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Barbara E.K. Klein, MD, MPH

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Barbara E.K. Klein, MD, MPH Print Friendly Page

Faculty, University of Wisconsin School of Medicine and Public Health

Dr. Klein is co-director of the Beaver Dam Eye Study, which collects information on the prevalence and incidence of age-related cataract, macular degeneration,and diabetic retinopathy, which are all common eye diseases in an aging population. The study also has examined other aging issues, such as overall health, quality-of-life and environmental and medicinal exposures.


Eye Care Services (Ophthalmology)

UW Health Clinics

University Station Clinic
(608) 263-7171 | (800) 323-8942 | Map

Hospital Affiliation(s)

University of Wisconsin Hospital and Clinics (primary)
Veterans Hospital - Wm. S. Middleton Memorial (secondary)

UW School of Medicine and Public Health

Department of Ophthalmology and Visual Sciences

Professional Certifications and Education

Board Certification Ophthalmology
Preventive Medicine
Fellowship University of Wisconsin Hospital and Clinics, Madison, WI
Residency University of Wisconsin Hospital and Clinics, Madison, WI
Internship Bellevue Hospital, New York, NY
New York University Medical Center, New York, NY
Medical School New York University, New York, NY, 1969

Medical interpreters are available to help patients communicate with hospital and clinic staff. For more information, please contact interpreter services at (608) 262-9000.

Programs & Conditions

PubMed Articles
Ratnapriya R Zhan X Fariss RN Branham KE Zipprer D Chakarova CF Sergeev YV Campos MM Othman M Friedman JS Maminishkis A Waseem NH Brooks M Rajasimha HK Edwards AO Lotery A Klein BE Truitt BJ Li B Schaumberg DA Morgan DJ Morrison MA Souied E Tsironi EE Grassmann F Fishman GA Silvestri G Scholl HP Kim IK Ramke J Tuo J Merriam JE Merriam JC Park KH Olson LM Farrer LA Johnson MP Peachey NS Lathrop M Baron RV Igo RP Jr Klein R Hagstrom SA Kamatani Y Martin TM Jiang Y Conley Y Sahel JA Zack DJ Chan CC Pericak-Vance MA Jacobson SG Gorin MB Klein ML Allikmets R Iyengar SK Weber BH Haines JL Léveillard T Deangelis MM Stambolian D Weeks DE Bhattacharya SS Chew EY Heckenlively JR Abecasis GR Swaroop A . Rare and common variants in extracellular matrix gene Fibrillin 2 (FBN2) are associated with macular degeneration. Hum Mol Genet. 2014 Nov 1;23(21):5827-37
[PubMed ID: 24899048]
Myers CE Klein BE Gangnon R Sivakumaran TA Iyengar SK Klein R . Cigarette smoking and the natural history of age-related macular degeneration: the beaver dam eye study. Ophthalmology. 2014 Oct;121(10):1949-55
[PubMed ID: 24953792]
Restrepo NA Spencer KM Goodloe R Garrett TA Heiss G Bůžková P Jorgensen N Jensen RA Matise TC Hindorff LA Klein BE Klein R Wong TY Cheng CY Cornes BK Tai ES Ritchie MD Haines J Crawford DC . Genetic determinants of age-related macular degeneration in diverse populations from the PAGE Study. Invest Ophthalmol Vis Sci. 2014 Sep 9;
[PubMed ID: 25205864]
Klein R Myers CE Buitendijk GH Rochtchina E Gao X de Jong PT Sivakumaran TA Burlutsky G McKean-Cowdin R Hofman A Iyengar SK Lee KE Stricker BH Vingerling JR Mitchell P Klein BE Klaver CC Wang JJ . Lipids, lipid genes, and incident age-related macular degeneration: the three continent age-related macular degeneration consortium. Am J Ophthalmol. 2014 Sep;158(3):513-24.e3
[PubMed ID: 24879949]
Wichmann MA Cruickshanks KJ Carlsson CM Chappell R Fischer ME Klein BE Klein R Tsai MY Schubert CR . Long-term systemic inflammation and cognitive impairment in a population-based cohort. J Am Geriatr Soc. 2014 Sep;62(9):1683-91
[PubMed ID: 25123210]
Sabour-Pickett S Beatty S Connolly E Loughman J Stack J Howard A Klein R Klein BE Meuer SM Myers CE Akuffo KO Nolan JM . Supplementation with three different macular carotenoid formulations in patients with early age-related macular degeneration. Retina. 2014 Sep;34(9):1757-66
[PubMed ID: 24887490]
Klein BE Howard KP Iyengar SK Sivakumaran TA Meyers KJ Cruickshanks KJ Klein R . Sunlight exposure, pigmentation, and incident age-related macular degeneration. Invest Ophthalmol Vis Sci. 2014 Aug 14;55(9):5855-61
[PubMed ID: 25125603]
Klein R Myers CE Klein BE . Vasodilators, blood pressure-lowering medications, and age-related macular degeneration: the Beaver Dam Eye Study. Ophthalmology. 2014 Aug;121(8):1604-11
[PubMed ID: 24793737]
Chong EW Guymer RH Klein R Klein BE Cotch MF Wang JJ Shlipak MG Wong TY . Is renal function associated with early age-related macular degeneration? Optom Vis Sci. 2014 Aug;91(8):860-4
[PubMed ID: 24879085]
Chiu CJ Mitchell P Klein R Klein BE Chang ML Gensler G Taylor A . A risk score for the prediction of advanced age-related macular degeneration: development and validation in 2 prospective cohorts. Ophthalmology. 2014 Jul;121(7):1421-7
[PubMed ID: 24650555]
Liao J Su X Chen P Wang X Xu L Li X Thean L Tan C Tan AG Tay WT Jun G Zheng Y Chew M Wang YX Tan QS Barathi VA Klein BE Saw SM Vithana EN Tai ES Iyengar SK Mitchell P Khor CC Aung T Wang JJ Jonas JB Teo YY Wong TY Cheng CY . Meta-analysis of genome-wide association studies in multiethnic Asians identifies two loci for age-related nuclear cataract. Hum Mol Genet. 2014 Jun 20;
[PubMed ID: 24951543]
Klein R Lee KE Gangnon RE Klein BE . Relation of smoking, drinking, and physical activity to changes in vision over a 20-year period: the Beaver Dam Eye Study. Ophthalmology. 2014 Jun;121(6):1220-8
[PubMed ID: 24594095]
Warren Andersen S Trentham-Dietz A Gangnon RE Hampton JM Figueroa JD Skinner HG Engelman CD Klein BE Titus LJ Egan KM Newcomb PA . Reproductive windows, genetic loci, and breast cancer risk. Ann Epidemiol. 2014 May;24(5):376-82
[PubMed ID: 24792587]
Howard KP Klein BE Lee KE Klein R . Measures of body shape and adiposity as related to incidence of age-related eye diseases: observations from the Beaver Dam Eye Study. Invest Ophthalmol Vis Sci. 2014 Apr 21;55(4):2592-8
[PubMed ID: 24667857]
Paulsen AJ Cruickshanks KJ Fischer ME Huang GH Klein BE Klein R Dalton DS . Dry eye in the beaver dam offspring study: prevalence, risk factors, and health-related quality of life. Am J Ophthalmol. 2014 Apr;157(4):799-806
[PubMed ID: 24388838]
Klein R Myers CE Cruickshanks KJ Gangnon RE Danforth LG Sivakumaran TA Iyengar SK Tsai MY Klein BE . Markers of inflammation, oxidative stress, and endothelial dysfunction and the 20-year cumulative incidence of early age-related macular degeneration: the Beaver Dam Eye Study. JAMA Ophthalmol. 2014 Apr 1;132(4):446-55
[PubMed ID: 24481424]
Hanff TC Sharrett AR Mosley TH Shibata D Knopman DS Klein R Klein BE Gottesman RF . Retinal microvascular abnormalities predict progression of brain microvascular disease: an atherosclerosis risk in communities magnetic resonance imaging study. Stroke. 2014 Apr;45(4):1012-7
[PubMed ID: 24549866]
Gangnon RE Lee KE Klein BE Iyengar SK Sivakumaran TA Klein R . Misclassification can explain most apparent regression of age-related macular degeneration: results from multistate models with misclassification. Invest Ophthalmol Vis Sci. 2014 Mar 20;55(3):1780-6
[PubMed ID: 24550369]
Tragante V Barnes MR Ganesh SK Lanktree MB Guo W Franceschini N Smith EN Johnson T Holmes MV Padmanabhan S Karczewski KJ Almoguera B Barnard J Baumert J Chang YP Elbers CC Farrall M Fischer ME Gaunt TR Gho JM Gieger C Goel A Gong Y Isaacs A Kleber ME Mateo Leach I McDonough CW Meijs MF Melander O Nelson CP Nolte IM Pankratz N Price TS Shaffer J Shah S Tomaszewski M van der Most PJ Van Iperen EP Vonk JM Witkowska K Wong CO Zhang L Beitelshees AL Berenson GS Bhatt DL Brown M Burt A Cooper-DeHoff RM Connell JM Cruickshanks KJ Curtis SP Davey-Smith G Delles C Gansevoort RT Guo X Haiqing S Hastie CE Hofker MH Hovingh GK Kim DS Kirkland SA Klein BE Klein R Li YR Maiwald S Newton-Cheh C O'Brien ET Onland-Moret NC Palmas W Parsa A Penninx BW Pettinger M Vasan RS Ranchalis JE M Ridker P Rose LM Sever P Shimbo D Steele L Stolk RP Thorand B Trip MD van Duijn CM Verschuren WM Wijmenga C Wyatt S Young JH Zwinderman AH Bezzina CR Boerwinkle E Casas JP Caulfield MJ Chakravarti A Chasman DI Davidson KW Doevendans PA Dominiczak AF FitzGerald GA Gums JG Fornage M Hakonarson H Halder I Hillege HL Illig T Jarvik GP Johnson JA Kastelein JJ Koenig W Kumari M März W Murray SS O'Connell JR Oldehinkel AJ Pankow JS Rader DJ Redline S Reilly MP Schadt EE Kottke-Marchant K Snieder H Snyder M Stanton AV Tobin MD Uitterlinden AG van der Harst P van der Schouw YT Samani NJ Watkins H Johnson AD Reiner AP Zhu X de Bakker PI Levy D Asselbergs FW Munroe PB Keating BJ . Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci. Am J Hum Genet. 2014 Mar 6;94(3):349-60
[PubMed ID: 24560520]
Klein BE Lee KE Klein R . Statin use and cataracts. JAMA Ophthalmol. 2014 Mar;132(3):366-7
[PubMed ID: 24626837]