Related | Appendix C. VTE Risk Assessment - Orthopedics - Adult - Inpatient/Ambulatory
Inpatient+Ambulatory
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Venous Thromboembolism Prophylaxis – Adult – Inpatient/Ambulatory
Appendix C. VTE Prophylaxis in Orthopedic Surgery
VTE prophylaxis regimens for orthopedic surgeries
Standard VTE Risk Elevated VTE Risk High Bleed
Risk
Total Hip,
Total Knee,
or Shoulder
Arthroplasty
Apixaban 2.5 mg PO BIDa
ASA 81 mg BID b
ASA 325 mg QD - BID b
Enoxaparin 40 mg SQ dailya
Enoxaparin 30 mg SQ every 12 hrsa
*Fondaparinux 2.5 mg daily b
Rivaroxaban 10 mg PO dailya
Warfarin (target INR 1.8-2.2) b
Apixaban 2.5 mg PO BIDa
Enoxaparin 30 mg SQ every 12 hrsa
Enoxaparin 40 mg SQ dailya
*Fondaparinux 2.5 mg daily b
Rivaroxaban 10 mg PO dailya
Warfarin (target INR 1.8-2.2) b
Mechanical
prophylaxis
Hip Fracture
Surgery
All patients considered at elevated VTE risk:
Apixaban 2.5 mg BID
Enoxaparin 30 mg SQ every 12 hrsa
Enoxaparin 40 mg Sq every 24 hrsa
*Fondaparinux 2.5 mg daily b
Rivaroxaban 10 mg PO dailya
Warfarin (target INR 1.8-2.2) b
Mechanical
prophylaxis
* May be considered for patients with heparin allergy
a: UW Health GRADE Moderate quality evidence, strong recommendation
b: UW Health GRADE Very Low quality evidence, strong recommendation
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