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UW Health SMPH
American Family Children's Hospital
John P. Sheehan, MD close
John P. Sheehan, MD

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John P. Sheehan, MD Print Friendly Page

Faculty, University of Wisconsin School of Medicine and Public Health

Dr. Sheehan has extensive expertise in clotting issues, including clotting disorders, thrombotic disorders, hypercoagulable disorders and recurrent venous thromboembolism.


Bleeding Disorders


Pediatric Bleeding Disorders

UW Health Clinics

American Family Children's Hospital
(866) 737-6707 | Map
UW Hospital and Clinics
(866) 737-6707 | (800) 323-8942 | Map
UW Carbone Cancer Center
(608) 265-1700 | (800) 323-8942 | Map

Regional Specialty Clinics

SwedishAmerican Regional Cancer Center (Rockford)
(779) 696-9400 |  Map

Hospital Affiliation(s)

University of Wisconsin Hospital and Clinics (primary)
Veterans Hospital - Wm. S. Middleton Memorial (secondary)

UW School of Medicine and Public Health

Department of Medicine

Professional Certifications and Education

Board Certification Internal Medicine
Fellowship Washington University Medical Center, St. Louis, MO
Residency University of Minnesota Affiliated Hospitals, Minneapolis, MN
Internship University of Minnesota Affiliated Hospitals, Minneapolis, MN
Medical School University of Missouri, Columbia, MO

Medical interpreters are available to help patients communicate with hospital and clinic staff. For more information, please contact interpreter services at (608) 262-9000.


Our doctors provide a wide range of services. The following list represents some, but not all, of the procedures offered by this physician.

Programs & Conditions

PubMed Articles
Misenheimer TM Sheehan JP . The regulation of factor IXa by supersulfated low molecular weight heparin. Biochemistry. 2010 Nov 23;49(46):9997-10005
[PubMed ID: 20945941]
Buyue Y Sheehan JP . Fucosylated chondroitin sulfate inhibits plasma thrombin generation via targeting of the factor IXa heparin-binding exosite. Blood. 2009 Oct 1;114(14):3092-100
[PubMed ID: 19414859]
Buyue Y Whinna HC Sheehan JP . The heparin-binding exosite of factor IXa is a critical regulator of plasma thrombin generation and venous thrombosis. Blood. 2008 Oct 15;112(8):3234-41
[PubMed ID: 18647957]
Misenheimer TM Buyue Y Sheehan JP . The heparin-binding exosite is critical to allosteric activation of factor IXa in the intrinsic tenase complex: the role of arginine 165 and factor X. Biochemistry. 2007 Jul 3;46(26):7886-95
[PubMed ID: 17563121]
Sheehan JP Walke EN . Depolymerized holothurian glycosaminoglycan and heparin inhibit the intrinsic tenase complex by a common antithrombin-independent mechanism. Blood. 2006 May 15;107(10):3876-82
[PubMed ID: 16672689]
Yuan QP Walke EN Sheehan JP . The factor IXa heparin-binding exosite is a cofactor interactive site: mechanism for antithrombin-independent inhibition of intrinsic tenase by heparin. Biochemistry. 2005 Mar 8;44(9):3615-25
[PubMed ID: 15736971]
Sheehan JP Kobbervig CE Kirkpatrick HM . Heparin inhibits the intrinsic tenase complex by interacting with an exosite on factor IXa. Biochemistry. 2003 Sep 30;42(38):11316-25
[PubMed ID: 14503882]