1;187(3):1421-31
[PubMed ID: 21705621]
Pfister JR Archer JR Hersil S Boers T Reed KD Meece JK Anderson JL Burgess JW Sullivan TD Klein BS Wheat LJ Davis JP .
Non-rural point source blastomycosis outbreak near a yard waste collection site. Clin Med Res. 2011 Jun;9(2):57-65
[PubMed ID: 20974888]
Rocco NM Carmen JC Klein BS .
Blastomyces dermatitidis yeast cells inhibit nitric oxide production by alveolar macrophage inducible nitric oxide synthase. Infect Immun. 2011 Jun;79(6):2385-95
[PubMed ID: 21444664]
Wüthrich M Krajaejun T Shearn-Bochsler V Bass C Filutowicz HI Legendre AM Klein BS .
Safety, tolerability, and immunogenicity of a recombinant, genetically engineered, live-attenuated vaccine against canine blastomycosis. Clin Vaccine Immunol. 2011 May;18(5):783-9
[PubMed ID: 21367980]
Wüthrich M Gern B Hung CY Ersland K Rocco N Pick-Jacobs J Galles K Filutowicz H Warner T Evans M Cole G Klein B .
Vaccine-induced protection against 3 systemic mycoses endemic to North America requires Th17 cells in mice. J Clin Invest. 2011 Feb;121(2):554-68
[PubMed ID: 21206087]
Poulsen M Cafaro MJ Erhardt DP Little AE Gerardo NM Tebbets B Klein BS Currie CR .
Variation in Pseudonocardia antibiotic defence helps govern parasite-induced morbidity in Acromyrmex leaf-cutting ants. Environ Microbiol Rep. 2010 Aug;2(4):534-540
[PubMed ID: 22896766]
Ersland K Wüthrich M Klein BS .
Dynamic interplay among monocyte-derived, dermal, and resident lymph node dendritic cells during the generation of vaccine immunity to fungi. Cell Host Microbe. 2010 Jun 25;7(6):474-87
[PubMed ID: 20542251]
Krajaejun T Wüthrich M Gauthier GM Warner TF Sullivan TD Klein BS .
Discordant influence of Blastomyces dermatitidis yeast-phase-specific gene BYS1 on morphogenesis and virulence. Infect Immun. 2010 Jun;78(6):2522-8
[PubMed ID: 20368350]
Gauthier GM Sullivan TD Gallardo SS Brandhorst TT Vanden Wymelenberg AJ Cuomo CA Suen G Currie CR Klein BS .
SREB, a GATA transcription factor that directs disparate fates in Blastomyces dermatitidis including morphogenesis and siderophore biosynthesis. PLoS Pathog. 2010 Apr 1;6(4):e1000846
[PubMed ID: 20368971]